Publications by authors named "Xingcui Xuan"
Article Synopsis
- The study explores how disruptions in the cervicovaginal microbiome, particularly through the production of indoleacrylic acid (IAA), influence the development of gynecological cancers like endometrial cancer (EC).
- Researchers found that IAA production from certain bacterial species can promote tumor growth and affect immune cell dynamics in both patients and mouse models.
- The results indicate a connection between higher levels of IAA, increased IDO1 expression, and altered immune responses, suggesting that certain bacterial species may contribute to immune tolerance in endometrial cancer.
Diagnosis of endometrial cancer is primarily based on symptoms and imaging, with early-stage disease being difficult to diagnose. Therefore, development of potential diagnostic biomarkers is required. Metabolomics, a quantitative measurement of the dynamic metabolism in living systems, can be applied to determine metabolite profiles in different disease states.
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