Publications by authors named "Xingxing Zheng"

Background: Lung cancer continues to pose a serious risk to human health. With a high mortality rate, non-small cell lung cancer (NSCLC) is the major type of lung cancer, making up to 85% of all cases of lung cancer. Lung adenocarcinoma (AC), and lung squamous cell carcinoma (SC) are the two primary types of NSCLC.

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  • The study addresses the challenge of converting CO2 to methane (CH4) using solar energy by modifying g-C3N4 with different types of phosphotungstates (PWx).
  • It finds that higher lacunae in phosphotungstates increase the selectivity and yield of CH4, with PW9/g-C3N4 achieving 80% selectivity and a rate of 40.8 μmol·g-1·h-1.
  • The conversion process involves a two-step catalytic mechanism where CO2 is activated by g-C3N4 to form *CO intermediates, which are then converted to CH4 through interactions with the modified phosphotungstates.
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Introduction: The angiotensin-converting enzyme 2 (ACE2), which is expressed in cerebral vascular endothelial cells (CVECs), has been currently identified as a functional receptor for SARS-CoV-2.

Methods: We specifically induced injury to ACE2-expressing CVECs in mice and evaluated the effects of such targeted damage through magnetic resonance imaging (MRI) and cognitive behavioral tests. In parallel, we recruited a single-center cohort of COVID-19 survivors and further assessed their brain microvascular injury based on cognition and emotional scales, cranial MRI scans, and blood proteomic measurements.

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It's currently a challenge to design a drug delivery system for chemotherapy with high drug contents and minimal side effects. Herein, we constructed a novel one-dimensional binary-drug delivery system for cancer treatment. In this drug delivery system, drugs (doxorubicin (DOX) and resveratrol (RES)) self-assemble on bacterial cellulose nano-whiskers (BCW) and are subsequently encapsulated by polydopamine (PDA) with high encapsulation efficiencies (DOX: 81.

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Toxoplasma gondii (T.gondii) can influence the host's neurotransmission, central immune responses, and brain structure, potentially impacting the onset and development of various psychiatric disorders such as schizophrenia. We employed Electrochemiluminescence Immunoassay (ECLIA) to measure anti-Toxoplasma antibodies in 451 schizophrenic patients and 478 individuals from the general population in Hunan, China.

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Hypobaric hypoxia is the main cause of high-altitude retinopathy (HAR). Retinal oedema is the key pathological change in HAR. However, its pathological mechanism is not clear.

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  • This study developed a stacking model to predict how axillary lymph nodes respond to neoadjuvant chemotherapy in breast cancer, utilizing MRI data.
  • The analysis involved 1,153 patients, with the model showing strong accuracy in distinguishing responses and a notably lower false-negative rate compared to traditional radiologists.
  • Results indicated significant differences in disease-free survival between high-risk and low-risk groups, suggesting the model's potential for enhancing patient outcomes post-chemotherapy.
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Mitogen-activated protein kinase (MAPK) signalling cascades are functionally important signalling modules in eukaryotes. Transcriptome reprogramming of immune-related genes is a key process in plant immunity. Emerging evidence shows that plant MAPK cascade is associated with processing (P)-body components and contributes to transcriptome reprogramming of immune-related genes.

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The pathogenesis of neuropathic pain (NP) is complex, and there are various pathological processes. Previous studies have suggested that lncRNA PCAT19 is abnormally expressed in NP conduction and affects the occurrence and development of pain. The aim of this study is to analyze the role and mechanism of PCAT19 in NP induced by chronic compressive nerve injury (CCI) in mice.

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Patient-derived organoids (PDOs) may facilitate treatment selection. This retrospective cohort study evaluated the feasibility and clinical benefit of using PDOs to guide personalized treatment in metastatic breast cancer (MBC). Patients diagnosed with MBC were recruited between January 2019 and August 2022.

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Objective: To develop an artificial intelligence (AI) system for the early prediction of residual cancer burden (RCB) scores during neoadjuvant chemotherapy (NAC) in breast cancer.

Summary Background Data: RCB III indicates drug resistance in breast cancer, and early detection methods are lacking.

Methods: This study enrolled 1048 patients with breast cancer from four institutions, who were all receiving NAC.

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Translation elongation factor P, expressed by the efp gene, is a conserved protein closely related to bacterial virulence and environmental stress regulation responses, however, little is known about the efp gene expression regulations. Here, the strain of Staphylococcus aureus subsp. aureus NCTC 8325 was taken as the research object and cultured under different conditions, including different culture temperatures, pH, and antibiotics, to study the expression of the efp gene in S.

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Background: The Index of Consciousness (IoC) is a new monitoring index of anesthesia depth reflecting the state of consciousness of the brain independently developed by China. The research on monitoring the depth of anesthesia mainly focuses on propofol, and bispectral index (BIS) is a sensitive and accurate objective index to evaluate the state of consciousness at home and abroad. This study mainly analyzed the effect of IoC on monitoring the depth of sevoflurane anesthesia and the consistency and accuracy with BIS when monitoring sevoflurane maintenance anesthesia.

