Intestinal metabolite xylulose inhibits colorectal cancer by inducing apoptosis through the MAPK signalling pathway.

Background: The intestinal metabolites are involved in the initiation, progression and metastasis of colorectal cancer (CRC). They are a potential source of agents for cancer therapy. Our previous study identified altered faecal metabolites between CRC patients and healthy volunteers.

Norepinephrine may promote the progression of related colorectal cancer via quorum sensing signalling.

is closely correlated with tumorigenesis in colorectal cancer (CRC). We aimed to investigate the effects of host norepinephrine on the carcinogenicity of in CRC and reveal the underlying mechanism. The results revealed that both norepinephrine and bacterial quorum sensing (QS) molecule auto-inducer-2 (AI-2) were positively associated with the progression of related CRC ( < 0.

Gut microbiota-derived autoinducer-2 regulates lung inflammation through the gut-lung axis.

Objective: This study aimed to determine whether autoinducer-2 (AI-2), a crucial bacterial metabolite and quorum sensing molecule, is involved in lung immunity through the gut-lung axis.

Methods: The level of AI-2 and the gut microbiome composition were analysed in the stools from pneumonic patients and the mouse model of acute lung injury. The effect of AI-2 on lung inflammation was further investigated in the mouse model.

Improvement on stability of direct modulation laser with integrated active feedback by partial corrugated gratings.

Researchers have developed a uniform grating DFB with an integrated active optical feedback waveguide (UG-AFDFB) to enhance the modulation speed of direct modulation lasers (DMLs) while reducing costs based on identical active layer designations. However, this design has difficulties in obtaining high single mode yield (SMY) and low relative intensity noise (RIN) as a result of the strong optical feedback caused by the integrated active feedback waveguide (AFW) and the random phase of the facet phase. In this paper, a partial corrugated grating DFB with an integrated active optical feedback waveguide (PG-AFDFB) is proposed to address this issue.

A 1,8-naphthimide-based Fluorescent Probe for Analyzing DMF/HO Composition.

A novel 1,8-naphthalimide fluorescent probe (BNAS) containing 2-thiopheneethylamine moiety was designed and synthesized for analyzing the composition of N,N-dimethylformamide (DMF)/deionized water (HO) mixtures. With the increase of DMF content, the fluorescence of the system was enhanced from dark to bright yellow-green. Taking 15% (volume) DMF content as the dividing point, the fluorescence intensity of the system at 535 nm showed two good linear relationships with the DMF content 1-15% and 15-99%, based on which the composition of the DMF/HO mixtures with a volume ratio of 1/99-99/1 could be quickly and efficiently analyzed with high selectivity and sensitivity.

Alterations of the Gut Microbiome and Fecal Metabolome in Colorectal Cancer: Implication of Intestinal Metabolism for Tumorigenesis.

The gut microbiota and its metabolites are important for host physiological homeostasis, while dysbiosis is related to diseases including the development of cancers such as colorectal cancer (CRC). In this study, we characterized the relationship of an altered gut microbiome with the fecal metabolome in CRC patients in comparison with volunteers having a normal colorectal mucous membrane (NC). The richness and composition of the microbiota in fecal samples of 30 CRC patients and 36 NC controls were analyzed through 16S rRNA gene sequencing, and the metabolome was determined by ultra-performance liquid chromatography coupled to tandem mass spectrometry.

Low Abundance of in Human Colorectal Cancer Is Associated with Decreased Natural Killer Cells.

A limited number of studies have demonstrated the role of () in human colorectal cancers (CRCs). The association of abundance with the density of natural killer (NK) cells has not been investigated before. In this study, the abundance in 60 CRC specimens, 20 adenoma (AD) specimens, and 29 normal colorectal tissues (NCs) specimens was investigated using the fluorescence in situ hybridization of 16S ribosomal RNA.