A nomogram for predicting skin necrosis risk after open reduction and internal fixation for tibia fractures.

The purpose of our study was to determine the risk factors for skin necrosis after open reduction and internal fixation (ORIF) for tibia fracture and establish a nomogram prediction model. We retrospectively analysed the clinical data of patients who suffered from tibia fractures and had been surgically treated by ORIF in our institution between August 2015 and October 2020. Perioperative information was obtained through the electronic medical record system, univariate and multivariate analyses were performed to determine the risk factors of skin necrosis, and a nomogram model was constructed to predict the risk of skin necrosis.

A Novel Classification Framework Using the Graph Representations of Electroencephalogram for Motor Imagery Based Brain-Computer Interface.

The motor imagery (MI) based brain-computer interfaces (BCIs) have been proposed as a potential physical rehabilitation technology. However, the low classification accuracy achievable with MI tasks is still a challenge when building effective BCI systems. We propose a novel MI classification model based on measurement of functional connectivity between brain regions and graph theory.

Clinical and Functional Outcomes of Total Knee Arthroplasty in Sarcopenia: A Case-Control Retrospective Cohort Study.

Background:  The aim of the study was to investigate the relationship between sarcopenia and both clinical and functional outcome scores following total knee arthroplasty (TKA) performed for patients over 65 years of age.

Methods:  We assessed patient demographics, preoperative health status, postoperative Knee Society Clinical (KSS-C) and Function (KSS-F) subscores, and perioperative complications for 180 patients with sarcopenia and 345 comparatively healthy patients at a mean of 12.0 months after surgery.

Progress and Perspective on Carbon-Based Nanozymes for Peroxidase-like Applications.

Tumor microenvironment-responsive chemodynamic therapy (CDT), an approach based on Fenton/Fenton-like reaction to convert hydrogen peroxide (HO) into the highly cytotoxic hydroxyl radical (·OH) to kill cancer cells, represents an important direction for cancer therapy. Different types of nanozymes (nanomaterial-based catalysts that can mimic the activities of natural enzymes) have been developed to mimic peroxidase. This Perspective highlights the latest research progress regarding low-cost and biocompatible carbon-based nanozymes for peroxidase mimics.

Study on Multi-Model Soft Sensor Modeling Method and Its Model Optimization for the Fermentation Process of .

The problems that the key biomass variables in fermentation process are difficult measure in real time; this paper mainly proposes a multi-model soft sensor modeling method based on the piecewise affine (PWA) modeling method, which is optimized by particle swarm optimization (PSO) with an improved compression factor (ICF). Firstly, the false nearest neighbor method was used to determine the order of the PWA model. Secondly, the ICF-PSO algorithm was proposed to cooperatively optimize the number of PWA models and the parameters of each local model.

In situ immobilization of silver nanocrystals in carbon nanoparticles for intracellular fluorescence imaging and hydroxyl radicals detection.

Silver nanoparticles (Ag NPs) have attracted extensive research interest in bioimaging and biosensing due to their unique surface plasmon resonance. However, the potential aggregation and security anxiety of Ag NPs hinder their further application in biomedical field due to their high surface energy and the possible ionization. Here, binary heterogeneous nanocomplexes constructed from silver nanoparticles and carbon nanomaterials (termed as C-Ag NPs) were reported.

Comparison of vacuum sealing drainage and conventional drainage for postoperative drainage in closed calcaneal fracture: A randomized controlled trial.

Background: The objective of this study was to compare the outcomes of vacuum sealing drainage (VSD) and conventional drainage after surgery in the treatment of closed calcaneal fracture. We hypothesize that VSD is superior to conventional drainage in reducing volume of drainage, time of wound drying, time of skin fold, time of wound healing, VAS at day 3 postoperatively, wound complications and increasing wound healing grade.

Methods: 120 patients with closed calcaneal fractures from January 2016 to December 2018 were enrolled in our study.

Development and Validation of an Autophagy-Related Gene Signature for Predicting the Prognosis of Hepatocellular Carcinoma.

