Four-Dimensional Label-Free Quantitative Proteomics of Ginsenoside Rg Ameliorated Scopolamine-Induced Memory Impairment in Mice through the Lysosomal Pathway.

Alzheimer's disease (AD) is a neurodegenerative disease. Ginsenoside Rg has shown potential in treating AD, but the underlying protein regulatory mechanisms associated with ginsenoside Rg treatment for AD remain unclear. This study utilized scopolamine to induce memory impairment in mice, and proteomics methods were employed to investigate the potential molecular mechanism of ginsenoside Rg in treating AD model mice.