Femtosecond laser direct writing tilted fiber Bragg gratings in multicore fiber.

In this Letter, we propose a new method utilizing femtosecond laser direct writing technology to rapidly inscribe high-quality tilted fiber Bragg gratings (TFBGs) in multicore fibers (MCFs). A series of TFBGs with varying tilt angles were directly inscribed in MCFs using the Plane-by-Plane (Pl-by-Pl) method, and the writing time for a 4 mm long TFBG was only 3.60 s.

Trio-based whole-exome sequencing of 200 Chinese patients with keratoconus.

Keratoconus (KC) is a complex corneal disorder with a well-recognized genetic component. In this study, we aimed to expand the genetic spectrum of 200 Chinese patients with keratoconus and their unaffected parents. Trio-based whole-exome sequencing was performed in 200 patients with sporadic keratoconus and their unaffected parents.

Function of mast cell and bile-cholangiocarcinoma interplay in cholangiocarcinoma microenvironment.

Objective: The correlation between cholangiocarcinoma (CCA) progression and bile is rarely studied. Here, we aimed to identify differential metabolites in benign and malignant bile ducts and elucidate the generation, function and degradation of bile metabolites.

Design: Differential metabolites in the bile from CCA and benign biliary stenosis were identified by metabonomics.

Nomogram to predict severe retinopathy of prematurity in Southeast China.

Aim: To define the predictive factors of severe retinopathy of prematurity (ROP) and develop a nomogram for predicting severe ROP in southeast China.

Methods: Totally 554 infants diagnosed with ROP hospitalized in the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University and hospitalized in Taizhou Women and Children's Hospital were included. Clinical data and 43 candidate predictive factors of ROP infants were collected retrospectively.

Bile exosomal miR-182/183-5p increases cholangiocarcinoma stemness and progression by targeting HPGD and increasing PGE2 generation.

Background Aims: Cholangiocarcinoma (CCA) is a highly lethal malignancy originating from the biliary ducts. Current CCA diagnostic and prognostic assessments cannot satisfy the clinical requirement. Bile detection is rarely performed, and herein, we aim to estimate the clinical significance of bile liquid biopsy by assessing bile exosomal concentrations and components.

Two-dimensional displacement (bending) sensor based on cascaded Fabry-Perot interferometers fabricated in a seven-core fiber.

We demonstrated a two-dimensional vector displacement (bending) sensor with high angular resolution based on Vernier effect generated by two cascaded Fabry-Perot interferometers (FPI) in a seven-core fiber (SCF). To form the FPI, plane-shaped refractive index modulations are fabricated as the reflection mirrors in the SCF using slit-beam shaping and femtosecond laser direct writing. Three pairs of cascaded FPIs are fabricated in the center core and the two non-diagonal edge cores of the SCF and applied to the vector displacement measurement.

HOXA-AS2 may be a potential prognostic biomarker in human cancers: A meta-analysis and bioinformatics analysis.

Dysregulation of long non-coding (lncRNA) has been reported in various solid tumors. HOXA cluster antisense RNA 2 (HOXA-AS2) is a newly identified lncRNA with abnormal expression in several human malignancies. However, its prognostic value remains controversial.

Research progress of bile biomarkers and their immunoregulatory role in biliary tract cancers.

Biliary tract cancers (BTCs), including cholangiocarcinoma and gallbladder carcinoma, originate from the biliary epithelium and have a poor prognosis. Surgery is the only choice for cure in the early stage of disease. However, most patients are diagnosed in the advanced stage and lose the chance for surgery.

BMI1 promotes cholangiocarcinoma progression and correlates with antitumor immunity in an exosome-dependent manner.

Background: Cholangiocarcinoma (CCA) is a class of malignant tumors originating from bile duct epithelial cells. Due to difficult early diagnosis and limited treatment, the prognosis of CCA is extremely poor. BMI1 is dysregulated in many human malignancies.

Bragg grating in a flexible and stretchable coreless polymer optical fiber.

In this Letter, we propose and experimentally demonstrate fiber Bragg grating (FBG) fabrication in a flexible and stretchable coreless polymer optical fiber. The flexible polymer optical fiber is prepared with polydimethylsiloxane (PDMS). Femtosecond laser direct writing and slit beam shaping are used to form periodic grating structures in the fiber.

Femtosecond laser plane-by-plane inscribed ultrahigh-order fiber Bragg grating and its application in multi-wavelength fiber lasers.

