Organocatalytic Enantioselective Synthesis of Inherently Chiral Calix[4]arenes.

Inherently chiral calix[4]arenes are an excellent structural scaffold for enantioselective synthesis, chiral recognition, sensing, and circularly polarized luminescence. However, their catalytic enantioselective synthesis remains challenging. Herein, we report an efficient synthesis of inherently chiral calix[4]arene derivatives via cascade enantioselective cyclization and oxidation reactions.

Light-Responsive Supramolecular Liquid-Crystalline Metallacycle for Orthogonal Multimode Photopatterning.

The development of multimode photopatterning systems based on supramolecular coordination complexes (SCCs) is considerably attractive in supramolecular chemistry and materials science, because SCCs can serve as promising platforms for the incorporation of multiple functional building blocks. Herein, we report a light-responsive liquid-crystalline metallacycle that is constructed by coordination-driven self-assembly. By exploiting its fascinating liquid crystal features, bright emission properties, and facile photocyclization capability, a unique system with spatially-controlled fluorescence-resonance energy transfer (FRET) is built through the introduction of a photochromic spiropyran derivative, which led to the realization of the first example of a liquid-crystalline metallacycle for orthogonal photopatterning in three-modes, namely holography, fluorescence, and photochromism.

Diagnostic Performance and Accuracy of Strain Elastography for BI-RADS Category 4 Lesions among Asian Females.

This work aimed to assess the diagnostic performance of strain elastography (elasticity score) and its accuracy for breast BI-RADS category 4 lesions. Online databases including Cochrane Library, Embase, PubMed, and Web of Science were searched for eligible articles published prior to March 10, 2022. The pooled effect indicators including sensitivity, specificity, positive and negative likelihood ratios (PLR, NLR), the area under the summary receiver operating characteristic (SROC) curve, and diagnostic odds ratio (DOR) were utilised to assess the strain elastography's performance in diagnosing BI-RADS category 4 lesions.

A supramolecular artificial light-harvesting system based on a luminescent platinum(II) metallacage.

A trigonal luminescent metallacage was constructed by the coordination-driven self-assembly of -pyridine-modified tetraphenylene ligands with organic Pt(II) acceptors, which exhibited excellent Aggregation-Induced Emission (AIE) properties. An efficient artificial light-harvesting system was successfully constructed by selecting the metallacage as the donor and the hydrophobic fluorescent dye Nile Red (NiR) as the donor molecule in a system of acetone/water (1/9, v/v), The absorption spectra of NiR and the emission spectra of the metallacage showed considerable overlap, achieving energy transfer from the metallacage to NiR.

Design of a large Stokes shift ratiometric fluorescent sensor with hypochlorite detection towards the potential application as invisible security ink.

Hypochlorite (ClO) as a well-known highly reactive oxygen species (ROS), is widely used as preservative and household disinfectant in daily life. Although many fluorescence imaging sensors for ClO have been reported, the development of ClO ratio fluorescence sensors with large Stokes shift is still quite limited. This sensor shows obvious benefits including minimizing environmental intervention and improving signal-to-noise ratio.

Dynamic Covalent Bond Cross-Linked Luminescent Silicone Elastomer with Self-Healing and Recyclable Properties.

Two aldehyde-modified tetraphenylene derivatives with different functionality are synthesized and exhibit different fluorescence properties. By incorporating tetraphenylene derivatives into polydimethylsiloxane (PDMS) networks, two elastomers are prepared through dynamic covalent cross-linking. The elastomers show excellent fluorescence properties, mechanical properties, thermal stability as well as self-healing and recycle properties.

Self-assembly of an alkynylpyrene derivative for multi-responsive fluorescence behavior and photoswitching performance.

Highly emissive fluorophores based on polyaromatic hydrocarbons with tunable emission properties and aggregated structures play a very important role in relevant functional studies. In this study, a novel alkynylpyrene derivative 1 was synthesized, which exhibits unimolecular to excimer emission in methanol with an increasing concentration accompanied by the formation of nanovesicles via the π-π stacking, hydrogen bond and hydrophobic interaction. The self-assembly behavior as well as emission properties of 1 in aprotic polar solvents (ACN, acetone, DMF and DMSO) can also be adjusted by the volume fraction of the poor solvent H2O, which can induce 1 self-assembly to excimer state and could be applied in information transfer.

