Chemical composition and antioxidant activity of petroleum ether fraction of .

The presented study examines the chemical composition and antioxidant activity of the petroleum ether fraction of (PEF-RO), which was obtained via 75 % ethanol extraction followed by petroleum ether extraction. The obtained fractions were analyzed by gas chromatography-mass spectrometry (GC-MS). The antioxidant activity of PEF-RO was investigated using various assays, including 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonate (ABTS) free radical scavenging, and ferric reducing antioxidant power (FRAP) method.

Ligand Evolution in the Photoactivatable Platinum(IV) Anticancer Prodrugs.

Photoactivatable Pt(IV) anticancer prodrugs with the structure of [Pt(N)(N)(L)(L)(A)(A)], where N and N are non-leaving nitrogen donor ligands, L and L are leaving ligands, and A and A are axial ligands, have attracted increasing attention due to their promising photo-cytotoxicity even to cisplatin-resistant cancer cells. These photochemotherapeutic prodrugs have high dark-stability under physiological conditions, while they can be activated by visible light restrained at the disease areas, as a consequence showing higher spatial and temporal controllability and much more safety than conventional chemotherapy. The coordinated ligands to the Pt center have been proved to be pivotal in determining the function and activity of the photoactivatable Pt(IV) prodrugs.