Final analysis of a phase II trial of neoadjuvant chemoimmunotherapy for locoregionally advanced head and neck squamous cell carcinoma.

Objectives: Neoadjuvant chemoimmunotherapy has shown promising results for resectable, locoregionally advanced (LA) head and neck squamous cell carcinoma (L/A HNSCC). We published the first phase II trial of neoadjuvant camrelizumab combined with chemotherapy in resectable, L/A HNSCC, demonstrating it was safe and feasible with favorable pathological complete response (pCR). Here, we report the final analysis results for neoadjuvant chemoimmunotherapy in L/A HNSCC (minimum 2.

Neoadjuvant Chemoimmunotherapy for the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma: A Single-Arm Phase 2 Clinical Trial.

Purpose: This study aimed to assess the antitumor activity and safety of neoadjuvant chemotherapy combined with PD-1 inhibitor camrelizumab in patients with locally advanced head and neck squamous cell carcinoma (HNSCC).

Patients And Methods: In this single-center, single-arm, phase 2 trial, patients with resectable stage III-IVB HNSCC received chemotherapy [albumin-bound paclitaxel 260 mg/m2 (or docetaxel 75 mg/m2) plus cisplatin 75 mg/m2] and camrelizumab 200 mg on day 1 of each 21-day cycle for three cycles, followed by surgery, and adjuvant radiotherapy. Co-primary end points were pathological complete response (pCR) rate and safety.

Long non-coding RNA MALAT1 mediates hypoxia-induced pro-survival autophagy of endometrial stromal cells in endometriosis.

Endometriosis is a common gynecological disease characterized by diminished apoptosis, sustained ectopic survival of dysfunctional endometrial cells. Hypoxia has been implicated as a crucial microenvironmental factor that contributes to endometriosis. It has been reported that long non-coding RNA MALAT1 (lncRNA-MALAT1) highly expressed in endometriosis and up-regulated by hypoxia.

MiR-223 inhibits the proliferation, invasion and EMT of nasopharyngeal carcinoma cells by targeting SSRP1.

The aberrant expression of microRNAs (miRNAs) has been found in various types of cancer and is associated with tumorigenesis and metastasis. However, the expression and function of miR-223 in nasopharyngeal carcinoma (NPC) remain unclear. The present study demonstrated that miR-223 was downregulated in NPC cell lines.

Penetrating neck trauma caused by a rebar: A case report.

Rationale: Penetrating neck trauma has a mortality of 3% to 6% and is associated with serious complications, mainly due to the high density of vital structures in this area and the lack of corresponding protection from bone.

Patient Concerns: A 55-year-old man who suffered neck trauma involving the parotid gland, caused by a rebar, after suffering a fall from the second floor of a building.

Diagnoses: Penetrating neck trauma.

Facile microencapsulation of olive oil in porous starch granules: Fabrication, characterization, and oxidative stability.

In this study, starch with porous structures derived from purple sweet potato was prepared and used as a food-grade polymer for the microencapsulation of olive oil. The optimal reaction conditions for preparing porous starch were determined to improve its adsorption capacity as effective microcapsule-wall materials. Olive oil was then impregnated in microspheres, and loading ratio was optimized by investigating the restrictive factors, including the mass ratio of olive oil to porous starch, as well as the embedding temperature and time.

Effect of Kruppel-like factor 4 on Notch pathway in hepatic stellate cells.

The relationship between Kruppel-like factor 4 (KLF4) and the Notch pathway was determined to investigate the effect of KLF4 on the activation of hepatic stellate cells and underlying mechanisms. Fifty SPF BALB/c mice were randomly divided into two groups. A liver fibrosis model was established in 25 mice as the experimental group, and the remaining 25 mice served as controls.

[Application of CO2 laser and self-made laryngeal dilator in the treatment of the laryngeal stenosis].

Objective: To study the treatment effect of CO2 laser and self-made laryngeal dilator on the laryngeal stenosis.

Method: Twenty-five patients with laryngeal stenosis were treated with CO2 laser and self-made laryngeal dilator. The laryngeal cavity scar was resected as much as possible by using CO2 laser and the laryngeal cavity was exposed by placing laryngeal dilator under general anesthesia.

miR-205 promotes proliferation and invasion of laryngeal squamous cell carcinoma by suppressing CDK2AP1 expression.

Background: The aberrant expression of microRNAs (miRNAs) has been found in various types of cancer. miR-205 was reported to be upregulated in laryngeal squamous cell carcinoma (LSCC) tissues, however, the mechanisms by which miR-205 functions as a regulator of LSCC are largely unknown.

Results: In this study, Real-time qPCR and Western blot assay showed that expression of miR-205 was upregulated and expression of cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) was downregulated in LSCC tissues.

