Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding.

Glioblastoma is a highly aggressive primary brain tumor with glioblastoma stem cells (GSCs) enforcing the intra-tumoral hierarchy. Plasma cells (PCs) are critical effectors of the B-lineage immune system, but their roles in glioblastoma remain largely unexplored. Here, we leverage single-cell RNA and B cell receptor sequencing of tumor-infiltrating B-lineage cells and reveal that PCs are aberrantly enriched in the glioblastoma-infiltrating B-lineage population, experience low level of somatic hypermutation, and are associated with poor prognosis.

A comparative cohort study of post-COVID-19 conditions based on physical examination records in China.

Background: Coronavirus disease-2019 (COVID-19), caused by SARS-CoV-2 virus infection, is characterized as a multisystem disease, potentially yielding multifaceted consequences on various organs at multiple levels. At the end of 2022, over 90% of the Chinese population was infected by SARS-CoV-2 within 35 days because of adjustments to epidemic prevention and control policies. This short-term change provides an unprecedented opportunity for comparative studies on COVID-19 infection among large populations.

OPMS - A web-based ocean pollution monitoring system.

Marine pollution poses significant risks to both marine ecosystems and human health, requiring effective monitoring and control measures. This study presents the Ocean Pollution Monitoring System (OPMS), a web application designed to visualize the seasonal and annual fluctuations of marine pollutants along coastal regions in Canada. The pollutants include fecal coliform and biotoxins such as paralytic shellfish poisoning (PSP), and amnesic shellfish poisoning (ASP).

Ubiquitination of OsCSN5 by OsPUB45 activates immunity by modulating the OsCUL3a-OsNPR1 module.

The COP9 signalosome (CSN) is a highly conserved protein complex in eukaryotes, with CSN5 serving as its critical catalytic subunit. However, the role of CSN5 in plant immunity is largely unexplored. Here, we found that suppression of in rice enhances resistance against the fungal pathogen and the bacterial pathogen pv.

Treating myocardial infarction via a nano-ultrasonic contrast agent-mediated high-efficiency drug delivery system targeting macrophages.

Following myocardial infarction (MI), the accumulation of CD86-positive macrophages in the ischemic injury zone leads to secondary myocardial damage. Precise pharmacological intervention targeting this process remains challenging. This study engineered a nanotherapeutic delivery system with CD86-positive macrophage-specific targeting and ultrasound-responsive release capabilities.

R(3780) Resonance Interpreted as the 1^{3}D_{1}-Wave Dominant State of Charmonium from Precise Measurements of the Cross Section of e^{+}e^{-}→Hadrons.

We report the precise measurements of the cross section of e^{+}e^{-}→hadrons at center-of-mass energies from 3.645 to 3.871 GeV.

A transformer-based deep learning survival prediction model and an explainable XGBoost anti-PD-1/PD-L1 outcome prediction model based on the cGAS-STING-centered pathways in hepatocellular carcinoma.

Recent studies suggest cGAS-STING pathway may play a crucial role in the genesis and development of hepatocellular carcinoma (HCC), closely associated with classical pathways and tumor immunity. We aimed to develop models predicting survival and anti-PD-1/PD-L1 outcomes centered on the cGAS-STING pathway in HCC. We identified classical pathways highly correlated with cGAS-STING pathway and constructed transformer survival model preserving raw structure of pathways.

Dysregulation of ubiquitination modification in renal cell carcinoma.

Renal cell carcinoma (RCC) is a malignant tumor of the renal tubular epithelial cells with a relatively high incidence rate worldwide. A large number of studies have indicated that dysregulation of the ubiquitination, including ubiquitination and dysregulation, is associated with the occurrence and development of RCC. This review focuses on several abnormal signaling pathways caused by E3 ligases and deubiquitinases.

Nanomembrane on Graphene: Delamination Dynamics and 3D Construction.

Freestanding nanomembranes fabricated by lift-off technology have been widely utilized in microelectromechanical systems, soft electronics, and microrobotics. However, a conventional chemical etching strategy to eliminate nanomembrane adhesion often restricts material choice and compromises quality. Herein, we propose a nanomembrane-on-graphene strategy that leverages the weak van der Waals adhesion on graphene to achieve scalable and controllable release and 3D construction of nanomembranes.

Designing Carbon-Foam Composites via Molten-State Reduction for Multifunctional Electromagnetic Interference Shielding.

Advanced electromagnetic interference (EMI) shielding materials are in great demand because of the severe electromagnetic population problem caused by the explosive growth of advanced electronics. Besides superior EMI shielding properties, the mechanical strength of the shielding materials is also critical for some specific application scenarios (e.g.

A comparative analysis of lumboperitoneal shunt outcomes in patients with post-hemorrhagic and post-traumatic hydrocephalus.

Hydrocephalus, whether arising from post-hemorrhagic or post-traumatic origins, poses significant challenges in clinical management. Lumboperitoneal shunting (LPS) emerges as a viable therapeutic intervention, yet comparative analyses between these etiologies remain scarce. This retrospective study aims to compare the efficacy and safety of LPS placement in patients with post-hemorrhagic (PHH) and post-traumatic hydrocephalus (PTH).

Self-assembled hole-selective contact for efficient Sn-Pb perovskite solar cells and all-perovskite tandems.

