Publications by authors named "Xinhao Jia"
Article Synopsis
- Transmissible gastroenteritis virus (TGEV) is a harmful coronavirus that can lead to deadly intestinal diseases in young pigs, particularly those under two weeks old, with a lethal outcome rate of 100%.
- The research utilized monocyte-derived porcine dendritic cells (DCs) to examine how TGEV interacts with these important immune cells, revealing that TGEV can replicate in these cells while UV-inactivated TGEV cannot.
- Findings showed that TGEV infection significantly raised the expression of SLA-DR, a crucial molecule for immune response, and that the ORF3b protein of TGEV enhances this expression at a transcriptional level, shedding light on the virus's pathogenic mechanisms.
Porcine deltacoronavirus (PDCoV) is a global epidemic enteropathogenic coronavirus that mainly infects piglets, and causes huge losses to the pig industry. However, there are still no commercial vaccines available for PDCoV prevention and controlment. Receptor-binding domain (RBD) is located at the S1 subunit of PDCoV and is the major target for developing viral inhibitor and vaccine.
View Article and Find Full Text PDFPorcine deltacoronavirus (PDCoV) is a novel coronavirus that causes diarrhea in pigs of various ages, especially in suckling piglets, and there are no effective measures to prevent and control PDCoV currently. In this study, two adjuvants Al(OH) and ODN2395 working through different mechanisms were used to prepare inactivated PDCoV vaccines, and the immune effects of PDCoV inactivated vaccines were assessed in mice. From the results, we found that both PDCoV/Al(OH) vaccine and PDCoV/2395 vaccine could induce IgG and neutralizing antibodies with high levels in mice.
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