Publications by authors named "Xinghan Zeng"
Unlabelled: Patients with myeloid neoplasms with loss-of-function mutations and erythroid differentiation have poor outcomes, and a better understanding of disease biology is required. Upregulation of interferon-γ (IFN-γ) signaling has been associated with acute myeloid leukemia (AML) progression and chemotherapy resistance, but its drivers remain unclear. In this study, we found that the surface receptor C-C motif chemokine receptor-like 2 (CCRL2) is overexpressed in AML with erythroid differentiation and mutations compared to other AML subtypes and healthy hematopoietic cells.
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- The study investigated the links between immune-mediated diseases (IMDs) and the risk of developing human papillomavirus (HPV)-associated diseases using data from the UK Biobank, encompassing over 500,000 participants aged 40-69.
- It found that individuals with IMDs had a significantly higher incidence of HPV-related conditions, with notable findings for specific IMDs such as asthma in women and chronic nephritic syndrome in men.
- The research highlights important differences in the risk of HPV diseases based on whether the outcomes were benign or malignant, as well as the anatomical sites affected.