Publications by authors named "Xingwang Ji"
Central nervous system (CNS) disorders confront significant challenges in drug delivery due to the blood-brain barrier (BBB). Inspired by the rapid and precise binding of odor molecules to olfactory receptors (ORs), this research uses thiolated HPMA to construct odor nanoparticles (nanoodors) capable of delivering drugs to the CNS via the olfacto-cerebral pathway to overcome the delivery obstruction. The nanoodor core is used to encapsulate agomelatine (AGO), a CNS-targeting antidepressant, and the encapsulation efficiency exceeded 80%.
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- * Results showed that curcumin significantly reduced levels of markers like CK-MB, CK, LDH, and MDA, while improving heart function indicators such as LVEF and LVFS, and decreasing various cardiac stress markers.
- * Despite these positive outcomes, the overall quality of evidence was low, with none of the studies demonstrating a low risk of bias; curcumin did not notably affect heart rate or SOD levels.