Novel methyltransferase G9a inhibitor induces ferroptosis in multiple myeloma through Nrf2/HO-1 pathway.

Multiple myeloma (MM) is a common malignant hematologic neoplasm, and the involvement of epigenetic modifications in its development and drug resistance has received widespread attention. Ferroptosis, a new ferroptosis-dependent programmed death mode, is closely associated with the development of MM. The novel methyltransferase inhibitor DCG066 has higher cell activity, but its mechanism of action in MM has not been clarified.

B7-H7: A potential target for cancer immunotherapy.

Cancer immunotherapy enhances the body's immunity against tumors by mitigating immune escape. Compared with traditional chemotherapy, immunotherapy has the advantages of fewer drugs, a wider range of action and fewer side effects. B7-H7 (also known as HHLA2, B7y) is a member of the B7 family of costimulatory molecules that was discovered more than 20 years ago.

Tumor-associated macrophages in lymphoma: From mechanisms to therapy.

Lymphoma is a common hematologic malignant tumor that originates from lymph nodes or other lymphoid tissues. The tumor microenvironment (TME) plays an indispensable role in tumorigenesis, tumor development, metastasis, relapse, and drug resistance. Macrophages, which are considered as critical immune cells in the TME, influence the development of tumors.