Hierarchical 0D-2D Co/Mo Selenides as Superior Bifunctional Electrocatalysts for Overall Water Splitting.

Development of efficient electrocatalysts combining the features of low cost and high performance for both the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) still remains a critical challenge. Here, we proposed a facile strategy to construct a novel hierarchical heterostructure composed of 0D-2D CoSe/MoSe by the selenization of CoMoO nanosheets grafted on a carbon cloth (CC). In such integrated structure, CoSe nanoparticles dispersed well and tightly bonded with MoSe nanosheets, which can not only enhance kinetics due to the synergetic effects, thus promoting the electrocatalytic activity, but also effectively improve the structural stability.

Interplay of curcumin and its liver metabolism on the level of Aβ in the brain of APP/PS1 mice before AD onset.

Background: An increasing number of studies have shown that Alzheimer's disease (AD) is a systemic disease characterized by brain dysfunction. In this study, we aimed to investigate the effects of curcumin on the liver, an important metabolic organ, and on the brain in APP/PS1 (APP/PS1) mice, and the interaction between these effects.

Methods: Curcumin was administered to 5-month-old APP/PS1 transgenic mice for 7 consecutive days using the intragastric (ig) and intracerebroventricular (icv) administration routes, respectively.

Bilayer Anion-Exchange Membrane with Low Borohydride Crossover and Improved Fuel Efficiency for Direct Borohdyride Fuel Cell.

The development of membranes with low fuel crossover and high fuel efficiency is a key issue in direct borohydride fuel cells (DBFCs). In previous work, we produced a poly(vinyl alcohol) (PVA)-anion-exchange resin (AER) membrane with a low fuel crossover and a low fuel efficiency by introducing Co ions. In this work, a bilayer membrane was designed to improve the fuel efficiency and cell performance.

Two-Dimensional Multifunctional Metal-Organic Frameworks with Simultaneous Ferro-/Ferrimagnetism and Vertical Ferroelectricity.

Exploring 2D multifunctional materials with intrinsic ferro-/ferrimagnetism and vertical ferroelectricity is a highly desirable but challenging task. Here, motivated by the recently synthesized organometallic frameworks KFe[PcFeO], we propose to realize such materials in a series of 2D KM[PcMO] (M = Cr-Co) nanosheets. First-principles calculations suggest 2D KCr[PcCrO] as a ferromagnetic half metal with a Curie temperature of 140 K, whereas others (M = Mn, Fe, and Co) are all ferrimagnetic semiconductors with the Curie temperatures between 66 and 150 K.

Entecavir therapy reverses gut microbiota dysbiosis induced by hepatitis B virus infection in a mouse model.

Introduction: Chronic hepatitis B virus (HBV) infection is a global public health problem. The gut microbiota has been linked to pathogenesis of liver diseases induced by chronic HBV infection.

Methods And Results: This study established a recombinant adeno-associated virus serotype 8 (rAAV8)-mediated persistent HBV infection mouse model.

Robust Biomimetic Hierarchical Diamond Architecture with a Self-Cleaning, Antibacterial, and Antibiofouling Surface.

Biofouling is a worldwide problem from healthcare to marine exploration. Aggressive biofouling, wear, and corrosion lead to severe deterioration in function and durability. Here, micro- and nanostructured hierarchical diamond films mimicking the morphology of plant leaves were developed to simultaneously achieve superhydrophobicity, antibacterial efficacy, and marine antibiofouling, combined with mechanical and chemical robustness.

Efficient interlayer charge release for high-performance layered thermoelectrics.

Many layered superlattice materials intrinsically possess large Seebeck coefficient and low lattice thermal conductivity, but poor electrical conductivity because of the interlayer transport barrier for charges, which has become a stumbling block for achieving high thermoelectric performance. Herein, taking BiCuSeO superlattice as an example, it is demonstrated that efficient interlayer charge release can increase carrier concentration, thereby activating multiple Fermi pockets through Bi/Cu dual vacancies and Pb codoping. Experimental results reveal that the extrinsic charges, which are introduced by Pb and initially trapped in the charge-reservoir [BiO] sublayers, are effectively released into [CuSe] sublayers via the channels bridged by Bi/Cu dual vacancies.

Thymoglobulin vs. ATG-Fresenius as Induction Therapy in Kidney Transplantation: A Bayesian Network Meta-Analysis of Randomized Controlled Trials.

Thymoglobulin (THG) and antithymocyte globulin-Fresenius (ATG-F) have not been compared directly as induction therapies in kidney transplantation. We performed a Bayesian network meta-analysis to compare THG with ATG-F by pooling direct and indirect evidence. Surface under the cumulative ranking curve (SUCRA) values were used to compare the superiority of one method over the other.

Research progress on sirtuins family members and cell senescence.

Human aging is a phenomenon of gradual decline and loss of cell, tissue, organ and other functions under the action of external environment and internal factors. It is mainly related to genomic instability, telomere wear, mitochondrial dysfunction, protein balance disorder, antioxidant damage, microRNA expression disorder and so on. Sirtuins protein is a kind of deacetylase which can regulate cell metabolism and participate in a variety of cell physiological functions.

Identification of a functional human-unique 351-bp Alu insertion polymorphism associated with major depressive disorder in the 1p31.1 GWAS risk loci.

