Effects of circPICALM-miR-132-PHKB regulated by METTL3 on proliferation of porcine skeletal muscle satellite cells.

Circular RNA (circRNA) is ubiquitously expressed in highly differentiated eukaryotes, playing an extremely vital regulatory role in muscle growth and development. In this study, we identified circPICALM, a novel circRNA which consists of exons 5 to 9 of the PICALM gene, exhibiting differential expression in the longissimus dorsi muscle (LD) of adult (QA) and newborn (QN) Queshan Black pigs. CircPICALM is resistant to RNase R, mainly located in the cytoplasm with potential coding capacities.

Isocyanic acid-mediated NLRP3 carbamoylation reduces NLRP3-NEK7 interaction and limits inflammasome activation.

Isocyanic acid, as a reactive metabolite synthesized by the enzyme LACC1, can carbamoylate the ε-amino group of lysine residues in proteins. However, the role of isocyanic acid in inflammatory response remains elusive. Herein, we reveal that lipopolysaccharide stimulation increases LACC1-dependent isocyanic acid production, which attenuates inflammation by limiting the NLRP3 inflammasome activation in macrophages primed with lipopolysaccharide for 8 hours.

3D Printed Low-Tortuosity and Ultra-Thick Hierarchical Porous Electrodes for High-Performance Wearable Quasi-Solid-State Zn-VOH Batteries.

Rechargeable aqueous Zn-ion batteries have received considerable attention in energy storage systems owing to their merits of high safety, low cost, and excellent rate performance. However, the unsatisfactory areal energy density and poor cycling performance hinder their practical applications. Herein, the VO·6HO (VOH) nanosheet arrays and Zn nanoflake arrays growing on the 3D-printed reduced graphene oxide/carbon nanotubes (3DP-rGO/CNTs) microlattices employing the electrodeposition technique, and further serve as the cathode and anode for 3D-printed aqueous Zn-VOH battery, respectively.

The Joint Contribution of Host Genetics and Probiotics to Pig Growth Performance.

Intestinal probiotics significantly regulate the growth performance of their host, with their composition being influenced by various factors. While many studies have explored how gut microbiota composition affects growth traits such as body weight and BMI, the research on probiotics influenced by host genetic factors, and their subsequent impact on host growth performance, remains limited. To address this research gap, we collected fecal and tissue samples, as well as phenotypic data, from 193 Yunong black pigs at 280 days of age.

Development of a Feed Conversion Ratio Prediction Model for Yorkshire Boars Using Cumulative Feed Intake.

Feed conversion ratio (FCR) is a key indicator of pig productivity, but its measurement is labor-intensive and time-consuming. This study aimed to construct a predictive model for cumulative feeding intake (CFI), which could help estimate FCR more efficiently and reduce the time and effort needed for measurements. This study included a total of 987 Yorkshire boars raised in specific pathogen-free environments, with feeding and growth data collected using automatic feeders.

Modification of CsAgBiCl Double-Perovskite Photocatalytic Activity by Br Doping.

Developing highly efficient photocatalysts is crucial for photocatalysis technology. Many reports have demonstrated that element doping was an effective strategy for developing highly efficient photocatalysts by broadening the visible light absorption range and suppressing the recombination of photogenerated carriers. Herein, we doped the Br element into CsAgBiCl perovskite to widen the visible light absorption and enhance the charge transfer ability and then developed a highly efficient visible-light photocatalyst based on CsAgBiCl.

Van Der Waals Hybrid Integration of 2D Semimetals for Broadband Photodetection.

Hybrid heterostructures are pivotal in the advanced broadband detection technology. The emergence of 2D semimetals has expanded the range of materials in heterostructures beyond conventional narrow-gap materials for room-temperature broadband detection applications due to their extraordinary optical and electrical properties. This review outlines the cutting-edge and latest advancements in broadband photodetectors (PDs) engineered from heterostructures that synergistically combine 2D semimetals with several different dimensional materials.

Genome-Wide Association Study Pinpoints Novel Candidate Genes Associated with the Gestation Length of the First Parity in French Large White Sows.

Gestation length (GL) is a critical indicator of reproductive performance in sows and is closely associated with other reproductive traits, such as total number born (TNB) and number born alive (NBA). Despite its importance, the genetic mechanisms underlying GL and its impact on reproductive traits remain poorly understood. In this study, we investigated the relationship between GL and reproductive traits using 7013 farrowing records and conducted an imputed whole-genome sequence-based genome-wide association study (GWAS) for GL in first-parity sows, involving 3005 French Large White sows.

Light-Emitting Diodes Based on Metal Halide Perovskite and Perovskite Related Nanocrystals.

