Publications by authors named "Xinhao Hou"

Article Synopsis
  • The pairing center (PC) in C. elegans chromosomes is vital for homolog pairing and synapsis, with specific DNA motifs that recruit certain meiosis proteins (ZIM-1, ZIM-2, ZIM-3, HIM-8).
  • Researchers have determined the crystal structures of the DNA binding domains of HIM-8, ZIM-1, and ZIM-2 bound to their respective PC DNA motifs, revealing important details about how they interact.
  • The study highlights that specific DNA-contacting residues are concentrated in the ZF1-2 domains and that the CTD may enhance the flexibility and specificity of binding to different PC DNA motifs, indicating a co-evolution of these elements.
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Domain adaptation techniques are crucial for addressing the discrepancies between training and testing data distributions caused by varying operational conditions in practical bearing fault diagnosis. However, transfer fault diagnosis faces significant challenges under complex conditions with dispersed data and distinct distribution differences. Hence, this paper proposes CWT-SimAM-DAMS, a domain adaptation method for bearing fault diagnosis based on SimAM and an adaptive weighting strategy.

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Based on the analysis of data from listed enterprises in China between 2011 and 2022, we investigate the influence of digital transformation on the governance efficiency for minority shareholders. The results show that the extent of digital transformation exert a negative effect on the agency costs incurred from related-party transactions. The mechanism examination elucidates that digital transformation augments the governance efficiency for minority shareholders by boosting attendance at shareholders' meetings and enhancing the exit threat for minority shareholders.

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The chromatin organization modifier domain (chromodomain) is an evolutionally conserved motif across eukaryotic species. The chromodomain mainly functions as a histone methyl-lysine reader to modulate gene expression, chromatin spatial conformation and genome stability. Mutations or aberrant expression of chromodomain proteins can result in cancer and other human diseases.

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Histone methylation plays crucial roles in the development, gene regulation, and maintenance of stem cell pluripotency in mammals. Recent work shows that histone methylation is associated with aging, yet the underlying mechanism remains unclear. In this work, we identified a class of putative histone 3 lysine 9 mono/dimethyltransferase genes ( and ), mutations in which induce synergistic lifespan extension in the long-lived DAF-2 (insulin growth factor 1 [IGF-1] receptor) mutant in .

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Dietary restriction usually suppresses biosynthesis but activates catabolic pathways in animals. However, the short-term starvation enhances biosynthetic activities and promotes ribosomal biogenesis in adult Caenorhabditis elegans. The mechanism underlying the processes remains largely unknown.

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Ribosome biogenesis is a multistep process, during which mistakes can occur at any step of pre-rRNA processing, modification, and ribosome assembly. Misprocessed rRNAs are usually detected and degraded by surveillance machineries. Recently, we identified a class of antisense ribosomal siRNAs (risiRNAs) that down-regulate pre-rRNAs through the nuclear RNAi pathway.

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