Publications by authors named "Xingling Tan"
Severe infection is a critical health threat to humans, and antibiotic treatment is one of the main therapeutic approaches. Nevertheless, the efficacy of various antibiotic injection regimens in severe infection patients remains uncertain. This study aimed to comprehensively evaluate the impact of various antibiotic injection strategies on patients with severe infection through a meta-analysis.
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- RNA modifications like N6-methyladenosine, N1-methyladenosine, and 5-methylcytosine are crucial in cardiovascular disease, yet their role in dilated cardiomyopathy (DCM) is still unclear.
- Three machine learning models were utilized to identify key RNA modification regulators (RMRs) linked to DCM, leading to the development of a risk prediction model that showed high accuracy and sensitivity.
- IGFBP2 emerged as a significant biomarker for left ventricular dysfunction in DCM, showing strong correlations with clinical traits and potential as a therapeutic target in future treatments.
Article Synopsis
- Dilated cardiomyopathy (DCM) is a serious heart condition with high mortality, and there’s a need to identify biomarkers and treatment options due to insufficient molecular understanding.
- Using methods like Weighted Gene Co-expression Network Analysis, researchers identified eight key genes linked to DCM and confirmed their expression levels in a mouse model, revealing five that were significantly upregulated.
- These identified genes not only provided good accuracy in predicting DCM risk through constructed models but also showed potential as biomarkers for diagnosis and treatment, with differences noted in immune cell presence between DCM and normal samples.