Targeted lipid nanoparticles distributed in hydrogel treat osteoarthritis by modulating cholesterol metabolism and promoting endogenous cartilage regeneration.

Osteoarthritis (OA) is the most common disease in aging joints and has characteristics of cartilage destruction and inflammation. It is currently considered a metabolic disease, and the CH25H-CYP7B1-RORα axis of cholesterol metabolism in chondrocytes plays a crucial catabolic regulatory role in its pathogenesis. Targeting of this axis in chondrocytes may provide a therapeutic approach for OA treatment.

A framework for drought monitoring and assessment from a drought propagation perspective under non-stationary environments.

According to the coupled influence of climate variation and anthropogenic activities, hydro-meteorological variables are hard to keep stationary in a changing environment. Consequently, the efficacy of traditional standardized drought indices, predicated upon the assumption of stationarity, has been called into question. In China, the challenge of drought monitoring and declaration is exacerbated by the need for multiple drought indices covering meteorological, agricultural, hydrological, and groundwater aspects, often lacking real-time availability.

The Impact of Beeswax and Glycerol Monolaurate on Camellia Oil Oleogel's Formulation and Application in Food Products.

This study assessed the nutritional profile of camellia oil through its fatty acid composition, highlighting its high oleic acid content (81.4%), followed by linoleic (7.99%) and palmitic acids (7.

Comparative analysis of the biological characteristics of three CV-A10 clones adaptively cultured on Vero cells.

Coxsackievirus A10 (CV-A10) is a major pathogen that causes hand, foot, and mouth disease. There are no effective therapeutic drugs for CV-A10 infection; therefore, CV-A10 vaccines should be developed. Previously, we isolated a CV-A10 strain (N25) that can be cultured on Vero cells.

Investigating variations of precipitation concentration in the transitional zone between Qinling Mountains and Loess Plateau in China: Implications for regional impacts of AO and WPSH.

Changes in precipitation patterns greatly impact regional drought/flood risk management and utilization of water resources. The main purpose of this paper was to investigate spatio-temporal variability of precipitation concentration in the transitional zone between Qinling Mountains (QDM), Guanzhong Plain (GZP) and the Loess Plateau (LPNS) in China, using monthly-scale precipitation concentration index (PCI) and daily-scale concentration index (CI) from daily rainfall records. The Mann-Kendall method was employed to illustrate the change in trend of PCI and CI, the Kriging interpolation method was adopted to measure spatial distribution, and the Wavelet transforms were used to explore their spatio-temporal correlation with the Arctic Oscillation (AO) & Western Pacific Subtropical High (WPSH) for revealing the potential attribution of precipitation concentration variation.

Intrinsic Cross-Correlation Analysis of Hydro-Meteorological Data in the Loess Plateau, China.

The purpose of this study is to illustrate intrinsic correlations and their temporal evolution between hydro-meteorological elements by building three-element-composed system, including precipitation (P), runoff (R), air temperature (T), evaporation (pan evaporation, E), and sunshine duration (SD) in the Wuding River Basin (WRB) in Loess Plateau, China, and to provide regional experience to correlational research of global hydro-meteorological data. In analysis, detrended partial cross-correlation analysis (DPCCA) and temporal evolution of detrended partial-cross-correlation analysis (TDPCCA) were employed to demonstrate the intrinsic correlation, and detrended cross-correlation analysis (DCCA) coefficient was used as comparative method to serve for performance tests of DPCCA. In addition, a novel way was proposed to estimate the contribution of a variable to the change of correlation between other two variables, namely impact assessment of correlation change (IACC).

Improvement of Curvulamine Production by Precursors Co-addition Strategy in Liquid Culture of Marine-Derived Fungus Curvularia sp. IFB-Z10.

Curvulamine, a novel scaffold alkaloid with remarkable selective antibacterial activity, is produced by marine fungus Curvularia sp. IFB-Z10. However, its deep pharmaceutical research and application are severely restricted by the low yield, which needs to be solved urgently.

Ammonium Acetate Supplement Strategy for Enhancement of Chaetominine Production in Liquid Culture of Marine-Derived CY018.

Pharmacological research on (CHA), a marine-derived quinazolinone alkaloid with significant cytotoxic activity, is restricted by low yields and is a problem that needs to be settled urgently. In this work, the selection of additional nitrogen sources and the optimization of additional concentrations and longer fermentation times using ammonium acetate, were investigated. CHA production was optimized to 62.

Preparative separation of TL1-1 from Daldinia eschscholzii extract by macroporous resin and evaluation of its antimicrobial activities.

2,3-Dihydro-5-hydroxy-2-methylchromen-4-one (TL1-1) has already been reported to exhibit significant activities such as cytotoxicity, antifungal activity and growth inhibitory activity. In order to simply and efficiently separate TL1-1 from crude extracts of Daldinia eschscholzii on a large-preparative scale, XAD-16 resin was selected from ten types of resin based on its superior adsorption and desorption performance. Adsorption equilibrium data for this resin fitted well with pseudo-first order kinetics and the Freundlich model, which were elucidated from kinetic experiments and adsorption isotherms.

Dissolved oxygen control strategy for improvement of TL1-1 production in submerged fermentation by .

Background: 2,3-Dihydro-5-hydroxy-2-methylchromen-4-one (TL1-1) is a phenolic compound with significant anti-fungal and anti-cancer activities produced by (). However, studies have rarely been reported on the fermentation process of due to the urgent demand for its pharmaceutical researches and applications.

Results: In this work, the optimal fermentation medium for improved TL1-1 yield was first obtained in a shake flask.