Combination of adenosine blockade and ferroptosis for photo-immunotherapy of triple negative breast cancer with aptamer-modified copper sulfide.

Combination of immunotherapy and photothermal therapy (PTT) provides a promising therapeutic performance for tumors. However, it still faces negative feedback from suppressive factors such as adenosine. Herein, we developed a new nanodrug that can combine adenosine blockade and ferroptosis to promote the photoimmunotherapy of triple negative breast cancer (TNBC).

Combined effect of healthy lifestyles and obesity on cardiometabolic risks in Chinese rural adults.

Background: Combined effect of healthy lifestyles and obesity on cardiometabolic risks were unclear in Chinese rural adults. We aimed to assess the above-mentioned issue.

Methods: This study included 25,123 adults from baseline survey of Henan rural cohort study.

Identification of MORF4L1 as an endogenous substrate of CRBN and its potential role as a therapeutic target in cancer.

The ubiquitin-proteasome system (UPS) is essential for cellular homeostasis, regulating the degradation of proteins involved in key processes such as cell cycle, apoptosis, and DNA repair. Dysregulation of the UPS is implicated in hepatocellular carcinoma (HCC), contributing to tumor progression and therapeutic resistance. The cereblon (CRBN) E3 ubiquitin ligase complex is a crucial component of the UPS, particularly in modulating protein degradation in response to small-molecule modulators like thalidomide.

Dipicolylamine Derivatives Bearing Pyrene and Anthracene as Molecular Probes for Cu and HS.

Two dipicolylamine (DPA) derivatives with the pyrene and anthracene groups, 1-(pyren-1-yl)-N, N-bis-(pyridine-2-ylmethyl)benzylamine (L1) and 1-(anthracen-9-yl)-N, N-bis-(pyridine-2-ylmethyl)benzylamine (L2) were synthesized, characterized, and their affinitive properties for metal ions were studied. The mass spectroscopy and Job's plots showed that L1 and L2 reacted with Cu and formed complexes [Cu(L1)(solvent)] (L1-Cu) and [Cu(L2)(solvent)] (L2-Cu), respectively. Both L1 and L2 were fluorescent probes recognizing Cu via the emission quenching and further detecting HS via the emission revival.

Survival benefit associated with liver transplantation for hepatocellular carcinoma based on tumor burden scores at listing.

Introduction: Liver transplantation (LT) provides significant survival benefits to patients with unresectable HCC. In the United States, organ allocation policies for HCCs within the United Network for Organ Sharing criteria do not prioritize patients based on their differences in oncological characteristics. This study assessed whether transplant-associated survival benefits (TASBs) vary among patients with different tumor burden scores (TBS) measured at the time of listing.

Effect of Laser Quenching on Wire-Powder Collaborative Arc Additive Manufacturing of Ti6Al4V-Cu Alloys with 2.4% and 7.9% Copper Content.

In this work, Ti6Al4V-Cu alloys with different Cu contents (2.4 and 7.9 wt.

The GD-1 Stellar Stream Perturber as a Core-collapsed Self-interacting Dark Matter Halo.

The GD-1 stellar stream exhibits spur and gap structures that may result from a close encounter with a dense substructure. When interpreted as a dark matter subhalo, the perturber is denser than predicted in the standard cold dark matter (CDM) model. In self-interacting dark matter (SIDM), however, a halo could evolve into a phase of gravothermal collapse, resulting in a higher central density than its CDM counterpart.

Roles of waste iron scraps in anammox system treating sulfide-containing wastewater: Alleviating sulfide inhibition, promoting novel anammox bacteria enrichment, and enhancing nitrogen removal capacity.

In this study, waste iron scraps (WIS) were exerted to alleviate sulfide inhibition on anammox bacteria and promote anammox nitrogen removal from sulfide-containing wastewater.Short-term batch experiments showed that WIS-addition led to the anammox bacteria activity increasing by 124.8 % at an initial sulfide concentration of 40 mgS/L.

Impact of kidney allocation system 250 policy on 1-year graft loss.

A new deceased donor kidney allocation system (KAS250) was implemented in March 2021 that prioritizes recipients within a 250-nautical mile radius of the donor hospital. KAS250 was implemented to reduce geographic disparities in access to kidney transplantation. Studies have shown an increase in cold ischemia time (CIT) after KAS250 implementation but the impact on graft outcomes is unknown.

Non-Flammable fluorinated gel polymer electrolyte for safe lithium metal batteries in harsh environments.

Compared to liquid electrolytes, gel polymer electrolytes (GPEs) offer enhanced safety and represent an up-and-coming option for high-energy-density lithium metal batteries (LMBs). However, several challenges hindered the practical application of GPEs for LMBs, such as low ionic conductivity at room temperature, decomposition at high voltage, and poor interfacial compatibility with lithium anode. In this study, a non-flammable fluorinated GPE was synthesized using 2,2,2-trifluoroethyl acrylate (TFEA) and ethoxylated trimethylolpropane triacrylate (ETPTA) as precursor materials, with succinonitrile (SN) incorporated as a plasticizer and a dual-salt system of lithium bis(trifluoro-methane) sulfonimide and lithium difluoroxalate borate.

