Publications by authors named "Xinglun Lu"
Article Synopsis
- Carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a serious global health threat, with limited treatment options available, highlighting the need for new alternatives like bacteriophages.
- Researchers have isolated a novel phage, vB_KpnP_23, from hospital sewage that effectively targets and destroys various CRKP strains, particularly those linked to serious infections.
- The combination of vB_KpnP_23 with certain antibiotics shows a significant synergistic effect, potentially reducing necessary drug dosages and enhancing treatment outcomes against antibiotic resistance.
Article Synopsis
- Scientists studied a type of bacteria called CR-hvKP that is resistant to antibiotics and can make people very sick.
- They found five different strains of this bacteria in a hospital in China and tested how they were resistant and how dangerous they could be.
- The research showed that these bacteria have special genes that help them resist treatments and can share these genes with other bacteria, which could make fighting infections even harder.
Co-transfer of IncFII/IncFIB and IncFII plasmids mediated by IS26 facilitates the transmission of mcr-8.1 and tmexCD1-toprJ1.
Ann Clin Microbiol Antimicrob
February 2024
Article Synopsis
- This study focused on the genomic characteristics of two clinical strains of Klebsiella pneumoniae, both of which are resistant to key antibiotics, colistin and tigecycline, and carry specific resistance genes (mcr-8.1 and tmexCD1-toprJ1).
- The strains, isolated from different patients, were analyzed using various methods like antimicrobial susceptibility testing, whole-genome sequencing, and bioinformatics to understand their resistance mechanisms and plasmid structures.
- Results showed that the strains displayed extensive multidrug resistance, with distinct plasmid structures facilitating gene transfer, indicating a concerning trend of antibiotic resistance driven by genetic rearrangements.
Objectives: Urinary tract infection (UTI) is one of the most common extraintestinal infections, and uropathogenic Escherichia coli (UPEC) is the main cause of UTIs. However, the ability to treat UTI has been compromised by the increase in antimicrobial resistance, especially carbapenem resistance. Here, we aimed to characterize the antimicrobial resistance and molecular epidemiology of carbapenem-resistant UPEC isolated in Shandong, China.
View Article and Find Full Text PDFhas recently gained increased importance owing to the New Delhi metallo-β-lactamase (NDM) and other β-lactamases produced by its clinical isolates. These enzymes reduce the efficiency of antimicrobial therapy. Herein, we reported the findings of whole-genome sequence analysis and a comprehensive pan-genome analysis performed on a multidrug-resistant .
View Article and Find Full Text PDFTreatment strategies of infection by carbapenem-resistant (CRKP) are limited. Fosfomycin, a broad-spectrum antibiotic, has attracted renewed interest in combination therapy to fight infections. However, reports on fosfomycin-resistant are increasing.
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