We propose an ultrahigh-order fiber Bragg grating (UHO-FBG) containing dense resonants and its application as a novel filtering device in multi-wavelength lasers. The UHO-FBG is fabricated by femtosecond laser plane-by-plane direct inscription. Thanks to the plane-by-plane inscription, high-order Bragg resonances can be formed with multiple reflectance peaks of comparable reflectance in the range of the fiber operating bandwidth and without the transmission depression of long-period gratings in the transmission spectrum.

Wnt-TCF7-SOX9 axis promotes cholangiocarcinoma proliferation and pemigatinib resistance in a FGF7-FGFR2 autocrine pathway.

Cholangiocarcinoma (CCA) is a type of highly malignant tumor originating from bile ducts. The prognosis of CCA is poor and the treatment options are limited. The biomarker study of CCA has made little progresses in recent years because of the difficulty to obtain CCA specimens.

Femtosecond laser point-by-point inscription of helical-sampled fiber Bragg gratings.

In this Letter, a helical-sampled fiber Bragg gratings (HSFBGs) fabrication using a femtosecond laser point-by-point (PBP) technique is proposed. The unique helical structure generates sampled gratings owing to its periodicity. A simple, single-step method for inscription of the sampled gratings is described.

Vector bending sensor based on an edge-core cladding-type fiber Bragg grating.

A two-dimensional vector bending sensor that is both compact and simple is proposed and demonstrated, based on an edge-core cladding-type fiber Bragg grating (ECLFBG) inscribed in an edge-core. The ECLFBG is written parallel to the edge-core using a femtosecond laser point-by-point technique. The reflection spectrum of this ECLFBG varies significantly depending on the magnitude and direction of the fiber's bend.

The Smad4-MYO18A-PP1A complex regulates β-catenin phosphorylation and pemigatinib resistance by inhibiting PAK1 in cholangiocarcinoma.

Cholangiocarcinoma (CCA), consisting of three subtypes-intrahepatic (iCCA), perihilar (pCCA), and distal (dCCA), is a highly aggressive cancer arising from the bile duct and has an extremely poor prognosis. Pemigatinib is the only FDA-approved targeted drug for CCA, and the CCA treatment options are substantially insufficient considering its poor prognosis and increasing morbidity. Here, we performed next-generation sequencing (NGS) of 15 pCCAs and 16 dCCAs and detected the expression of SMAD4, a frequently mutated gene, in 261 CCAs.

Orientation-dependent fiber-optic accelerometer based on eccentric fiber Bragg grating.

A highly localized eccentric fiber Bragg grating (EFBG) accelerometer was proposed, and its orientation-dependent measurement results were demonstrated experimentally. An EFBG was inscribed point-by-point (PbP) in a single-mode fiber (SMF) using a femtosecond laser, and the cladding mode was recoupled to excite the ghost mode through an abrupt taper. Owing to the asymmetry caused by the lateral offset of the EFBG, the ghost mode showed a significant directional response to acceleration.

Direct femtosecond laser inscription of an IR fluorotellurite fiber Bragg grating.

This study proposes a novel, to the best of our knowledge, development of fluorotellurite glass fiber Bragg gratings (FBGs). Shell-like morphology was achieved using a single femtosecond laser pulse illuminated through the fiber's polymer coating. Different FBG fabrication methods and parameters were systematically studied to optimize performance.

Genetic Screening Revealed Latent Keratoconus in Asymptomatic Individuals.

Purpose: To adopt molecular screening in asymptomatic individuals at high risk of developing keratoconus as a combinative approach to prevent subclinical patients from post-refractive surgery progressive corneal ectasia.

Methods: In this study, 79 Chinese and nine Greek families with keratoconus were recruited, including 91 patients with clinically diagnosed keratoconus as well as their asymptomatic but assumptive high-risk first-degree relatives based on underlying genetic factor. Mutational screening of , , and genes and full clinical assessment including Pentacam Scheimpflug tomography were carried out in these individuals.

Two-dimensional vector accelerometer based on orthogonal Bragg gratings inscribed in a standard single-mode fiber cladding.

We propose and demonstrate a novel, to the best of our knowledge, two-dimensional vector accelerometer based on orthogonal cladding fiber Bragg gratings (FBGs) inscribed in a standard single-mode fiber (SMF). The cladding FBGs are written by a femtosecond laser point-by-point technique and run parallel with the core. We experimentally demonstrate that the two orthogonal components of acceleration can be directly detected using simplified power-referenced detection.