Prebiotic inulin alleviates anxiety and depression-like behavior in alcohol withdrawal mice by modulating the gut microbiota and 5-HT metabolism.

Background: Alcohol dependence (AD) is a common psychiatric disorder, often accompanied by anxiety and depression. These comorbidities are linked to disturbances in serotonin (5-HT) metabolism and gut microbiota dysbiosis. Clinical studies suggest that inulin, a prebiotic, can alleviate anxiety and depression in AD patients by affecting the gut microbiota, although the mechanisms remain unclear.

Non-uniform failure and differential pressure relief technology of roadway under irregular goafs in deep close-distance coal seams.

In response to the control problems of large-deformation roadways in close-distance coal seams, taking a typical roadway under irregular goafs and residual coal pillar in deep close-distance coal seams as the background, the characteristics of mine pressure and key difficulties in surrounding rock control of roadway are explored and an improvement strategy for controlling surrounding rock is proposed. The stress expression in roadway floor under the influence of residual coal pillar is derived by theoretical calculation. The peak lines of deviatoric stress and vertical stress in roadway after the mining of the upper coal seam are obtained by numerical simulation.