Publications by authors named "Xinghao Guo"
Article Synopsis
- Migraine, particularly chronic migraine (CM), is a complex neurological disorder with poorly understood causes, involving activation of specific brain regions like the insula and amygdala in response to pain.
- The study used nitroglycerin (NTG) to create a mouse model of chronic migraine and investigated the effects of a treatment called Olcegepant (OLC) on pain sensitivity and brain activity.
- Results indicated that OLC improved pain thresholds and reduced anxiety-like behaviors in the mice, with whole-brain imaging revealing significant activation in areas like the isocortex, somatomotor, and somatosensory regions, suggesting these as potential targets for future migraine treatments.
Background: Energy metabolism disorders and neurogenic inflammation play important roles in the central sensitization to chronic migraine (CM). AMP-activated protein kinase (AMPK) is an intracellular energy sensor, and its activation regulates inflammation and reduces neuropathic pain. However, studies on the involvement of AMPK in the regulation of CM are currently lacking.
View Article and Find Full Text PDFWith the continuous development of science and engineering technology, our society has entered the era of the mobile Internet of Things (MIoT). MIoT refers to the combination of advanced manufacturing technologies with the Internet of Things (IoT) to create a flexible digital manufacturing ecosystem. The wireless communication technology in the Internet of Things is a bridge between mobile devices.
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