Publications by authors named "Xingwu Zou"
Article Synopsis
- This text discusses a rare case of cryptococcal osteomyelitis in a 67-year-old woman, complicated by tuberculosis, that was challenging to diagnose due to its similarity to other lung infections.
- Metagenomic Next-Generation Sequencing (mNGS) was used to accurately identify the infection after a biopsy, confirming the presence of Cryptococcus neoformans through additional tests.
- The case highlights the importance of advanced genomic techniques in diagnosing complex infections and shows that cryptococcal osteomyelitis, while rare, can be effectively treated with surgery and antifungal medication.
Article Synopsis
- A study evaluated the effectiveness of endobronchial ultrasound-guided transbronchoscopic lung biopsy (EBUS-TBLB) for diagnosing pulmonary tuberculosis in patients with suspected intrapulmonary nodules.
- Conducted from January 2022 to January 2023, the study involved 107 patients whose lung biopsy samples were tested using multiple diagnostic methods, including next-generation sequencing (NGS) and Xpert MTB/RIF.
- Results showed that EBUS-TBLB had an overall diagnostic rate of 80.37%, with NGS demonstrating the highest accuracy in diagnosis, correlating well with clinical outcomes.
Article Synopsis
- This study assessed the effectiveness of nanopore sequencing for early diagnosis of tuberculous meningitis (TBM) using cerebrospinal fluid, comparing it to traditional methods like AFB smear and culture.
- Conducted at a hospital specialized in tuberculosis, the study included 64 adult patients suspected of having TBM between August 2021 and August 2023.
- Results showed that nanopore sequencing had a sensitivity of 77.78% and a negative predictive value of 65.52%, outperforming AFB smear and other conventional tests in diagnosing TBM.
Article Synopsis
- This study assessed the effectiveness of nanopore sequencing for diagnosing pulmonary tuberculosis (PTB) using bronchoalveolar lavage fluid (BALF) samples, comparing it to traditional methods like smear and culture tests.
- The analysis involved 195 patients with suspected PTB, calculating various diagnostic metrics for each method, including sensitivity and specificity.
- Results showed nanopore sequencing outperformed other methods, highlighting its potential to enhance clinical diagnosis, especially in cases where sputum samples are limited.
Value analysis of next-generation sequencing combined with Xpert in early precise diagnosis of pulmonary tuberculosis.
Diagn Microbiol Infect Dis
September 2023
Article Synopsis
- - This study examines how effectively combining next-generation sequencing (NGS) with the Xpert MTB/RIF test can diagnose early pulmonary tuberculosis (PTB) in 85 patients suspected of having the disease.
- - Results showed that the combination methods (Xpert MTB/RIF, TBseq Ultra, TB-DNA, TB-RNA) had significantly higher detection rates and accuracy compared to traditional acid-fast staining techniques.
- - The research concluded that using both Xpert MTB/RIF and TBseq Ultra together enhances diagnostic sensitivity and specificity, making it a promising approach for early PTB diagnosis with an impressive ROC curve value of 0.886.
Article Synopsis
- * Of the 44 patients with detected lesions through EBUS-TBLB, 26 were accurately diagnosed, yielding a 59.1% success rate, and 22 out of 33 diagnosed benign cases turned out to be active tuberculosis, resulting in a 66.7% diagnostic yield.
- * The research highlighted that the bronchoalveolar lavage fluid (BALF) had a higher diagnostic rate compared to tissue samples, with a notable 95.6% positive rate, suggesting that EBUS-T
Article Synopsis
- * Various factors were analyzed for their impact on BaF formation, including pH, molar ratios, and concentrations of different chemicals, with an average spherical size of 346.9 nm observed.
- * The research proposed a self-assembly mechanism for the spherical structure, highlighting the critical role of EDTA and identifying optimal synthesis conditions for producing BaF.
Article Synopsis
- A meta-analysis was conducted to explore the link between the interleukin-8 -251A/T polymorphism and the risk of tuberculosis (TB), as previous findings were inconsistent.
- The analysis revealed that the -251A/T polymorphism significantly increases the risk of TB, particularly in African populations, while no significant association was found in Asian populations.
- The study suggests that the -251A/T polymorphism may be a contributing factor to TB risk, but larger studies are needed to validate these findings.