Publications by authors named "Xingyi Zhong"
Article Synopsis
- EFNA4 influences liver cancer (HCC) through two mechanisms: one that binds to Eph receptors and another that operates independently of them.
- Despite a lack of Eph receptors, EFNA4 still promotes HCC cell growth and spread as well as inhibiting ferroptosis, a type of cell death.
- The study reveals that EFNA4 interacts with the protein SLC7A11 to prevent its degradation, enhancing HCC progression and suggesting EFNA4 as a potential marker and target for HCC treatment.
Background: EphrinA5 belongs to a subclass of ephrin ligands. Abnormal signal transduction of EFNA5 shows a relationship to the development of various tumors. In this study, we explored the level of EFNA5 in hepatoma cells and the influence of up regulation of EFNA5 expression level on the proliferation, invasion, and migration of HepG2 and LM3 cells.
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