Regulation of endocrine cell alternative splicing revealed by single-cell RNA sequencing in type 2 diabetes pathogenesis.

The prevalent RNA alternative splicing (AS) contributes to molecular diversity, which has been demonstrated in cellular function regulation and disease pathogenesis. However, the contribution of AS in pancreatic islets during diabetes progression remains unclear. Here, we reanalyze the full-length single-cell RNA sequencing data from the deposited database to investigate AS regulation across human pancreatic endocrine cell types in non-diabetic (ND) and type 2 diabetic (T2D) individuals.

Evaluation of Hypoglycemic Activity and Sub-Acute Toxicity of the Novel Biochanin A-Chromium(III) Complex.

The novel biochanin A-chromium(III) complex was synthesized by chelating chromium with biochanin A (BCA). The structure of the complex was determined and the complex ([CrBCA]) was composed of chromium(III) and three ligands, and the chromium content was 55 μg/mg. The hypoglycemic activity of the complex was studied in db/db mice and C57 mice.

N-(9H-Fluoren-9-yl-idene)-4-methyl-aniline.

In the title compound, C(20)H(15)N, the fluorene unit is essentially planar [r.m.s.

Chlorido[(E)-2-hydr-oxy-6-(isonicotinoyl-hydrazonometh-yl)phen-yl]mercury(II) monohydrate.

The asymmetric unit of the title compound, [Hg(C(13)H(10)N(3)O(2))Cl]·H(2)O, contains two independent mercury(II) complexes with slightly different conformations, related via a pseudo-inversion centre, and two water mol-ecules. The Hg(II) atoms show a typical linear geometry to a C atom of the benzene ring and to a Cl atom. A benzene C and the azomethine N atom chelate the Hg(II) atoms with weak intra-molecular Hg⋯N bonding distances of 2.