Publications by authors named "Xinjiang Tan"
Article Synopsis
- Sex-biased gene expression varies among human populations, and this study focuses on the Uyghur population in Xinjiang, comparing them to Han Chinese individuals.
- The researchers identified 302 genes and 174 genetic loci that show sex-biased expression, particularly linked to immune functions, with ancestry influencing these differences significantly.
- The findings suggest that the X chromosome interacts with autosomal genes to affect immune-related traits, indicating that genetic background and admixture contribute to sex differentiation in immune responses.
Human genomics is witnessing an ongoing paradigm shift from a single reference sequence to a pangenome form, but populations of Asian ancestry are underrepresented. Here we present data from the first phase of the Chinese Pangenome Consortium, including a collection of 116 high-quality and haplotype-phased de novo assemblies based on 58 core samples representing 36 minority Chinese ethnic groups. With an average 30.
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- The study investigates how specific genetic variations from European and Asian origins influence traits in the Uyghur population.
- Researchers identified nearly 922,000 genetic variants, with a small percentage being associated with gene expression changes relevant to health and disease.
- Key findings suggest that these genetic differences are linked to immunity, metabolism, and diabetes susceptibility, providing new insights into how genetic mixing affects phenotypic variation between Eastern and Western populations.