Self-assembled monolayers (SAMs) have displayed unpredictable potential in efficient perovskite solar cells (PSCs). Yet most of SAMs are largely suitable for pure Pb-based devices, precisely developing promising hole-selective contacts (HSCs) for Sn-based PSCs and exploring the underlying general mechanism are fundamentally desired. Here, based on the prototypical donor-acceptor SAM MPA-BT-BA (BT), oligoether side chains with different length (i.

A filter inspired by deep-sea glass sponges for oil cleanup under turbulent flow.

Oil spill disasters lead to widespread and long-lasting social, economical, environmental and ecological impacts. Technical challenges remain for conventional static adsorption due to hydrodynamic instability under complex water-flow conditions, which results in low oil-capture efficiency, time delay and oil escape. To address this issue, we design a vortex-anchored filter inspired by the anatomy of deep-sea glass sponges (E.

Gigantic Tellegen responses in metamaterials.

Tellegen medium has long been a topic of debate, with its existence being contested over several decades. It was first proposed by Tellegen in 1948 and is characterized by a real-valued cross coupling between electric and magnetic responses, distinguishing it from the well-known chiral medium that has imaginary coupling coefficients. Significantly, Tellegen responses are closely linked to axion dynamics, an extensively studied subject in condensed matter physics.

Neuronal guidance factor Sema3A inhibits neurite ingrowth and prevents chondrocyte hypertrophy in the degeneration of knee cartilage in mice, monkeys and humans.

Osteoarthritis (OA) is a degenerative joint disease accompanied with the loss of cartilage and consequent nociceptive symptoms. Normal articular cartilage maintains at aneural state. Neuron guidance factor Semaphorin 3A (Sema3A) is a membrane-associated secreted protein with chemorepulsive properties for axons.

Efficient and Stable Extraction of Nano-Sized Plastic Particles Enabled by Bio-inspired Magnetic "Robots" in Water.

In this research, a rationally-designed strategy was employed to address the crucial issue of removing nano-plastics (NPs) from aquatic environments, which was based on fabricating sea urchin-like structures of FeO magnetic robots (MagRobots). Through imitating the sea urchin's telescopic tube foot movement and predation mechanism, the unique structures of the MagRobots were designed to adapt to the size and surface interactions of NPs, leading to a high efficiency of NPs removal (99%), as evidenced by the superior performance of 594.3 mg/g for the removal of polystyrene (PS) nanoparticles from water, with 3300% increase over magnetic FeO without structural design.

Circulatory age-associated B cells: Their distinct transcriptomic characteristics and clinical significance in drug-naïve patients with rheumatoid arthritis.

Age-associated B cells (ABCs) have been implicated in the pathogenesis of autoimmune diseases. However, the global gene expression and clinical significance of circulatory ABCs in rheumatoid arthritis (RA) remain poorly understood. Here, single-cell RNA sequencing identified nine B cell subsets in peripheral blood of RA patients, including ABCs.

Rise in Minimally Invasive Surgery for Colorectal Cancer Is Associated With Adoption of Robotic Surgery.

Background: Minimally invasive surgery is associated with improved short-term outcomes and similar long-term oncologic outcomes for colorectal cancer patients compared with open surgery. Although the robotic approach has ergonomic and technical benefits, how it has impacted utilization of traditional laparoscopic surgery and minimally invasive surgery overall is unclear.

Objective: Describe trends in open, robotic, and laparoscopic approaches for colorectal cancer resections and examine factors associated with minimally invasive surgery.

Intracellular metal ion-based chemistry for programmed cell death.

Intracellular metal ions play essential roles in multiple physiological processes, including catalytic action, diverse cellular processes, intracellular signaling, and electron transfer. It is crucial to maintain intracellular metal ion homeostasis which is achieved by the subtle balance of storage and release of metal ions intracellularly along with the influx and efflux of metal ions at the interface of the cell membrane. Dysregulation of intracellular metal ions has been identified as a key mechanism in triggering programmed cell death (PCD).

18F-5-fluoro-aminosuberic acid PET/CT imaging of oxidative-stress features during the formation of DEN-induced rat hepatocellular carcinoma.

The role of oxidative stress metabolism during hepatocellular carcinoma (HCC) formation potentially allows for positron emission tomography (PET) imaging of oxidative stress activity for early and precise HCC detection. However, there is currently limited data available on oxidative-stress-related PET imaging for longitudinal monitoring of the pathophysiological changes during HCC formation. This work aimed to explore PET-based longitudinal monitoring of oxidative stress metabolism and determine the sensitivity of [18F]-5-fluoroaminosuberic acid ([18F]FASu) for assessing pathophysiological processes in diethylnitrosamine (DEN) induced rat HCC.

First Report of Root Rot in Caused by in China.

Aralia elata (Miq.) Seem, is an important cash crop in northeastern China. The tender shoots are rich in amino acids, vitamins, and trace elements, and the saponins of leaves and roots have antioxidant and immune-boosting properties.

[Immuno Phenotypic Characteristics of Bone Marrow Monocytes and Its Clinical Significance in Patients with Multiple Myeloma].

Objective: To explore the characteristics of the immunophenotypic expression of bone marrow monocytes (M) and its clinical significance in patients with multiple myeloma (MM).

Methods: The monocyte immunophenotypes expression of 67 MM and 30 anemic patients (control group) were detected by flow cytometry. The immunophenotypes that exhibited statistical differences from the control group were screened out.