Lower limb biomechanical differences between forehand and backhand forward lunges in amateur female badminton players.

Background: Forehand and backhand forward lunges are frequently performed in badminton, placing significant demands on the lower limbs. The purpose of this study was to examine the differences in lower limb biomechanics between these two lunge types in female amateur players.

Methods: This study involved 17 female amateur badminton players performing forehand and backhand forward lunges.

Two Material Properties from One Wavelength-Orthogonal Photoresin Enabled by a Monochromatic Laser Integrated Stereolithographic Apparatus (Mono LISA).

Multi-material printing has experienced critical advances in recent years, yet material property differentiation capabilities remain limited both with regard to the accessible properties - typically hard versus soft - and the achievable magnitude of differentiation. To enhance multi-material printing capabilities, precise photochemical control during 3D printing is essential. Wavelength-differentiation is a particularly intriguing concept yet challenging to implement.

Laparoscopic repair of parahiatal hernia: surgical techniques and literature reviews.

Purpose: Parahiatal hernia (PHH) is a rare type of diaphragmatic hernia that protrudes through a defect adjacent to, but distinct from, the esophageal hiatus. Current literature on PHH is extremely limited. In this study, we present our experience with laparoscopic repair of PHH and provide a comprehensive review of existing literature.

Can the aging process necessarily weaken the effect of biochar on cadmium-contaminated soil remediation: considering biochar at different pyrolysis temperatures and aging treatment.

Biochar has widely used to immobilize soil heavy metals in recent years, while the properties of biochar varied with environmental conditions. The influence of biochar aging on fixation and speciation transformation of Cd in soil remains unclear. This study explores how biochar aging affects the fixation and speciation transformation of Cd in soil.

Targeting YAP/TAZ-TEAD signaling as a therapeutic approach in head and neck squamous cell carcinoma.

Genetic alterations in Hippo pathway and the consequent activation of YAP/TAZ-TEAD are frequently observed in HPV-negative head and neck squamous cell carcinoma (HNSCC) patients. These include loss-of-function mutation and/or copy number loss of FAT1, and amplification of YAP1 and WWTR1 (encoding TAZ), thus raising the possibility that HNSCC cells may be dependent on YAP/TAZ-TEAD-mediated transcriptional programs. In this regard, the recent development of small molecule TEAD inhibitors (smTEADi) provides an opportunity to therapeutically target Hippo pathway dysregulation in human malignancies.

Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer's disease.

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder affecting millions of people worldwide, with no effective treatment currently available. In recent decades, various traditional Chinese medicines (TCMs) and their active ingredients have shown the potential to attenuate the pathogenesis of AD in cellular and animal models. However, the effects of TCM formulas, which are typically administered in practice, have been less studied.

Oncogenic HRAS Induces Metformin Resistance in Head and Neck Cancer by Promoting Glycolytic Metabolism.

Metformin administration has recently emerged as a candidate strategy for the prevention of head and neck squamous cell carcinoma (HNSCC). However, the intricate relationship between genetic alterations in HNSCC and metformin sensitivity is still poorly understood, which prevents the stratification of patients, harboring oral premalignant lesions that may benefit from the chemopreventive activity of metformin. In this study, we investigate the impact of prevalent mutations in HNSCC on response to metformin.

Calcium silicate hydrate complex konjac glucomannan-based hydrogel selectively adsorbed phosphate in low alkalinity solution.

The selective recovery of phosphate from wastewater can manage nutrients and realize the recycling of phosphorus resources. In this study, a novel konjac glucomannan/pectin/calcium silicate composite hydrogel (KP-CSH) was developed for efficient recovery of phosphate in aqueous solution. The amount of alkali released after the reaction of KP-CSH in a neutral solution was small (the pH of the solution after the reaction was < 9).

Decoding the origins, spread, and global risks of mcr-9 gene.

Background: The global spread of the plasmid-mediated mcr (mobilized colistin resistance) gene family presents a significant threat to the efficacy of colistin, a last-line defense against numerous Gram-negative pathogens. The mcr-9 is the second most prevalent variant after mcr-1.

Methods: A dataset of 698 mcr-9-positive isolates from 44 countries is compiled.

A genome-wide CRISPR screen reveals that antagonism of glutamine metabolism sensitizes head and neck squamous cell carcinoma to ferroptotic cell death.

Glutamine is a conditionally essential amino acid for the growth and survival of rapidly proliferating cancer cells. Many cancers are addicted to glutamine, and as a result, targeting glutamine metabolism has been explored clinically as a therapeutic approach. Glutamine-catalyzing enzymes are highly expressed in primary and metastatic head and neck squamous cell carcinoma (HNSCC).

A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC.

Unlabelled: The comprehensive genomic analysis of the head and neck squamous cell carcinoma (HNSCC) oncogenome revealed the frequent loss of p16INK4A (CDKN2A) and amplification of cyclin D1 genes in most human papillomavirus-negative HNSCC lesions. However, cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors have shown modest effects in the clinic. The aberrant activation of the PI3K/mTOR pathway is highly prevalent in HNSCC, and recent clinical trials have shown promising clinical efficacy of mTOR inhibitors (mTORi) in the neoadjuvant and adjuvant settings but not in patients with advanced HNSCC.

Metabolic engineering of Aspergillus niger for accelerated malic acid biosynthesis by improving NADPH availability.

Microbial production of L-malic acid from renewable carbon sources has attracted extensive attention. The reduced cofactor NADPH plays a key role in biotransformation because it participates in both biosynthetic reactions and cellular stress responses. In this study, NADPH or its precursors nicotinamide and nicotinic acid were added to the fermentation medium of Aspergillus niger RG0095, which significantly increased the yield of malic acid by 11%.