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  • - High altitude retinopathy (HAR) is a common eye issue that typically occurs when people ascend to high altitudes, with symptoms like retinal vascular dilatation, edema, and occasional hemorrhage; vision is usually not severely affected.
  • - Current research focuses on factors like blood flow changes, damage to the blood-retinal barrier, oxidative stress, and inflammation, indicating that HAR is related to hypoxia, especially when altitude increases.
  • - The correlation of HAR with altitude-related illnesses such as acute mountain sickness (AMS) and high-altitude cerebral edema (HACE) highlights the importance of understanding HAR, as proper ascent strategies and medical insights from both traditional Chinese medicine and Western medicine can help in prevention and treatment. *
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Background: Osteoporosis (OP) poses a significant clinical challenge with escalating morbidity. This study explores Circ_HECW2 expression in OP patients and its regulatory role in lipopolysaccharide (LPS)-induced osteoblast apoptosis.

Methods: Circ_HECW2 expression in OP patient serum and healthy controls was quantified using RT-qPCR.

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Background: This study aimed to assess whether a combined model incorporating radiomic and depth features extracted from PET/CT can predict disease-free survival (DFS) in patients who failed to achieve pathologic complete response (pCR) after neoadjuvant chemotherapy.

Results: This study retrospectively included one hundred and five non-pCR patients. After a median follow-up of 71 months, 15 and 7 patients experienced recurrence and death, respectively.

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Purpose: This study aims to explore whether neoadjuvant chemotherapy with immunotherapy (NACI) leads to different tumor shrinkage patterns, based on magnetic resonance imaging (MRI), compared to neoadjuvant chemotherapy (NAC) alone in patients with triple-negative breast cancer (TNBC). Additionally, the study investigates the relationship between tumor shrinkage patterns and treatment efficacy was investigated.

Methods: This retrospective study included patients with TNBC patients receiving NAC or NACI from January 2019 until July 2021 at our center.

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  • * This study focused on five cardiac glycosides extracted from plants, with lanatoside C (Lan C) identified as the most effective in inhibiting the growth and inducing apoptosis in CCA cells.
  • * The mechanism of Lan C's anticancer activity involved increasing reactive oxygen species, altering mitochondrial potential, and modulating specific protein expressions, ultimately leading to reduced tumor growth without harming normal cells.
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High-throughput assays play an important role in the fields of drug discovery, genetic analysis, and clinical diagnostics. Although super-capacity coding strategies may facilitate labeling and detecting large numbers of targets in a single assay, practically, the constructed large-capacity codes have to be decoded with complicated procedures or are lack of survivability under the required reaction conditions. This challenge results in either inaccurate or insufficient decoding outputs.

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Background: To investigate the value of preoperative computed tomography (CT) texture features, routine imaging features, and clinical features in the prognosis of non-small cell lung cancer (NSCLC) after radical resection.

Methods: Demographic parameters and clinically features were analyzed in 107 patients with stage I-IIIB NSCLC, while 73 of these patients received CT scanning and radiomic characteristics for prognosis assessment. Texture analysis features include histogram, gray size area matrix and gray co-occurrence matrix features.

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Background: Accurate identification of pCR to neoadjuvant chemotherapy (NAC) is essential for determining appropriate surgery strategy and guiding resection extent in breast cancer. However, a non-invasive tool to predict pCR accurately is lacking. Our study aims to develop ensemble learning models using longitudinal multiparametric MRI to predict pCR in breast cancer.

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Background: Evidence for the preferred neoadjuvant therapy regimen in triple-negative breast cancer (TNBC) is not yet established.

Methods: Literature search was conducted from inception to February 12, 2022. Phase 2 and 3 randomized controlled trials (RCTs) investigating neoadjuvant therapy for TNBC were eligible.

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Introduction: Falls are prevalent in patients with Parkinson disease (PD). Previous work focused on the impact of motor and non-motor symptoms on falls and ignored the impact of environmental factors, such as residence, economic level, and nursing status. The aim of this study was to investigate the prevalence and risk factors of falls in patients with PD and explore the impact of residence on falls.

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Although the digital transformation is advancing, a significant portion of the population in all countries of the world is not familiar with the technological means that allow malicious users to deceive them and gain great financial benefits using phishing techniques. Phishing is an act of deception of Internet users. The perpetrator pretends to be a credible entity, abusing the lack of protection provided by electronic tools and the ignorance of the victim (user) to illegally obtain personal information, such as bank account codes and sensitive private data.

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One of the most insidious methods of bypassing security mechanisms in a modern information system is the domain generation algorithms (DGAs), which are used to disguise the identity of malware by periodically switching the domain name assigned to a command and control (C&C) server. Combating advanced techniques, such as DGAs, is an ongoing challenge that security organizations often need to work with and possibly share private data to train better and more up-to-date machine learning models. This logic raises serious concerns about data integrity, trade-related issues, and strict privacy protocols that must be adhered to.

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