Facile construction of a double network cross-linked luminescent supramolecular elastomer by hydrosilylation and pillar[5]arene host-guest recognition.

Reticulated copolymer host pillar[5]arene cross-linked with poly(dimethylsiloxane) (PDMS) was synthesized for the facile construction of a double network cross-linked elastomer upon noncovalently cross-linking with tetraphenyethylene (TPE)-based tetratopic guests through host-guest interactions. The obtained sample strips had better mechanical properties and luminescence capabilities.

Correction: The lipogenic LXR-SREBF1 signaling pathway controls cancer cell DNA repair and apoptosis and is a vulnerable point of malignant tumors for cancer therapy.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

The lipogenic LXR-SREBF1 signaling pathway controls cancer cell DNA repair and apoptosis and is a vulnerable point of malignant tumors for cancer therapy.

Cancer cells are defective in DNA repair, so they experience increased DNA strand breaks, genome instability, gene mutagenesis, and tumorigenicity; however, multiple classic DNA repair genes and pathways are strongly activated in malignant tumor cells to compensate for the DNA repair deficiency and gain an apoptosis resistance. The mechanisms underlying this phenomenon in cancer are unclear. We speculate that a key DNA repair gene or signaling pathway in cancer has not yet been recognized.

Primary anorectal malignant melanoma: A case report.

Introduction: Anorectal malignant melanoma (AMM) is a rare and aggressive malignance with poor prognosis, yet no consensus of treatment exists to date. Abdominoperineal resection surgery (APR) is the standard treatment of anorectal malignant melanoma, capable of controlling lymphatic spread and obtaining a large negative margin for local control but it can lead to complications. Wide local excision (WLE) allows for quicker recovery and has minimal impact on bowel function (i.

Turn-on fluorescence in a pyridine-decorated tetraphenylethylene: the cooperative effect of coordination-driven rigidification and silver ion induced aggregation.

A tetrapyridine-decorated tetraphenylethene (TPE) ligand 1 was designed, which, upon interacting with silver ions, displayed "turn-on" fluorescence in a dilute solution. The fluorescence enhancement can be attributed to the cooperative effect of restriction of the intramolecular rotation by metal coordination and silver ion induced aggregation. Furthermore, the fluorescence turn-on performance of AIE molecules in a dilute solution leads to tunable fluorescence properties including white-light emission by simply mixing AIE and ACQ molecules together, which might bridge the gap between the AIE and ACQ phenomena for the construction of color-tunable fluorescence systems.

Selective activation of tumor-suppressive MAPKP signaling pathway by triptonide effectively inhibits pancreatic cancer cell tumorigenicity and tumor growth.

The mitogen-activated protein kinase (MAPK, 1K) family members ERK, JNK, and p38 play a divergent role in either promoting tumorigenesis or tumor-suppression. Activation of ERK and JNK promotes tumorigenesis; whereas, escalation of p38 inhibits carcinogenesis. As these three MAPK members are controlled by the common up-stream MAPK signaling proteins which consist of MAPK kinases (2K) and MAPK kinase kinases (3K), how to selectively actuate tumor-suppressive p38, not concurrently stimulate tumorigenic ERK and JNK, in cancer cells is a challenge for cancer researchers, and a new opportunity for novel anti-cancer drug discovery.

Association between hOGG1 Polymorphisms and Pancreatic Cancer Susceptibility: A Meta-analysis.

Human 8-oxoguanine DNA glycosylase (hOGG1) plays a pivotal role in the initiating and progression of pancreatic cancer. Many studies implicated the association of hOGG1 polymorphism and pancreatic cancer susceptibility. However, the results remained inconclusive.

Stable Oxindolyl-Based Analogues of Chichibabin's and Müller's Hydrocarbons.

Chichibabin's and Müller's hydrocarbons are classical open-shell singlet diradicaloids but they are highly reactive. Herein we report the successful synthesis of their respective stable analogues, OxR-2 and OxR-3, based on the newly developed oxindolyl radical. X-ray crystallographic analysis on OxR-2 reveals a planar quinoidal backbone similar to Chichibabin's hydrocarbon, in accordance with its small diradical character (y =11.

