The positive correlation between amphiregulin and insulin resistance.

Objective: Obesity and insulin resistance carry a high risk of progressing to type 2 diabetes mellitus. A lot of evidence has tightly associated insulin resistance with chronic inflammation. Besides, it has been reported that the activation of amphiregulin epidermal growth factor receptor pathways is involved in chronic inflammation.

High-Glucose-Induced Injury to Proximal Tubules of the Renal System Is Alleviated by Netrin-1 Suppression of Akt/mTOR.

The kidneys have a high level of Netrin-1 expression, which protects against some acute and chronic kidney disorders. However, it is yet unknown how Netrin-1 affects renal proximal tubule cells in diabetic nephropathy (DN) under pathological circumstances. Research has shown that autophagy protects the kidneys in animal models of renal disease.

Uric acid is independently associated with interleukin-1β levels in tear fluid of hyperuricemia and gout patients.

Objectives: To explore pro-inflammatory cytokines status in the tear fluid of patients with hyperuricemia and gout and its association with uric acid level.

Methods: A total of 58 control subjects, 58 hyperuricemia patients including 40 asymptomatic hyperuricemia and 18 gout participants were recruited in this study. For tear analysis, each patient's tears were collected using capillary action microcaps after stimulation.

Autoimmune polyglandular syndrome type 1 with diabetes insipidus: a case report.

Background: Autoimmune polyendocrine syndrome type 1 (APS-1) is a rare monogenic inherited disease caused by mutations of the autoimmune regulator gene (AIRE). The three major components of this syndrome are chronic mucocutaneous candidiasis, hypoparathyroidism and adrenocortical insufficiency.

Case Presentation: We report a 20-year-old male who was clinically diagnosed with APS-1 at the age of 15.

JAB1 promotes palmitate-induced insulin resistance via ERK pathway in hepatocytes.

Insulin resistance (IR) is the primary pathological mechanism underlying Type 2 diabetes mellitus (T2DM). Many researches have reported the relationship between chronic inflammation and IR, while the extracellular signal-regulated kinase 1/2 (ERK1/2) pathway is rapidly activated in inflammatory conditions. However, the functional role of ERK1/2 in IR remains to be identified.

Serum adropin levels are decreased in Chinese type 2 diabetic patients and negatively correlated with body mass index.

Adropin has been identified as potent regulatory hormone implicated in insulin sensitivity and the maintenance of energy homeostasis. The aim of current study was to investigate serum adropin concentrations of type 2 diabetes mellitus (T2DM) patients in the fasting status, especially those overweight/obese and evaluate the relationships between adropin levels and metabolic parameters. A total of 116 T2DM patients and 60 controls with normal glucose tolerance (NGT) were recruited to the study.