Detection methods for antibiotics in wastewater: a review.

Antibiotics are widely used as fungicides because of their antibacterial and bactericidal effects. However, it is necessary to control their dosage. If the amount of antbiotics is too much, it cannot be completely metabolized and absorbed, will pollute the environment, and have a great impact on human health.

Global assessment of future sectoral water scarcity under adaptive inner-basin water allocation measures.

Water scarcity has become a major threat to sustainable development under climate change. To reduce the population exposure to water scarcity and improve universal access to safe drinking water are important targets of the Sustainable Development Goal (SDG) 6 in the near future. This study aims to examine the potential of applying adaptive inner-basin water allocation measures (AIWAM), which were not explicitly considered in previous studies, for mitigating water scarcity in the future period (2020-2050).

Global Phosphorus Losses from Croplands under Future Precipitation Scenarios.

Phosphorus (P) losses from fertilized croplands to inland water bodies cause serious environmental problems. During wet years, high precipitation disproportionately contributes to P losses. We combine simulations of a gridded crop model and outputs from a number of hydrological and climate models to assess global impacts of changes in precipitation regimes on P losses during the 21st century.

Reductions in Labor Capacity from Intensified Heat Stress in China under Future Climate Change.

Heat stress would be intensified under global warming and become a key issue of occupational health for labor force working outdoors. The changes in labor force would affect regional socioeconomic development. So far, changes in labor force due to heat stress are not well documented in China.

Multimodel uncertainty changes in simulated river flows induced by human impact parameterizations.

Human impacts increasingly affect the global hydrological cycle and indeed dominate hydrological changes in some regions. Hydrologists have sought to identify the human-impact-induced hydrological variations via parameterizing anthropogenic water uses in global hydrological models (GHMs). The consequently increased model complexity is likely to introduce additional uncertainty among GHMs.

Staurosporine scaffold-based rational discovery of the wild-type sparing reversible inhibitors of EGFR T790M gatekeeper mutant in lung cancer with analog-sensitive kinase technology.

The human epidermal growth factor receptor (EGFR) has been established as an attractive target for lung cancer therapy. However, an acquired EGFR T790M gatekeeper mutation is frequently observed in patients treated with first-line anticancer agents such as gefitinib and erlotinib to cause drug resistance, largely limiting the application of small-molecule kinase inhibitors in EGFR-targeted chemotherapy. Previously, the reversible pan-kinase inhibitor staurosporine and its several analogs such as Gö6976 and K252a have been reported to selectively inhibit the EGFR T790M mutant (EGFR ) over wild-type kinase (EGFR ), suggesting that the staurosporine scaffold is potentially to develop the wild-type sparing reversible inhibitors of EGFR .

Chemotherapy Drug Response to the L858R-induced Conformational Change of EGFR Activation Loop in Lung Cancer.

Oncogenic L858R mutation of human epidermal growth factor receptor (EGFR) confers constitutive activation to the kinase and is frequently observed in the pathological process of metastatic lung cancer. Selective inhibition of EGFR mutant over wild-type EGFR (EGFR ) has been established as an attractive target for cancer chemotherapy. Here, we performed long-term molecular dynamics (MD) simulations to reconstruct the complete dynamics trajectory of L858R-induced conformational change in EGFR activation loop (A-loop).

Risk and contributing factors of ecosystem shifts over naturally vegetated land under climate change in China.

Identifying the areas at risk of ecosystem transformation and the main contributing factors to the risk is essential to assist ecological adaptation to climate change. We assessed the risk of ecosystem shifts in China using the projections of four global gridded vegetation models (GGVMs) and an aggregate metric. The results show that half of naturally vegetated land surface could be under moderate or severe risk at the end of the 21(st) century under the middle and high emission scenarios.

Robust optimization model and algorithm for railway freight center location problem in uncertain environment.

Railway freight center location problem is an important issue in railway freight transport programming. This paper focuses on the railway freight center location problem in uncertain environment. Seeing that the expected value model ignores the negative influence of disadvantageous scenarios, a robust optimization model was proposed.

Multimodel assessment of water scarcity under climate change.

Water scarcity severely impairs food security and economic prosperity in many countries today. Expected future population changes will, in many countries as well as globally, increase the pressure on available water resources. On the supply side, renewable water resources will be affected by projected changes in precipitation patterns, temperature, and other climate variables.

Spatiotemporal analysis of ground-based woody plant leafing in response to temperature in temperate eastern China.

The analysis of woody plant leafing in response to regional-scale temperature variation using ground-based phenology is usually limited by the sparse coverage and missing data of ground observation. In this study, a station-based multispecies method was proposed to generate spatiotemporal variation of woody plant leafing date using ground observations from the Chinese Phenological Observation Network during 1974-1996. The results show that the leafing date had slightly insignificant advance (-0.

Therapeutic effect of minimally invasive decompression combined with impaction bone grafting on osteonecrosis of the femoral head.

The aim of this study was to observe the therapeutic effect of minimally invasive decompression combined with impaction bone grafting on osteonecrosis of the femoral head. A total of 67 patients underwent minimally invasive lightbulb decompression combined with impaction bone grafting. The therapeutic effect was evaluated according to Harris scores, and fluoroscopic and magnetic resolution imaging results at different time points.

Sequence analysis of the NSP2, ORF5, and ORF7 genes of 11 PRRS virus isolates from China.

During a tracing investigation of blue ear disease in China conducted from January to November 2008, 11 porcine reproductive and respiratory syndrome virus (PRRSV) isolates were collected from eight provinces including Liaoning, Jilin, Hebei, Shandong, Henan, Shanghai, Zhejiang, and Guangxi. The complete gene sequences of the NSP2, ORF5, and ORF7 genes from these 11 PRRSV isolates were amplified, cloned and detected by RT-PCR and then compared with the published sequences of other strains. The results showed that all of the isolates genotypically belonged to an American strain, but shared high homology with JXA1, the highly pathogenic strain endemic to China.

[Treatment of degenerative lumbar spondylolisthesis through posterolateral fusion and fixation with pedicle screws].

Objective: To explore internal fixation whether can improve the clinical outcomes of decompression and posterolateral fusion in patients with degenerative lumbar spondylolisthesis.

Methods: From December 1998 to December 2005, 49 patients who had degenerative lumbar spondylolisthesis underwent decompression and posterolateral fusion without (group A, 21 cases) or with (group B, 28 cases) internal fixation (CD HORIZON M8 system). There were 12 males and 37 females with a mean age of 58.

Development of reverse-transcription loop-mediated isothermal amplification for the detection of infectious bursal disease virus.

To establish a reverse-transcription loop-mediated isothermal amplification (RT-LAMP) method for rapid detection of infectious bursal disease virus (IBDV), four primers specific to six regions of the VP3 gene were designed; the VP3 region was selected because it is a conserved part of the IBDV genome. After amplification in an isothermal water bath for 70 min, samples containing IBDV generated the expected ladder-like products while other viruses generated no product. The sensitivity and specificity of the RT-LAMP assay were evaluated by comparison with reverse-transcription polymerase chain reaction (RT-PCR) and virus isolation.