Purpose: Autophagy is a lysosomal degradation pathway that is essential for maintaining the homeostasis of the intracellular environment. Mounting evidence indicates that autophagy plays an essential role in the occurrence and development of hepatocellular cancer (HCC). This research is aimed at exploring the prognostic value of autophagy-related genes (ARGs) in HCC patients.

Stabilizing MXene by Hydration Chemistry in Aqueous Solution.

MXenes attract interest in diverse fields but suffer from fast structural degradation by attacking of dissolved oxygen and water molecules in aqueous solution. This drawback hinders the long-term storage, applications and understanding of the chemical nature of MXenes. Herein, we report a cost-effective and environmentally sustainable way for long-term storage of MXenes in aqueous solution by hydration chemistry of nontoxic inorganic salts.

Effect of PLC-β1/CaM signaling pathway mediated by AT1R on the occurrence and development of hepatocellular carcinoma.

Objective: To study the roles of AT1R, PLC-β1, CaM and other related signal molecules in the formation and development of hepatocellular carcinoma (HCC) and their correlation.

Methods: ELISA and immunohistochemistry were used to analyze the expressions of target proteins in serum and liver tissue of HCC patients, and the correlation between AT1R, PLC-β1 and CaM and postoperative survival status of patients was followed up and determined. CCK-8 method was used to screen the doses of Ang II and candesartan sensitive to HepG2 and HCCLM3 cells.

GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation.

Spinal cord injury (SCI) refers to a major worldwide cause of accidental death and disability. However, the complexity of the pathophysiological mechanism can result in less-effective clinical treatment. Growth differentiation factor 11 (GDF-11), an antiageing factor, was reported to affect the development of neurogenesis and exert a neuroprotective effect after cerebral ischaemic injury.

Free Space Measurement Device Independent Quantum Key Distribution with Modulating Retro-Reflectors under Correlated Turbulent Channel.

Modulating retro-reflector (MRR), originally introduced to support laser communication, relieves most of the weight, power, and pointing requirements to the ground station. In this paper, a plug-and-play measurement device independent quantum key distribution (MDI-QKD) scheme with MRR is proposed not only to eliminate detector side channels and allow an untrusted satellite relay between two users, but also to simplify the requirements set-ups in practical flexible moving scenarios. The plug-and-play architecture compensates for the polarization drift during the transmission to provide superior performance in implementing the MDI-QKD on a free-space channel, and the MRR device is adopted to relax the requirements on both communication terminals.

A pair of dopamine neurons mediate chronic stress signals to induce learning deficit in .

Chronic stress could induce severe cognitive impairments. Despite extensive investigations in mammalian models, the underlying mechanisms remain obscure. Here, we show that chronic stress could induce dramatic learning and memory deficits in The chronic stress-induced learning deficit (CSLD) is long lasting and associated with other depression-like behaviors.

Robust Similarity Measurement Based on a Novel Time Filter for SSVEPs Detection.

The steady-state visual evoked potential (SSVEP)-based brain-computer interface (BCI) has received extensive attention in research for the less training time, excellent recognition performance, and high information translate rate. At present, most of the powerful SSVEPs detection methods are similarity measurements based on spatial filters and Pearson's correlation coefficient. Among them, the task-related component analysis (TRCA)-based method and its variant, the ensemble TRCA (eTRCA)-based method, are two methods with high performance and great potential.

Cyclic helix B peptide promotes random-pattern skin flap survival via TFE3-mediated enhancement of autophagy and reduction of ROS levels.

Background And Purpose: Necrosis of random-pattern skin flaps limits their clinical application. Helix B surface peptide (HBSP) protects tissues from ischaemia-reperfusion injury but its short plasma half-life limits its applications. Here, we have synthesized cyclic helix B peptide (CHBP) and investigated its role in flap survival and the underlying mechanisms.

Prognostic value of CD169-positive macrophages in various tumors: a meta-analysis.

The study aimed to evaluate the prognostic value of CD169 expression in tumor-infiltrating macrophages from regional lymph nodes (RLN) in various tumors. In order to identify eligible articles, PubMed, EMBASE, Web of Science, and Cochrane Library were used to conduct a systematic search. Pooled hazard ratios (HRs) or odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were adopted to assess the relationship between CD169 expression and overall survival (OS) and clinicopathological characteristics.

