Publications by authors named "Xingyuan Ye"
A KCO-promoted tandem ring-opening/ring-closing of -alkynyl-2-oxazolidinones has been described, affording 2-oxazolines in 42-99% yields without column chromatography isolation. This operationally simple reaction proceeds under ambient conditions without a transition-metal catalyst and an external oxidant and can be applied for the late-stage functionalization of biologically active compounds.
View Article and Find Full Text PDFPhI(OAc)-mediated trifluoromethylthiolation/oxidative cyclization of ynamides.
Org Biomol Chem
October 2021
Article Synopsis
- Researchers developed a method using PhI(OAc) to perform trifluoromethylthiolation and oxidative cyclization on ynamides, leading to the creation of CFS-substituted oxazolidine-2,4-diones.
- This process offers an efficient way to obtain compounds that contain a quaternary carbon center, achieving yields between 38% and 85%.
- The method also demonstrates high chemoselectivity, with a ratio of up to 99:1 in favor of the desired product.