Nonreciprocal field transformation with active acoustic metasurfaces.

Field transformation, as an extension of the transformation optics, provides a unique means for nonreciprocal wave manipulation, while the experimental realization remains a substantial challenge as it requires stringent material parameters of the metamaterials, e.g., purely nonreciprocal bianisotropic parameters.

Designing plasmonic exceptional points by transformation optics.

Exceptional points (EPs) have been shown to be useful in bringing about sensitive optical properties based on non-Hermitian physics. For example, they have been applied in plasmonics to realize nano-sensing with extreme sensitivity. While the exceptional points are conventionally constructed by considering parity-time symmetric or anti-parity-time symmetric media, we theoretically demonstrate the possibility of generating a series of non-Hermitian systems by transforming a seed system with conventional parity-time symmetry within the transformation optics framework.

Quercetin Attenuates Ethanol-Induced Iron Uptake and Myocardial Injury by Regulating the Angiotensin II-L-Type Calcium Channel.

Scope: Increased iron deposition in the myocardium in alcoholics may lead to increased risk of cardiac dysfunction. Quercetin has been demonstrated to quench production of intracellular free iron-induced -OH, but the effect of quercetin in ethanol-induced cardiac damage remains unclear. This study aims to explore whether quercetin attenuates ethanol-induced iron uptake and myocardial injury by regulating angiotensin II-L-type voltage-dependent Ca2+ channel (Ang II-LTCC).

Neuroprotective effects of a standardized flavonoid extract from Diospyros kaki leaves.

Ethnopharmacological Relevance: Flavonoids, extracted from the leaves of Diospyros kaki, are the main therapeutic components of NaoXingQing (NXQ), a potent and patented Chinese herbal remedy widely used in China for the treatment of apoplexy syndrome.

Aim Of The Study: To investigate the neuroprotective effects of FLDK-P70, a standardized flavonoid extract, using in vivo rat models of both focal ischemia/reperfusion (I/R) injury induced by middle cerebral artery occlusion (MCAO) and on transient global brain ischemia induced by four-vessel occlusion (4-VO). We also aim to examine the effects of FLDK-P70 on glutamate-induced cell injury of hippocampal neurons as well as on hypoxia-induced injury of cortical neurons in primary cell culture.

Aging changes of the angioarchitecture and arterial morphology of the spinal cord in rats.

Background: It is well known that vascular myelopathy increases with age, however, there are no systematic reports on the quantitative capillary density in the spinal cord and no reports concerning the age-related changes of vascularity and capillary density of the spinal cord.

Objective: Age-related changes of vascularity and capillary density of the spinal cord and the morphology of the ventral spinal artery were observed and measured so as to provide reference to study the microcirculation of the spinal cord.

Methods: Three different age groups of Wistar rats (1-2, 6-7 and >22 months old) were studied by ink-gelatin injection, corrosion casts, biological stereological technique, image analysis and transmission electron microscope.

Low shear stress regulates monocyte adhesion to oxidized lipid-induced endothelial cells via an IkappaBalpha dependent pathway.

In regions of a vessel that experience low shear stress and reversing flow patterns, early features in the pathogenesis of atherosclerosis include the accumulation of oxidized LDL (OxLDL) and adhesion of monocytes to endothelial cells (EC). Here we investigated the hypothesis that low shear stress (2 dyn/cm2) and OxLDL are synergistic for enhanced expression of vascular cell adhesion molecule (VCAM-1) and human aortic endothelial cell (HAEC)-monocyte adhesion. This study shows low shear stress can significantly reduce IkappaBalpha levels, activate NF-kappaB, increase the expression of VCAM-1 in HAEC and binding of monocytes.

[Overexpression of TGF beta 1 increases elastin expression and adhesion of smooth muscle cells].

This study was conducted to examine the effectiveness of a gene transfer of human TGF beta 1 gene into smooth muscle cells and whether the TGF beta 1 can increase elastin expression of smooth muscle cells. With the help of DOTAP, smooth muscle cells were transfected with pMAMneoTGF beta 1. The positive cell clones were selected with G418.