Evaluation of color modulation in visual P300-speller using new stimulus patterns.

The stimulus color of P300-BCI systems has been successfully modified. However, the effects of different color combinations have not been widely investigated. In this study, we designed new stimulus patterns to evaluate the influence of color modulation on the BCI performance and waveforms of the evoked related potential (ERP).

Influence of Source Parameters on the Polarization Properties of Beams for Practical Free-Space Quantum Key Distribution.

Polarization encoding has been extensively used in quantum key distribution (QKD) implementations along free-space links. However, the calculation model to characterize channel transmittance and quantum bit error rate (QBER) for free-space QKD has not been systematically studied. As a result, it is often assumed that misalignment error is equal to a fixed value, which is not theoretically rigorous.

Elevated Systemic and Intestinal Inflammatory Response Are Associated With Gut Microbiome Disorder After Cardiovascular Surgery.

Systemic inflammatory response after cardiovascular surgery is associated with poor prognosis, to which gut barrier impairment is related. To investigate whether perioperative changes of the gut microbiome are associated with systemic and intestinal inflammatory response, we examined changes of the gut microbiome, intestinal homeostasis, and systemic inflammatory response in cardiovascular patients before (Pre) surgery and on the first defecation day [postoperative time 1 (Po1)] or a week [postoperative time 2 (Po2)] postsurgery. Markedly, the enhanced systemic inflammatory response was observed in Po1 and Po2 compared with that in Pre.

Characterization of the metabolite of cabozantinib generated from liver microsomes and hepatocytes by ultra-high performance liquid chromatography coupled to quadrupole/orbitrap high resolution mass spectrometry.

Cabozantinib is a potent inhibitor of tyrosine kinase receptor that plays key role in tumor pathogenesis. Cabozantinib has been approved by U. S.

Peony seed oil ameliorates neuroinflammation-mediated cognitive deficits by suppressing microglial activation through inhibition of NF-κB pathway in presenilin 1/2 conditional double knockout mice.

Chronic neuroinflammation has been shown to exert adverse influences on the pathology of Alzheimer's disease (AD), associated with the release of abundant proinflammatory mediators by excessively activated microglia, causing synaptic dysfunction, neuronal degeneration, and memory deficits. Thus, the prevention of microglial activation-associated neuroinflammation is important target for deterring neurodegenerative disorders. Peony seed oil (PSO) is a new food resource, rich in α-linolenic acid, the precursor of long chain omega-3 polyunsaturated fatty acids, including docosahexaenoic acid and eicosapentaenoic acid, which exhibit anti-inflammatory properties by altering cell membrane phospholipid fatty acid compositions, disrupting lipid rafts, and inhibiting the activation of the proinflammatory transcription factor NF-κB.

A MEMS Fabrication Process with Thermal-Oxide Releasing Barriers and Polysilicon Sacrificial Layers for AlN Lamb-Wave Resonators to Achieve · > 3.42 × 10.

This paper presents a micro-electro-mechanical systems (MEMS) processing technology for Aluminum Nitride (AlN) Lamb-wave resonators (LWRs). Two LWRs with different frequencies of 402.1 MHz and 2.

Rapid removal of chloramphenicol via the synergy of Geobacter and metal oxide nanoparticles.

The wide use of chloramphenicol and its residues in the environments are an increasing threat to human beings. Electroactive microorganisms were proven with the ability of biodegradation of chloramphenicol, but the removal rate and efficiency need to be improved. In this study, a model electricigens, Geobacter metallireducens, was supplied with and FeO and MnO nanoparticles.

Effect of parental arterial stiffness in offspring: the Kailuan study.

Objective: The aim of this study was to examine effect of parental arterial stiffness in offspring.

Methods: The individuals who participated in the second or subsequent follow-up and had parent-offspring relationship and completed measurements of brachial-ankle pulse wave velocity (baPWV) from the Kailuan study were recruited. The individuals were divided into groups by the 10-year intervals and sex.