Publications by authors named "Xingting Yan"
Eur J Med Chem
December 2024
Article Synopsis
- Idiopathic pulmonary fibrosis (IPF) is a serious lung disease with no known cause, leading to lung damage and scarring due to inflammation and structural changes.
- Triptolide (TP) has anti-inflammatory properties, but its clinical use is limited due to poor solubility and side effects; however, new water-soluble TP derivatives called TP-DEAs have been developed for better effectiveness.
- TP-DEA2, a specific derivative, shows high solubility and can inhibit key proteins related to fibrosis without toxic effects, indicating its potential as a treatment for IPF, especially when administered later in the disease progression.
