Publications by authors named "Xingliang Zhou"

Background: ECMO (extracorporeal membrane oxygenation) is an effective technique for providing short-term mechanical support to the heart, lungs, or both. During ECMO treatment, the inflammatory response, particularly involving cytokines, plays a crucial role in pathophysiology. However, the potential effects of cytokines on patients receiving ECMO are not comprehensively understood.

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Hypothermia is commonly used to protect donor hearts during transplantation. However, patients transplanted with aged donor hearts still have severe myocardial injury and decreased survival rates, but the underlying mechanism remains unknown. Because aged hearts are not considered suitable for donation, the number of patients awaiting heart transplants is increasing.

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Background And Aims: Patients with acute myeloid leukaemia (AML) suffer from severe myocardial injury during daunorubicin (DNR)-based chemotherapy and are at high risk of cardiac mortality. The crosstalk between tumour cells and cardiomyocytes might play an important role in chemotherapy-related cardiotoxicity, but this has yet to be demonstrated. This study aimed to identify its underlying mechanism and explore potential therapeutic targets.

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  • The article with DOI: 10.3389/fimmu.2023.1153573 has been corrected for accuracy.
  • The correction addresses specific errors or clarifications needed in the original publication.
  • This ensures that readers have the most reliable and up-to-date information from the article.
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Objective: The objective of this study was to assess the effectiveness of fecal collection devices in preventing incontinence-associated dermatitis (IAD) and reducing skin care time in ICU patients with fecal incontinence undergoing Extracorporeal Membrane Oxygenation (ECMO).

Methods: A nonrandomized comparison cohort (quasi-experimental) study with pre-post comparison was carried out in a general intensive care unit. 85 bedridden patients receiving ECMO with fecal incontinence (FI) in a general intensive care unit between June 2017 and May 2022 participated in the study and separated into two groups according to the fecal collection device they received.

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Background: Nearly 20% Patients with cyanotic congenital heart disease (CCHD) are not able to receive surgery. These patients experience a decline in cardiac function as they age, which has been demonstrated to be associated with changes in energy metabolism in cardiomyocytes. Trimetazidine (TMZ), a metabolic regulator, is supposed to alleviate such maladaptation and reserve cardiac function in CCHD patients.

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Transfer of autologous tumor infiltrating lymphocytes (TIL) to patients with refractory melanoma has shown clinical efficacy in a number of trials. However, extending the clinical benefit to patients with other cancers poses a challenge. Inefficient costimulation in the tumor microenvironment can lead to T cell anergy and exhaustion resulting in poor anti-tumor activity.

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  • Inflammation plays a key role in the development of pulmonary arterial hypertension (PAH), with immune cell activity being regulated by chemokines and their receptors; this study focuses on identifying crucial chemokines involved in PAH progression through transcriptomic analysis.
  • Researchers analyzed gene expression data from PAH patients compared to controls, using methods like gene set enrichment analysis (GSEA) and weighted correlation network analysis (WGCNA) to discover diagnostic markers and understand immune cell involvement.
  • The study found that ACKR4, an atypical chemokine receptor, was downregulated in PAH lung tissues, correlating with reduced immune cell activation; this suggests that ACKR4 may play a protective
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Chemically modified mRNA (modRNA) has proven to be a versatile tool for the treatment of various cancers and infectious diseases due to recent technological advancements. However, a safe and effective delivery system to overcome the complex extracellular and intracellular barriers is required in order to achieve higher therapeutic efficacy and broaden clinical applications. Here, we explored All-Fect and Leu-Fect C as novel transfection reagents derived from lipopolymers, which demonstrated excellent biocompatibility, efficient delivery capabilities, and a robust ability to escape the lysosomes.

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Introduction: When starting continuous renal replacement therapy (CRRT), vasopressor-dependent patients are at risk of hemodynamic instability. Thus far, only a few studies have analyzed the impact of CRRT circuit replacement for vasopressor-dependent patients. Hence, we compared the effect of double-machine replacement protocol (DMRP) with single-machine replacement protocol (SMRP) for CRRT circuit replacement in vasopressor-dependent patients.

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Cardiovascular diseases have become a major threat to human health. The adhesion formation is an inevitable pathophysiological event after cardiac surgery. We have previously shown that gelatin/polycaprolactone (GT/PCL, mass ratio 50:50) electrospun nanofibrous membranes have high potential in preventing postoperative cardiac adhesion, but the effect of GT:PCL composition on anti-adhesion efficacy was not investigated.

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BACKGROUND Liver failure after resection for liver cancer is associated with increased patient mortality. This study aimed to investigate the mechanism of the protective effects of resveratrol, a natural plant-derived compound, on liver injury in a rat model of partial hepatectomy. MATERIAL AND METHODS Adult male Sprague-Dawley (SD) rats (n=60) were divided into the sham group (n=20), the liver resection group (n=20), and the liver resection plus resveratrol-treated group (n=20).