Facile Construction of Structurally Defined Porous Membranes from Supramolecular Hexakistriphenylamine Metallacycles through Electropolymerization.

The construction of well-controlled porous materials is very challenging. Herein, we report the successful preparation of structurally defined porous membranes based on hexakistriphenylamine metallacycles through electropolymerization. The newly designed porous materials were characterized by the typical cyclic voltammograms, XPS, SEM, and TEM investigations.

Light and cucurbit[7]uril complexation dual-responsiveness of a cyanostilbene-based self-assembled system.

A cyanostilbene-based amphiphile (CS) was synthesized, which could self-assemble into non-emissive bilayer vesicles and ultra-thin ribbons. Cucurbit[7]uril (CB[7]) could form an inclusion complex with CS with a significant hypochrome effect, giving a strong blue emission from non-emissive species. CS underwent photoisomerization induced by light irradiation, which allowed the membrane contraction into smaller vesicles.

Host-Guest Interaction-Mediated Construction of Hydrogels and Nanovesicles for Drug Delivery.

Hand-in-hand or head-to-head: A novel naphthalimide derivative is successfully designed and synthesized, which can self-assemble to produce hydrogels. When injecting this compound into CB[8] solution, the nanovesicles are obtained with a narrow size distribution. The cytotoxicity assay confirms that doxorubicin-loaded nanocarriers show therapeutic effects to cancer cells.

Imaging-Guided Drug Release from Glutathione-Responsive Supramolecular Porphysome Nanovesicles.

Drug delivery systems that can be employed to load anticancer drugs and release them triggered by a specific stimulus, such as glutathione, are of great importance in cancer therapy. In this study, supramolecular porphysome nanovesicles that were self-assembled by amphiphilic porphyrin derivatives were successfully constructed, mainly driven by the π-π stacking, hydrogen bonding, and hydrophobic interactions, and were used as carriers of anticancer drugs. The nanovesicles are monodispersed in shape and uniform in size.

Hierarchical self-assembly of supramolecular hydrophobic metallacycles into ordered nanostructures.

We describe herein the hierarchical self-assembly of discrete supramolecular metallacycles into ordered fibers or spherical particles through multiple noncovalent interactions. A new series of well-defined metallacycles decorated with long alkyl chains were obtained through metal-ligand interactions, which were capable of aggregating into ordered fibroid or spherical nanostructures on the surface, mostly driven by hydrophobic interactions. In-depth studies indicated that the morphology diversity was originated from the structural information encoded in the metallacycles, including the number of alkyl chains and their spatial orientation.

Design and preparation of ethynyl-pyrene modified platinum-acetylide gelators and their application in dispersion of graphene.

A series of new ethynyl-pyrene modified platinum-acetylide gelators were prepared, some of which were found to be able to incorporate graphene into the metallogel matrix.

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses vasculogenic mimicry and proliferation of highly aggressive pancreatic cancer PaTu8988 cells.

Background: Pancreatic cancer is one of the most aggressive human malignancies with a extremely low 5-year survival rate. Hence, the search for more effective anti-pancreatic cancer agents is urgent.

Methods: PaTu8988 pancreatic cancer cells were treated with different concentrations of suberoylanilide hydroxamic acid (SAHA), cell survival, proliferation, migration and vasculogenic mimicry (VM) were analyzed.

Design and preparation of platinum-acetylide organogelators containing ethynyl-pyrene moieties as the main skeleton.

A series of new platinum-acetylide complexes containing ethynyl-pyrene moieties as the main skeleton were synthesized and characterized. The investigation of the absorption and emission spectra of these complexes revealed that the extension of the molecular size with the introduction of different numbered platinum-acetylide fragments can efficiently tune the absorption and emission bands from the UV to the longer wavelength region. Moreover, the gelation properties of these complexes were investigated by the "stable-to-inversion-of-a-test-tube" method.

Design and synthesis of branched platinum-acetylide complexes possessing a porphyrin core and their self-assembly behaviour.

A series of branched platinum-acetylide porphyrin derivatives were successfully prepared via a modified method and their self-assembly behaviour both in solution and on the surface was explored.