[Utilization of functional neck dissection for treatment of recurrent branchial cleft anomalies].

Objective: To evaluate the utilization of functional neck dissection for treatment of recurrent branchial cleft anomalies.

Method: Fifteen patients with recurrent branchial cleft anomalies (fistula and cyst) undergoing functional neck dissection were retrospectively analyzed.

Result: Complications included 2 incisions secondary healing, 1 postoperative choking persisting for 1 months and 1 Horner's syndrome.

Trans-superior meatus endoscopic surgery of sphenoidal sinus and sellar area: a surgical technique for lesion of sellar area.

Conclusion: A trans-superior meatus endoscopic approach to treat diseases in the sphenoid sinus and sellar area is a safe, minimally traumatic, and effective method.

Objective: To avoid complications, we explored the use of the superior meatus and superior turbinate in the endoscope approach to the sphenoid sinus and sellar area.

Patients And Methods: This was a retrospective analysis of the curative effect of the trans-superior meatus approach for diseases in the sphenoid sinus and sellar area in 138 cases.

[The effects of endoscopic sinus surgery on nasality and nasal patency].

Objective: The purpose of this study was to describe the changes of resonance characteristics of the nasal cavity (including nasal sinuses) and nasal airway resistance (NAR) after endoscopic sinus surgery (ESS), through objective measurement of nasality and NAR before and after ESS.

Method: Sixty- eight patients received the examinations of nasality and NAR using Nanometer and Atmos Rhinomanometry before and after ESS separately.

Result: The nasality of patients with type III and type II stage 2, stage 3 chronic sinusitis was obviously improved ( P <0.

[The diagnosis and treatment of special airway foreign body].

Objective: The aim of this study was to discuss the diagnosis and treatment of special airway foreign body.

Method: Clinical data of 69 patients with airway foreign body were analyzed,of which 45 patients underwent rigid bronchoscopy while another 24 patients underwent tracheotomy.

Result: The operations succeeded in 43 of the 45 patients who underwent rigid bronchoscopy, while the other 2 patients died of respiratory failure because of the foreign body slipping off at the level of the glottis.

[Cause and treatment of trachea cannula exodus after executed tracheotomy].

Objective: To explore the reason and correct management of trachea cannula exodus in the patient who had been executed tracheotomy, and reduce the occurrence of trachea cannula exodus and its complication.

Method: To analysis retrospectively 23 cases of trachea cannula exodus after executed tracheotomy in patients who had been obstructed in upper respiratory.

Result: In 23 cases of trachea cannula exodus, 21 cases were rescued succeeded, 1 case death, 1 case became plant man.

[The expressions of survivin and VEGF in squamous cell carcinoma of larynx and the correlation between the two marks].

Objective: To study the expressions and biological behavior of Survivin and VEGF in squamous cell carcinoma of larynx (LSCC) and the correlation between Survivin and VEGF.

Method: The expressions of Survivin and VEGF in LSCC tissues of 40 cases and normal mucosa of larynx tissues of 5 cases were studied by immunohistochemical staining.

Result: The expressions of Survivin and VEGF in LSCC tissues were higher than those in normal mucosa of laryngeal cavity (P <0.

[Image examination of postoperative evaluation for the cochlear implanted electrode].

Objective: To evaluate the image feature of the X-ray plain film, the spiral computed tomography (CT) scans and three dimension reconstruction of inner ear with implanted electrode.

Methods: Eighteen patients of cochlear implant (MEDEL Combi 40+) recipients were involved in this study. The implanted electrode of all patients were examined on the fifth to seventh postoperative day, by the use of X-ray plain film with either anteroposterior transorbital projection (nine cases) or lateral position with coronal 60 degrees away from the examine table (nine cases).

[Integrated methods for assessing auditory nerve-auditory pathway integrity].

Objective: To evaluate the feasibility and value of integrated methods to assess auditory pathway integrity.

Method: Twenty-four cases of bilateral profoundly-deafened individuals who were considered as the candidates of cochlear implantation were included in this study. Auditory pathway integrity from these candidates of cochlear implantation were assessed with the integrated methods established by our team, which consist of 5 categories including 1.

[Benefit of bilateral cochlear implantation on congenital prelingually deafened Chinese-speaking children].

Objective: To evaluate the benefit of bilateral cochlear implants (BCIs) in prelingually deafened children on hearing rehabilitation as well as on speech and language development.

Method: Two cases of congenital profound deaf children, who received unilateral cochlear implantation (CI, MEDEL C40+) on the age of 2 and 7.5, respectively, were performed secondary CI in the contralateral ear on their age of 5 and 9.