Effects of acute PM purification on cognitive function and underlying mechanisms: Evidence from integrating alternative splicing into multi-omics.

The relationship between fine particulate matter (PM) and cognition has been extensively investigated. However, the causal impact of acute PM purification on cognition improvement and the underlying biological mechanisms remain relatively opaque. Our double-blinded randomized controlled trial assessed the impact of acute PM purification on executive function, underpinned by multi-omics approaches including alternative splicing (AS) analysis.

Substitution of physical activity for sedentary behaviour contributes to executive function improvement among young adults: a longitudinal study.

Background: Sedentary lifestyles may affect cognitive capacities which are essential for daily tasks. There is a lack of research on the effects of replacing sedentary behaviour with physical activity on executive function, as well as the dose-response relationship between physical activity and executive function among young adults, underscoring the critical need for prompt investigation.

Methods: Employing a longitudinal experimental design, the study conducted two assessments (baseline and at three months) on a cohort of participants.

Exploring the potential relationship between short sleep risks and cognitive function from the perspective of inflammatory biomarkers and cellular pathways: Insights from population-based and mice studies.

Aims: The molecular mechanism of short-sleep conditions on cognition remains largely unknown. This research aimed to investigate associations between short sleep, inflammatory biomarkers and cognitive function in the US population (NHANES data 2011-2014) and explore cellular mechanisms in mice.

Methods: Systemic immune-inflammation index (SII) was calculated using blood-cell based biomarkers.

Relationship between accelerometer-measured sleep duration and Stroop performance: a functional near-infrared spectroscopy study among young adults.

Objectives: Short sleep is becoming more common in modern society. This study aimed to explore the relationship between accelerometer-measured sleep duration and cognitive performance among young adults as well as the underlying hemodynamic mechanisms.

Methods: A total of 58 participants were included in this study.

The joint effect and hemodynamic mechanism of PA and PM exposure on cognitive function: A randomized controlled trial study.

Background: While PM has been shown to impair cognitive function, physical activity (PA) is known to enhance it. Nonetheless, considering the increased inhalation of PM during exercise, the potential of PA to counteract the detrimental effects of PM, along with the underlying hemodynamic mechanisms, remains uncertain.

Methods: We conducted a double-blinded, randomized controlled trial among healthy young adults in Beijing, China.

The association between sedentary behavior, exercise, and sleep disturbance: A mediation analysis of inflammatory biomarkers.

Background: Two related lifestyle behaviors associated with sleep disturbance are sedentary behavior and physical exercise participation. We aimed to use a population-based study to disentangle the relationships between sedentary behavior, exercise, and sleep disturbance based on blood-cell-based inflammatory biomarkers.

Methods: A total of 22,599 participants from the National Health and Nutrition Examination Survey (NHANES) were included in the analyses.

Exercise improves mental health status of young adults attenuating inflammation factors but modalities matter.

Introduction: The mental health of young adults is a global public health challenge. Numerous studies have demonstrated that exercise benefits mental health. However, it is still unclear which exercise mode is optimal for protecting mental health and its association with the immune system.

Codon-optimized FAM132b gene therapy prevents dietary obesity by blockading adrenergic response and insulin action.

Background: FAM132b (myonectin) has been identified as a muscle-derived myokine with exercise and has hormone activity in circulation to regulate iron homeostasis and lipid metabolism via unknown receptors. Here, we aim to explore the potential of adeno-associated virus to deliver FAM132b in vivo to develop a gene therapy against obesity.

Methods: Adeno-associated virus AAV9 were engineered to induce overexpression of FAM132b with two mutations, A136T and P159A.

Bibliometric Review to Explore Emerging High-Intensity Interval Training in Health Promotion: A New Century Picture.

High-intensity interval training (HIIT) is an emerging exercise strategy and is considered to be a recipe for health promotion. This study aimed to systematically identify collaboration networks, track research trends, highlight current hotspots, and predict future frontiers in HIIT and its applications in health promotion since the start of the new century. Relevant original publications were obtained from the Science Citation Index Expanded of the Web of Science Core Collection (WoSCC) database between 2001 and 2020.