Microglia Process α-Synuclein Fibrils and Enhance their Pathogenicity in a TREM2-Dependent Manner.

Parkinson's disease (PD) is characterized by the deposition of misfolded α-synuclein (α-syn) in the brain. Converging evidence indicates that the intracellular transmission and subsequent templated amplification of α-syn are involved in the onset and progression of PD. However, the molecular mechanisms underlying the cell-to-cell transmission of pathological α-syn remain poorly understood.

Sugary beverages intake and risk of chronic kidney disease: the mediating role of metabolic syndrome.

Background: Although several studies linked the sugary beverages to chronic kidney disease (CKD), the role of different types of sugary beverages in the development of CKD remained inconsistent. This study aimed to examine the associations of sugar-sweetened beverages (SSBs), artificially-sweetened beverages (ASBs), and natural juices (NJs) with CKD risk, and assess the extent to which the associations were mediated through metabolic syndrome (MetS).

Methods: This is a prospective analysis of 191,956 participants from the UK Biobank.

Case Report and Literature Review of "Treatment Failure" of Aspergillus Infection Secondary to Influenza a Virus.

Purpose: Increased clinical manifestations combined with increased lung imaging findings during antifungal therapy are often misjudged as failure of antifungal therapy, and should be vigilant against immune reconstitution inflammatory syndrome.

Case: We describes a case of invasive pulmonary Aspergillus infection after Influenza A Virus (IAV). After active antifungal therapy, the patient's clinical symptoms continued to worsen, imaging lesions continued to progress, laboratory indicators improved, and immune reconstitution inflammatory syndrome was considered.

Mitigating High-risk EBV and CMV Through Kidney Paired Donation: A Survey of Potential Donor and Recipient Candidates.

Background: High-risk cytomegalovirus (CMV) and Epstein-Barr virus (EBV) mismatches (ie, seropositive donors to seronegative recipients) among kidney transplant recipients lead to increased healthcare utilization, inferior allograft outcomes, and high mortality. We assessed the interest among prospective kidney donor and recipient candidates to participate in kidney paired donation (KPD) for averting CMV/EBV high-risk mismatches.

Methods: We surveyed 51 potential living donors and 102 kidney recipient candidates presenting for their evaluation visit at the University of Pittsburgh Medical Center between October 2022 and May 2023.

Detection of a Planar Tetracoordinate Hydrogen within the Indium Framework by Quantum Dynamics Theory.

In this work, we consider the question how to detect the planar tetracoordination hydrogen geometry which was recently proposed by electronic structure calculations on the InH system ( , , e202317312; e202400927; e202403214). Keeping the symmetry, a two-dimensional model of InH is designed to build the nonadiabatic Hamiltonian operator with the lowest-lying singlet and triplet states coupled with spin-orbit coupling. The electronic energies in fitting the potential energy matrix are computed at either the MRCI or CCSD (T) level.

Dendritic cell mineralocorticoid receptor controls blood pressure by regulating T helper 17 differentiation: role of the Plcβ1/4-Stat5-NF-κB pathway.

Background And Aims: Dendritic cells (DCs) are closely related to blood pressure (BP) regulation. Mineralocorticoid receptor (MR) is an important drug target for antihypertensive treatment. However, the role of DC MR in the pathogenesis of hypertension has not been fully elucidated.

Microglia-derived Galectin-9 drives amyloid-β pathology in Alzheimer's disease.

The accumulation of amyloid-β (Aβ) and overactivation of microglia contribute to the pathogenesis of Alzheimer's disease (AD), but the interaction between microglial activation and Aβ deposition in AD remains elusive. Here we revealed that Aβ activates microglia and promotes the release of Galectin-9 (Gal-9), a member of the β-galactoside-binding family of lectins. The levels of Gal-9 in the cerebrospinal fluid and brain tissues of AD patients are higher than those in control subjects.

ACuGaS (A = Rb, Cs): Design and Synthesis of Two New Cavity-Chalcopyrite Chalcogenides Based on "Iterative Substitution" Strategy.

Two new non-centrosymmetric chalcogenides, ACuGaS (A=Rb, Cs) have been successfully synthesized by an "iterative substitution" strategy based on chalcopyrite CuFeS structural template. Benefiting from the substitution of Fe cations by Ga cations, ACuGaS (A = Rb, Cs) exhibit wide suitable band gap of 2.48 and 2.

Large Dynamic Range Spectral Measurement in Terahertz Region Based on Frequency Up-Conversion Detection via OH1 Crystal.

Terahertz spectroscopy systems, which integrate terahertz sources and detectors, have important applications in many fields such as materials science and security checking. Based on highly sensitive frequency up-conversion detection, large dynamic range spectral measurements in a terahertz region are reported. Our system realized the detection sensitivity at a 10 aJ level with a 2-(3-(4-hydroxystyryl)-5,5-dime-thylcyclohex-2-enylidene) malononitrile (OH1) crystal and a dynamic range up to seven orders.