The forced activation of asexual conidiation in simplifies bioproduction.

is an efficient cell factory for organic acids production, particularly l-malic acid, through genetic manipulation. However, the traditional method of collecting spores for inoculation is labor-intensive and resource-consuming. In our study, we used the CRISPR-Cas9 system to replace the promoter of , a key gene in conidiation, with a xylose-inducible promoter in l-malic acid-producing strain RG0095, generating strain .

CHEK2 knockout is a therapeutic target for TP53-mutated hepatocellular carcinoma.

Currently, there is still a lack of novel and effective drug targets to improve the prognosis of hepatocellular carcinoma (HCC). Additionally, the role of CHEK2 in HCC has not been reported yet. The eQTLgen database and two HCC Genome-Wide Association Study (GWAS) datasets (ieu-b-4953, ICD10 C22.

Restricted reaction of layered double hydroxide nanoparticles with phosphate in a confined microsphere space.

Over the past decades, considerable efforts have been made to find useful solutions for phosphate pollution control. The state transition of nanomaterials from freely dispersed to encapsulated provides a realizable route for their application in phosphate elimination. The separation convenience offered by encapsulation has been widely recognized, however, the unique binding mode of nanostructures and phosphate in the confined space remains unclear, limiting its further development.

Increase in antioxidant capacity associated with the successful subclone of hypervirulent carbapenem-resistant Klebsiella pneumoniae ST11-KL64.

The acquisition of exogenous mobile genetic material imposes an adaptive burden on bacteria, whereas the adaptational evolution of virulence plasmids upon entry into carbapenem-resistant Klebsiella pneumoniae (CRKP) and its impact remains unclear. To better understand the virulence in CRKP, we characterize virulence plasmids utilizing a large genomic data containing 1219 K. pneumoniae from our long-term surveillance and publicly accessible databases.

Molecular Simulation of Thermodynamic Properties of CH/CO Adsorption by Coal Molecules at Different Temperatures and Moisture Contents under Variable Pressure Conditions.

In order to further elucidate the thermodynamic mechanism of CH/CO adsorption by coal molecules, the adsorption behavior of a molecular model of coal (CHON) at Wucaiwan, Zhundong was investigated by applying Materials Studio 2020 and Monte Carlo (GCMC) simulation methods, and the adsorption behavior of CH and CO was studied from the thermodynamic point of view under the conditions of different temperatures, pressures, and moisture contents. The results showed that at different temperatures or moisture contents, CH molecules had a low-density scattering distribution and CO molecules had a high-density polymerization distribution. Temperature and moisture content and adsorption constants a and b were negatively correlated.

Anion Exchange Membranes for Hydrogen Technologies: Challenges and Progress.

Anion exchange membrane fuel cells (AEMFCs) are considered one of the most promising and efficient hydrogen conversion technologies due to their ability to use cost-effective materials. However, AEMFCs are still in the early stage of development and the lack of suitable anion exchange membranes (AEMs) is one major obstacle. In this review, we highlight three major challenges in AEMs development and discuss recent scientific advancements that address these challenges.

Fluorescence-readout as a powerful macromolecular characterisation tool.

The last few decades have witnessed significant progress in synthetic macromolecular chemistry, which can provide access to diverse macromolecules with varying structural complexities, topology and functionalities, bringing us closer to the aim of controlling soft matter material properties with molecular precision. To reach this goal, the development of advanced analytical techniques, allowing for micro-, molecular level and real-time investigation, is essential. Due to their appealing features, including high sensitivity, large contrast, fast and real-time response, as well as non-invasive characteristics, fluorescence-based techniques have emerged as a powerful tool for macromolecular characterisation to provide detailed information and give new and deep insights beyond those offered by commonly applied analytical methods.

Color-tunable luminescence based on the efficient energy transfer of a Tm-Dy system for optical thermometry and white LED lighting.

The development of phosphors with color-tunable luminescence including white emission is at the forefront of lighting and display technologies. Herein, Dy,Tm single-doped or co-doped KY(PO) phosphors are synthesized through the solid-state reaction method. By properly adjusting the ratio of Dy,Tm co-doping concentrations, color-tunable luminescence from blue to yellow, including white luminescence, is realized under 359 nm excitation.

Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor.

β-arrestins play a key role in G protein-coupled receptor (GPCR) internalization, trafficking, and signaling. Whether β-arrestins act independently of G protein-mediated signaling has not been fully elucidated. Studies using genome-editing approaches revealed that whereas G proteins are essential for mitogen-activated protein kinase activation by GPCRs.

Direct tuning of soliton detuning in an ultrahigh- MgF crystalline resonator.

The dissipative Kerr soliton combs based on microresonators have attracted wide attention due to their high coherence and on-chip integration. Meanwhile, the soliton microcombs have shown broad applications in coherent communication, on-chip low-noise microwave synthesizer, optical clock, etc. However, the performance of these applications is typically limited by their bandwidth as the precise tuning of the soliton microcombs usually relies on the thermoelectric cooler, which is slow and may increase the system's complexity.

Konjac glucomannan/pectin/Ca-Mg hydrogel with self-releasing alkalinity to recover phosphate in aqueous solution.

The combination of polysaccharides can obtain stable, degradable, and environmentally friendly hydrogels, which have broad application prospects in adsorbents assembly. With Ca and Mg as crosslinkers, a new pectin/Konjac glucomannan/Ca-Mg composite hydrogel was prepared for phosphate adsorption by the alkali-thermal co-reaction method. Since Mg(OH) can create a suitable pH condition for phosphate adsorption by Ca, Ca and Mg synergistically promoted phosphate adsorption and remained stable in the pH range of 4 to 10.