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  • Neural stem cells (NSCs) originate early in embryonic development and are initially biased towards becoming neurons, but maintaining them long-term in lab conditions is difficult.
  • This study outlines a new culture method that successfully allows for the long-term preservation and clonal propagation of Sox1-positive NSCs, which can efficiently differentiate into specific types of neurons from the anterior and midbrain regions.
  • The research also shows that these early-stage NSCs can be transitioned to late-stage NSCs capable of developing into astrocytes and oligodendrocytes, suggesting significant potential for cell-based therapies for nervous system disorders.
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In many cancers, combination therapy regimens are successfully improving response and survival rates, but the challenges of toxicity remain. GRP78, the master regulator of the unfolded protein response, is emerging as a target that is upregulated in tumors, specifically following treatment, and one that impacts tumor cell survival and disease recurrence. Here, we show IT-139, an antitumor small molecule inhibitor, suppresses induction of GRP78 from different types of endoplasmic reticulum (ER) stress in a variety of cancer cell lines, including those that have acquired therapeutic resistance, but not in the non-cancer cells being tested.

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Background: It is widely accepted that cognitive processes, such as learning and memory, are affected in depression, but the molecular mechanisms underlying the interactions of these 2 disorders are not clearly understood. Recently, glycogen synthase kinase-3 beta (GSK-3β)/β-catenin signaling was shown to play an important role in the regulation of learning and memory.

Methods: The present study used a rat model of depression, chronic unpredictable stress, to determine whether hippocampal GSK-3β/β-catenin signaling was involved in learning and memory alterations.

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Purpose: The purpose of this study was to compare the effect of a 1-piece drainable pouch to standard care on occurrences of incontinence-associated dermatitis (IAD) in intensive care unit (ICU) patients with fecal incontinence (FI).

Design: Nonrandomized comparison cohort (quasi-experimental) study.

Methods: Sixty-two bedridden patients with FI and indwelling urinary catheters in the ICU of the Shunde Hospital, Southern Medical University, Foshan, China, participated in the study.

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  • Mouse epiblast stem cells (mEpiSCs) and human embryonic stem cells (hESCs) rely on the cytoplasmic stability of β-catenin to maintain self-renewal, though the specific mechanisms are not fully understood.
  • The study reveals that cytoplasmic β-catenin retains TAZ, a key regulator in the Hippo pathway, in the cytoplasm, which promotes self-renewal for mEpiSCs in the absence of β-catenin in the nucleus.
  • While TAZ is not needed for the self-renewal of naive mouse embryonic stem cells (mESCs), it is essential for their conversion to mEpiSCs, highlighting that
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Purpose: This study aimed to assess a new approach combining venoarterial (VA) extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT) in adults, while monitoring CRRT circuit pressures.

Methods: The inlet and outlet of the CRRT circuit were connected to preoxygenator port and postoxygenator port, respectively. Then, complications and CRRT circuit pressures were evaluated.

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  • Dual inhibition of GSK3 and MEK is crucial for maintaining mouse and rat embryonic stem cell (ESC) self-renewal.
  • Inhibition of GSK3 helps promote self-renewal by reducing TCF3's repression on the pluripotency network, while MEK's role in this process is less understood.
  • Our findings reveal that inhibiting MEK decreases LEF1 expression, which is linked to endoderm specification, suggesting that avoiding differentiation signals is key to keeping ESCs in their undifferentiated state.
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  • - The study examines the role of heat shock transcription factor 1 (HSF1) and its interaction with β-catenin in regulating the NLRP3 inflammasome during liver injury caused by ischemia/reperfusion (I/R).
  • - Mice lacking myeloid HSF1 showed increased liver damage and inflammation, linked to heightened levels of XBP1 and NLRP3, indicating that HSF1 typically acts to protect against such injuries by modulating immune responses.
  • - The findings suggest that HSF1 promotes β-catenin activation, which inhibits the XBP1 pathway; this interplay is crucial for controlling NLRP3 activation and overall inflammatory responses in the liver.
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  • Chromosomal translocation is a frequent chromosomal abnormality linked to genetic disorders, infertility, and cancer, but lack of research models has limited progress in understanding and treating these issues.
  • Researchers have successfully used CRISPR/Cas9 technology to create specific chromosomal translocations in mouse embryonic stem cells (mESCs).
  • These modified mESCs can be expanded into stable cell lines and used to generate chimeric mice, providing new models to study translocation effects and develop potential therapies.
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Activation of Wnt/β-catenin signaling can induce both self-renewal and differentiation in naive pluripotent embryonic stem cells (ESCs). To gain insights into the mechanism by which Wnt/β-catenin regulates ESC fate, we screened and characterized its downstream targets. Here, we show that the self-renewal-promoting effect of Wnt/β-catenin signaling is mainly mediated by two of its downstream targets, Klf2 and Tfcp2l1.

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  • - Pluripotent stem cells are valuable for research and have been successfully maintained in the lab primarily in mice and rats.
  • - In-depth studies on embryonic development and existing stem cells have revealed mechanisms that support both naïve and primed pluripotent states.
  • - Understanding these mechanisms across species can inform future research in stem cell biology and enhance developments in regenerative medicine.
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  • Embryonic stem cells (ESCs) can grow indefinitely in the lab and have the ability to become any cell type, making them valuable for tissue repair and disease modeling.
  • * Understanding how ESCs decide to either keep growing or become specialized cells is essential for maximizing their potential.
  • * The review explores different signaling pathways that influence these decisions in mouse, rat, and human ESCs, focusing on how they fit into ESC-specific regulatory networks.
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Wnt/β-catenin signalling has a variety of roles in regulating stem cell fates. Its specific role in mouse epiblast stem cell self-renewal, however, remains poorly understood. Here we show that Wnt/β-catenin functions in both self-renewal and differentiation in mouse epiblast stem cells.

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