Light-emitting diodes (LEDs) based on halide perovskite nanocrystals have attracted extensive attention due to their considerable luminescence efficiency, wide color gamut, high color purity, and facile material synthesis. Since the first demonstration of LEDs based on MAPbBr nanocrystals was reported in 2014, the community has witnessed a rapid development in their performances. In this review, a historical perspective of the development of LEDs based on halide perovskite nanocrystals is provided and then a comprehensive survey of current strategies for high-efficiency lead-based perovskite nanocrystals LEDs, including synthesis optimization, ion doping/alloying, and shell coating is presented.

The cell autonomous and non-autonomous roles of itaconate in immune response.

Itaconate which is discovered as a mammalian metabolite possessing antimicrobial and immunoregulatory activity has attracted much attention in the field of immunometabolism. Itaconate is synthesized by myeloid cells under conditions of pathogen infection and sterile inflammation. In addition to regulating immune response of myeloid cells, itaconate secreted from myeloid cells can also be taken up by non-myeloid cells to exert immunoregulatory effects in a cell non-autonomous manner.

Efficient Orange Light-Emitting Diodes from Nontoxic Organic-Inorganic Hybrid Copper Halides Enabled by Nonionic Surfactant Chemisorption.

Ternary copper halides with an eco-friendly property have emerged as attractive candidates to replace toxic lead-containing perovskites for light-emitting diodes (LEDs), yet achieving long-wavelength electroluminescence remains unexplored. Herein, we report the first realization of orange-emitting LEDs (595 nm) based on nontoxic organic-inorganic PEACuI (PEA = β-phenylethylamine) films enabled by a nonionic surfactant poly(propylene glycol) bis(2-aminopropyl ether) (APPG) chemisorption. Experimental and theoretical analyses rationalize that the APPG additive has strong chemisorption with the Cu-I framework within the grain boundaries of PEACuI films, which not only improves the film's morphology but also passivates the iodine vacancy defects.

Advances in multi-omics integrated analysis methods based on the gut microbiome and their applications.

The gut microbiota actually shares the host's physical space and affects the host's physiological functions and health indicators through a complex network of interactions with the host. However, its role as a determinant of host health and disease is often underestimated. With the emergence of new technologies including next-generation sequencing (NGS) and advanced techniques such as microbial community sequencing, people have begun to explore the interaction mechanisms between microorganisms and hosts at various omics levels such as genomics, transcriptomics, metabolomics, and proteomics.

Genomic prediction accounting for dominance and epistatic genetic effects on litter size traits in Large White pigs.

Litter size traits of sows are crucial for the economic benefits of the pig industry. Three phenotypic traits of 1,206 Large White pigs, the total number born (TNB), number born alive (NBA), and number of healthy piglets (NHP), were recorded. We evaluated a series of genomic best linear unbiased prediction models that sequentially added additive effects (model A), dominance effects (model A + D), and epistatic effects (model A + D + AA, model A + D + AA + AD, and model A + D + AA + AD + DD) using chip data and imputed whole-genome sequencing (WGS) data to estimate genetic parameters and predictive accuracy.

Prognostic Impact of Adjuvant Immunotherapy in Patients With Resectable NSCLC After Neoadjuvant Chemoimmunotherapy: A Brief Report.

Objective: The potential survival benefits of adjuvant immunotherapy for resectable NSCLC after neoadjuvant chemoimmunotherapy, and the optimal number of adjuvant immunotherapy cycles, remain uncertain. This study aims to evaluate the prognostic impact of adjuvant immunotherapy and determine the optimal number of cycles.

Methods: A total of 438 patients who received neoadjuvant chemoimmunotherapy between August 2019 and June 2022 across four hospitals were enrolled in this study, with a median follow-up time of 31.

Single-step genome-wide association study reveals candidate genes for body mass index trait in Yunong-black pigs.

Body mass index (BMI) can serve as a reasonable indicator of overall body fat content in pigs. This study aimed to identify underlying variants and candidate genes associated with BMI in Yunong-black pigs. A single-step genome-wide association analysis (GWAS) was performed on 1405 BMI records and 924 Yunong-black pigs genotyped using a 50 K SNP Chip.

Simultaneous achieving negative photoconductivity response and volatile resistive switching in CsCoCl single crystals towards artificial optoelectronic synapse.

The development of negative photoconductivity (NPC)-related devices is of great significance for numerous applications, such as optoelectronic detection, neuromorphic computing, and optoelectronic synapses. Here, an unusual but interesting NPC phenomenon in the novel cesium cobalt chlorine (CsCoCl) single crystal-based optoelectronic devices is reported, which simultaneously possess volatile resistive switching (RS) memory behavior. Joint experiment-theory characterizations reveal that the NPC behavior is derived from the intrinsic vacancy defects of CsCoCl, which could trap photogenerated charge carriers and produce an internal electric field opposite to the applied electric field.

