Design, synthesis and evaluation of novel potent angiotensin II receptor 1 antagonists.

A series of new angiotensin II (Ang II) receptor 1 antagonists were designed, synthesized and evaluated. All compounds showed nanomolar affinities for the angiotensin II type 1 receptor in radioligand binding assays and could reduce blood pressure significantly in spontaneously hypertensive rats(SHRs). From which, compound 2b displayed higher affinity binding to angiotensin II type 1 receptor at the same order of magnitude to irbesartan with an IC50 value of 1.

High sensitivity spectroscopy of cesium Rydberg atoms using electromagnetically induced transparency.

A high sensitivity spectroscopy of Rydberg atoms is presented by using electromagnetically induced transparency (EIT) in the 6S(1/2)-6P(3/2)-n D ladder-type system of cesium vapor cell at room temperature. The EIT spectra of 40 D Rydberg state are measured and the dependences of the EIT magnitude and linewidth on the coupling laser power are investigated in detail. The Rydberg EIT linewidth is measured to be about 5.