Knockdown of YAP1 Reduces YTHDF3 to Stabilize and thus Inhibit Bladder Cancer Stem Cell Stemness.

Background: The previous study has proved the oncogenic role of Yes-associated protein 1 (YAP1) in bladder cancer (BLCA), thus this study focused on its impact on bladder cancer stem cells (BCSCs) and underlying mechanism.

Method: BCSCs were obtained by treating human BLCA cells UMUC3 with cisplatin and identified by measuring CD133 in UMUC3/BCSCs via flow cytometry. YAP1 interaction proteins and mothers against decapentaplegic homolog 7 () N6-methyladenosine (m6A) site were analyzed by bioinformatics.

Mitochondrial metabolism-related signature depicts immunophenotype and predicts therapeutic response in testicular germ cell tumors.

In recent years, there has been growing evidence linking mitochondrial dysfunction to the development and progression of cancer. However, the role of mitochondrial metabolism-related genes (MMRGs) in testicular germ cell tumor (TGCT) remains unclear. We downloaded clinical pathology, transcriptome, and somatic mutation data for TGCT from public databases and conducted univariate Cox regression analysis to investigate prognostic correlations.

miR-20b promotes cellular proliferation and migration by directly regulating phosphatase and tensin homolog in prostate cancer.

MicroRNAs are small non-coding RNAs, which are critical regulators of carcinogenesis and tumor progression. Previous studies have identified that microRNA-20b (miR-20b) acts as an oncogene in numerous cancers. However, the role of miR-20b in prostate cancer remains unclear.

Repair of Bile Duct Injury With Autologous Vein Graft and Stent.

Objectives: We investigated the effects of autologous vein transplant on bile duct injury repair, through observation of the hepatic and biliary system tissue morphology changes and animal survival after bile duct injury repair.

Materials And Methods: Rabbits were equally divided into groups. Group A had cholecystectomy and common bile duct resection (length of 0.

MicroRNA-223-3p inhibits human bladder cancer cell migration and invasion.

The regulation of initiation and progression during carcinogenesis of bladder carcinoma is not completely elucidated. Dysregulation of microRNAs has been detected to play critical roles in the development of various cancers, including bladder carcinoma, whereas the involvement of miR-223-3p in the tumorigenesis of bladder carcinoma has not been studied. Here, we show that significantly higher levels of nuclear receptor coactivator 1 and significantly lower levels of miR-223-3p were detected in bladder carcinoma tissue, compared to the adjacent non-tumor tissue.

High-performance membranes with multi-permselectivity for CO2 separation.

Multi-permselective membranes with diffusivity-selectivity, solubility-selectivity, and reactivity-selectivity for CO(2) separation are prepared by interfacial polymerization. The membranes are able to efficiently separate CO(2) from various light gases (H(2) , CH(4) and N(2) ) due to the optimized membrane structure and the comprehensive utilization of distinctions between CO(2) and light gases in size, condensability, and reactivity.