Publications by authors named "Xingfan Chen"

In three-dimensional (3D) measurement, the motion of objects inevitably introduces errors, posing significant challenges to high-precision 3D reconstruction. Most existing algorithms for compensating motion-induced phase errors are tailored for object motion along the camera's principal axis (Z direction), limiting their applicability in real-world scenarios where objects often experience complex combined motions in the X/Y and Z directions. To address these challenges, we propose a universal motion error compensation algorithm that effectively corrects both pixel mismatch and phase-shift errors, ensuring accurate 3D measurements under dynamic conditions.

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As one of the directions of optical levitation technology, the mass measurement of micro-nano particles has always been a research hotspot in extremely weak mechanical measurements. When nanoscale particles are trapped in an optical trap, parameters such as density, diameter, and shape are unknown. Here we propose what we believe to be a new method to measure mass by fitting particle motion information to the Maxwell speed distribution law, with an accuracy better than 7% at 10 mbar.

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Myasthenia gravis is an autoimmune disease characterized by pathogenic antibodies that target structures of the neuromuscular junction. However, some patients also experience autonomic dysfunction, anxiety, depression, and other neurological symptoms, suggesting the complex nature of the neurological manifestations. With the aim of explaining the symptoms related to the central nervous system, we utilized a rat model to investigate the impact of dopamine signaling in the central nervous and peripheral circulation.

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For an interferometric fiber-optic gyroscope (IFOG), the angle random walk, which represents the sensitivity of rotation detection, is mainly limited by the relative intensity noise (RIN) of a broadband source. Using a single-mode fiber ring resonator (SM-FRR) to filter the spectrum of a broadband light source is a common strategy for reducing the RIN at the proper IFOG frequency. However, this method depends on the polarization cross-coupling within the SM-FRR.

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Myasthenia gravis (MG) is characterized by fatigable skeletal muscle weakness with a fluctuating and unpredictable disease course and is caused by circulating autoantibodies and pathological T helper cells. Regulation of B-cell function and the T-cell network may be a potential therapeutic strategy for MG. MicroRNAs (miRNAs) have emerged as potential biomarkers in immune disorders due to their critical roles in various immune cells and multiple inflammatory diseases.

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Levitated micro-resonators in vacuums have attracted widespread attention due to their application potential in precision force sensing, acceleration sensing, mass measurement and gravitational wave sensing. The optically levitated microsphere in a counter-propagating dual-beam optical trap has been of particular interest because of its large measurement range and flexible manipulation. In this system, laser intensity fluctuation directly influences the trap stability and measurement sensitivity, which makes it a crucial factor in improving trapping performance.

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Article Synopsis
  • Optical trapping of nanoparticles in vacuum is important for precise measurements and fundamental physics, but determining the size and number of particles is challenging without a vacuum environment.
  • The study presents a new method for estimating nanoparticle size using scattering light from particles in an optical tweezer system, demonstrating experimental success in non-vacuum conditions.
  • This method shows strong agreement with existing theories and can preselect single particles from a mixed sample, making it useful for various types of nanoparticles and potentially aiding in the discovery of new scattering effects.
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The focusing properties of elegant third-order Hermite-Gaussian beams (THGBs) and the radiation forces exerted on dielectric spherical particles produced by such beams in the Rayleigh scattering regime have been theoretically studied. Numerical results indicate that the elegant THGBs can be used to simultaneously trap and manipulate nanosized dielectric spheres with refractive indexes lower than the surrounding medium at the focus and those with refractive indexes larger than the surrounding medium in the focal vicinity. Furthermore, by changing the radius of the beam waist, the transverse trapping range and stiffness at the focal plane can be changed.

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We presented faster and more accurate simulations and experiments describing the revolution of a suspended particle in optical tweezers under a low pressure. Instead of the state-of-the-art offline method of pinhole alignment, we proposed an in situ method of revolution suppression by adjusting the laser beam while observing the power spectral density and time-domain plot of the particle centroid displacement. The experimental results under different air pressures show that our method is more effective at low pressures.

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This study investigates the propagation properties and radiation forces on Rayleigh dielectric particles produced by novel sine-modulated Gaussian beams (SMGBs) because of the unique focusing properties of four independent light intensity distribution centers and possessing many deep potential wells in the output plane of the target laser. The described beams can concurrently capture and manipulate multiple Rayleigh dielectric spheres with high refractive indices without disturbing each other at the focus plane. Spheres with a low refractive index can be guided or confined in the focus but cannot be stably trapped in this single beam trap.

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Background: Venous malformations (VM) are common vascular malformations. Percutaneous injection of sclerosants into the lesion has become mainstream therapy. The most commonly used sclerosants are ethanol, polidocanol, bleomycin, and the like.

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As a kind of ultra-sensitive acceleration sensing platform, optical tweezers show a minimum measurable value inversely proportional to the square of the diameter of the levitated spherical particle. However, with increasing diameter, the coupling of the displacement measurement between the axes becomes noticeable. This paper analyzes the source of coupling in a forward-scattering far-field detection regime and proposes a novel method of suppression.

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To investigate the efficacy and safety of combined therapy with adrenergic beta-antagonist and lasers in infantile hemangiomas (IH). A search of Pubmed, Cochrane, Embase, Wanfang Date, CNKI (China National Knowledge Infrastructure) and CBM (China Biology Medicine) databases was conducted to identify studies that examined response to combined therapy with adrenergic beta-antagonist and laser in IH patients. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) in random-effects or fixed-effects models were calculated with Review Manger 5.

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To explore the role of progesterone in the pathogenesis and development of hemangioma in nude mice.
 Methods: The hemangioma model was established. Progesterone was injected intramuscularly at different doses (0.

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High precision fiber-optic gyroscopes (FOGs) interrogated with broadband light have angular random walk (ARW) limited by the source relative intensity noise (RIN). A passive fiber ring resonator (passive FRR) reduces the RIN and improves the ARW, but the low power transmission results in a low signal-to-noise ratio at the detection. For a great ARW improvement, the fiber ring resonator should have not only a great RIN reduction but also a large power transmission.

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The eigen frequency is a key parameter of a fiber optic gyroscope (FOG). We present an online eigen frequency tracking method for FOG technology based on the staircase waveform and a four-step frequency perturbation. Results show that the measurement accuracy of the eigen frequency does not exceed 1.

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A method of improving the angular random walk (ARW) of a fiber optic gyroscope (FOG) using a fiber ring resonator (FRR) to reduce the relative intensity noise (RIN) is demonstrated. An FRR reduces the RIN near the proper frequency and improves the ARW. The analytical forms for the RIN transfer function and the power transmission of the FRR are derived when the free spectral range of the FRR is much narrower than the source bandwidth.

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