Publications by authors named "Xinglan Huang"
Article Synopsis
- The research explored how Tubastatin-A, a glucocorticoid receptor inhibitor, and MitoQ, an antioxidant, can reduce macrophage cell death caused by dexamethasone (DEX).
- The study treated macrophage cells with DEX along with Tubastatin-A or MitoQ, measuring various mitochondrial function indicators, including reactive oxygen species levels and apoptosis.
- Results showed DEX increased harmful mitochondrial processes that led to cell death, while both Tubastatin-A and MitoQ effectively reduced these negative effects and improved macrophage survival, suggesting potential clinical benefits.
Microglia are resident macrophages within the central nervous system, serving as the first responders to neuroinflammation. Glucocorticoids (GCs) may cause damage to brain tissue, but the specific mechanism remains unclear. This study was divided into two parts: a glucocorticoid receptor (GR) mitochondrial translocation intervention experiment and a mitochondrial oxidative stress inhibition experiment.
View Article and Find Full Text PDFObjectives: This study aims to investigate the expression patterns of mitochondrially encoded cytochrome c oxidase 1 (MT-CO1) in different organs and tissues of mice aged six and 18 weeks.
Materials And Methods: Six-week-old female mice (n=10) were considered young lupus model mice, and 18-week-old mice (n=10) were considered old lupus model mice. Additionally, six-week-old (n=10) and 39-week-old (n=10) female Balb/c mice were used as the young and old controls, respectively.
Objectives: We sought to analyse the expression characteristics of cytochrome C oxidase subunit I in mitochondrial of MRL/lpr lupus mice.
Methods: The whole blood of MRL/lpr lupus mice was detected for whole mitochondrial genome sequencing performed by Illumina HiSeq PE150 instrument, compared with house mouse (NC_005089.1) and screened for the maximum difference gene, MT-CO1.
Objective: To analyse the gastrointestinal manifestation of Henoch-Schonlein purpura (HSP) in adult patients, including clinical and endoscopic features.
Material And Methods: Patients with a final diagnosis of HSP admitted from January 1995 to January 2006 were included. Their medical records, including clinical presentation, laboratory data, endoscopy and pathology reports, were reviewed retrospectively.
[Study on the mechanism by which Rhubarb protects the mucosal barrier of intestine of mouse].
Sichuan Da Xue Xue Bao Yi Xue Ban
March 2005
Objective: To observe the influence of Rhubarb on the the excretion of Type II PLA2 and lysozyme of small intestine of mouse.
Methods: Forty ICR mice were randomized to two groups. In the experiment group, the mice were gavaged with 0.
[Effect of somatostatin on modulation of IL-10 and TGF-beta 1 during acute pancreatitis].
Sichuan Da Xue Xue Bao Yi Xue Ban
April 2003
Objective: To observe the effect of somatostatin on modulation of IL-10 and TGF-beta 1 in acute pancreatitis and investigate the mechanism.
Methods: SD male rats were divided into 3 groups: Group 1, the normal rats as control (n = 6); Group 2, the rats with acute pancreatitis induced by ductual injection with 5% sodium cholate sulfur at the volume of 0.6 ml/kg without any other treatment (n = 8); Group 3, after pancreatitis were induced, the rats were injected hypodermically with somatostatin 3 micrograms/(kg.
[The alteration of inflammatory cytokine during acute pancreatitis].
Hua Xi Yi Ke Da Xue Xue Bao
April 2002
Objective: To observe the alteration of both inflammatory and anti-inflammatory cytokines during acute pancreatitis, and to investigate the effect of somatostatin on modulation of inflammatory and anti-inflammatory cytokines in experimental acute pancreatitis.
Methods: SD male rats were divided into 3 groups: group 1. the normal rats as control (n = 6); group 2, the rats with acute pancreatitis induced by transabdominal injection of 5% sodium cholate sulfur (at the volume of 1.