Differential Impacts of Invasive Percutaneous Coronary Intervention and Conservative Strategy on Elderly Patients with Non-ST-Segment Elevation Myocardial Infarction: An Analysis of Short-Term and Long-Term Survival.

The present study investigated the short-term and long-term outcomes of an invasive strategy in percutaneous coronary intervention (PCI) and a conservative strategy in non-ST-segment elevation myocardial infarction (NSTEMI) patients older than 80 years, with the aim to identify the strategy that is more beneficial than the other to this demographic population. A total of 139 patients from Beijing Anzhen Hospital and the Cao County People's Hospital were included in this study, comprising those aged >80 years and diagnosed with NSTEMI between 2017 and 2022. The main observation indicator was all-cause death, whereas the secondary indicators included composite endpoint events of recurrent myocardial infarction, need for urgent revascularization, recurrent angina, stroke, death, and major bleeding.

A targeted proteomics screen reveals serum and synovial fluid proteomic signature in patients with gout.

Objective: To characterize the inflammatory proteome in both serum and synovial fluid (SF) of patients with gout, in comparison to healthy controls and individuals with osteoarthritis (OA), by utilizing a high-quality, high-throughput proteomic analysis technique.

Methods: Using the Olink Target 48 Inflammation panel, we measured serum concentrations of 45 inflammatory proteins in gout, OA, and healthy controls. We analyzed protein levels in SF samples from gout and OA, performed ROC curve analyses to identify diagnostic biomarkers, evaluate efficacy, and set cut-off values.

Effects of root-irrigation with metalaxyl-M and hymexazol on soil physical and chemical properties, enzyme activity, and the fungal diversity, community structure and function.

Fungicides are commonly applied through root irrigation in tobacco fields to control soil-borne diseases, and they affect soil microorganisms. However, the effects of metalaxyl-M and hymexazol, used to manage tobacco black shank disease, on these soil microecology remain poorly understood. This study employed high-throughput sequencing technology to explore the soil physical and chemical properties, soil enzyme activity, and the diversity, community structure and function of soil fungi in tobacco fields following root irrigation with metalaxyl-M and hymexazol.

Stable Long-Persistent Luminescence from Self-Activated CaSbO Induced by Intrinsic Defects.

Long-persistent luminescence (LPL) materials have attracted intensive attention due to their fascinating emission after excitation. However, current LPL materials typically depend on external doping to introduce traps or emitting centers, resulting in a complex synthesis and controllability. For the first time, we develop another category of undoped LPL materials based on antimonate CaSbO, which exhibits blue LPL for over 8000 s.

The neutrophil-lymphocyte ratio is associated with all-cause and cardiovascular mortality in cardiovascular patients.

This study investigates the relationship of neutrophil-lymphocyte ratio (NLR) with the risk of all-cause and cardiovascular mortality in patients with cardiovascular disease. The data for this analysis came from 2239 participants with cardiovascular disease of the National Health and Nutrition Examination Survey conducted between 1999-2018. The optimal cutoff point for NLR was determined using maximally selected rank statistics.

Delayed diagnosis of angioimmunoblast T-cell lymphoma presenting with immunoglobulin a vasculitis.

Although vasculitis and renal involvement might be associated with malignancy, they are rarely associated with lymphoproliferative diseases. We observed a case of immunoglobulin A vasculitis associated with segmental and focal glomerulonephritis in a patient with Angioimmunoblastic T-cell lymphoma. The most interesting aspect of this case is that this patient's main initial manifestations were skin rash and fever.

Colloidal Synthesis of Blue-Emitting CsTmCl Nanocrystals via Localized Excitonic Recombination for Down-Conversion White Light-Emitting Diodes.

Lead-halide perovskite nanocrystals (NCs) have gained significant attention for their promising applications in lighting and display technologies. However, blue-emitting NCs have struggled to match the high efficiency of their red and green counterparts. Moreover, many reported blue-emitting perovskite NCs contain heavy metal lead (Pb), which poses risks to human health and the environment.

Differential chromatin accessibility and Gene Expression Associated with Backfat Deposition in pigs.

Background: Backfat serves as a vital fat reservoir in pigs, and its excessive accumulation will adversely impact pig growth performance, farming efficiency, and pork quality. The aim of this research is to integrate assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) and RNA sequencing (RNA-seq) to explore the molecular mechanisms underlying porcine backfat deposition.

Results: ATAC-seq analysis identified 568 genes originating from 698 regions exhibiting differential accessibility, which were significantly enriched in pathways pertinent to adipocyte differentiation and lipid metabolism.