Genome-wide association studies (GWAS) have reported substantial single-nucleotide polymorphisms (SNPs) associated with major depressive disorder (MDD), but the underlying functional variations in the GWAS risk loci are unclear. Here we show that the European MDD genome-wide risk-associated allele of rs12129573 at 1p31.1 is associated with MDD in Han Chinese, and this SNP is in strong linkage disequilibrium (LD) with a human-unique Alu insertion polymorphism (rs70959274) in the 5' flanking region of a long non-coding RNA (lncRNA) LINC01360 (Long Intergenic Non-Protein Coding RNA 1360), which is preferably expressed in human testis in the currently available expression datasets.

Single-cell in vivo imaging of cellular circadian oscillators in zebrafish.

The circadian clock is a cell-autonomous time-keeping mechanism established gradually during embryonic development. Here, we generated a transgenic zebrafish line carrying a destabilized fluorescent protein driven by the promoter of a core clock gene, nr1d1, to report in vivo circadian rhythm at the single-cell level. By time-lapse imaging of this fish line and 3D reconstruction, we observed the sequential initiation of the reporter expression starting at photoreceptors in the pineal gland, then spreading to the cells in other brain regions at the single-cell level.

Multiple Tolerance and Dye Decolorization Ability of a Novel Laccase Identified from .

Laccases are multicopper oxidases with important industrial value. In the study, a novel laccase gene (mco) in a isolate is identified and heterologously expressed in . Mco shares less than 40% of amino acid sequence identities with the other characterized laccases, exhibiting the maximal activity at pH 4.

Atomic-Level Construction of Tensile-Strained PdFe Alloy Surface toward Highly Efficient Oxygen Reduction Electrocatalysis.

Exploring the high-performance non-Pt electrocatalysts for oxygen reduction reaction (ORR), the bottleneck process in fuel cells, is desirable but challenging. Here, we report the Pd@PdFe core-shell icosahedra as an active and durable electrocatalyst toward ORR in alkaline conditions, which feature a three-atomic-layer tensile-strained PdFe overlayer on Pd icosahedra. Our optimized catalyst shows 2.

Comparative peptidome profiling reveals critical roles for peptides in the pathology of pancreatic cancer.

Backgrounds/aims: Pancreatic cancer is a digestive system tumour disease with a notably poor prognosis and a 5-year survival rate of less than 10 %. In recent years, peptide drugs have shown great clinical value in antitumour applications. We aim to identify differentially expressed peptides by using peptidomics techniques to explore the mechanisms involved in the development and pathology of pancreatic cancer.

Increasing Time in Therapeutic Range of Tacrolimus in the First Year Predicts Better Outcomes in Living-Donor Kidney Transplantation.

The aim of the present study was to investigate the impact of time in therapeutic range TTR on long-term outcomes of living kidney transplants. We included 1,241 living kidney transplants and randomized them into development and validation cohorts with a ratio of 2:1. The tacrolimus TTR percentage was calculated by linear interpolation with a target range (5-10 ng/ml months 0-3, 4-8 ng/ml months 4-12).

Construction of β-FeOOH@tunicate cellulose nanocomposite hydrogels and their highly efficient photocatalytic properties.

The environmentally friendly materials fabricated from renewable marine resources have aroused worldwide concerns. Here, for the first time, tunicate cellulose was dissolved in LiOH/urea aqueous solution at -12 °C after ball-milling, and its molecular weight was determined with laser light scattering. Hydrogels were fabricated from the cellulose solution by regenerating in ethanol, and β-FeOOH nanoparticles (NPs) were in-situ synthesized to obtain β-FeOOH/cellulose composite hydrogels (TCH-Fe).

The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population.

Major depressive disorder (MDD) is recognized as a primary cause of disability worldwide, and effective management of this illness has been a great challenge. While genetic component is supposed to play pivotal roles in MDD pathogenesis, the genetic and phenotypic heterogeneity of the illness has hampered the discovery of its genetic determinants. In this study, in an independent Han Chinese sample (1824 MDD cases and 3031 controls), we conducted replication analyses of two genetic loci highlighted in a previous Chinese MDD genome-wide association study (GWAS), and confirmed the significant association of a single nucleotide polymorphism (SNP) rs12415800 near SIRT1.

Butyrate protects against high-fat diet-induced atherosclerosis via up-regulating ABCA1 expression in apolipoprotein E-deficiency mice.

Background And Purpose: The gut microbial metabolite butyrate is linked to the modulation of metabolic disease. The mechanism by which butyrate effects in atherosclerosis is unknown. Hence, the present investigation into effects of butyrate on high-fat diet-fed ApoE mice after 16 weeks' administration.

A concise review of recent advances in anti-heart failure targets and its small molecules inhibitors in recent years.

Heart failure is a disease with high mortality and the risk of heart failure increases in magnitude with age. The patients of heart failure is increasing year by year. Hence, Pharmaceutical researchers have to develop new drugs with better pharmacological effects to coping with this phenomenon.

TGF-β- and lipopolysaccharide-induced upregulation of circular RNA PWWP2A promotes hepatic fibrosis via sponging miR-203 and miR-223.

Both transforming growth factor-beta (TGF-β) and lipopolysaccharide (LPS) can activate hepatic stellate cells (HSCs), thus increasing expressions of alpha smooth muscle actin (α-SMA) and type I collagen alpha 1 (Col1α1) and promoting liver fibrosis. However, whether TGF-β and LPS have a common downstream reactor remains unclear. Recently, a strong relationship of circular RNAs (circRNAs) and fibrogenesis has been elucidated.

Unconventional p-d Hybridization Interaction in PtGa Ultrathin Nanowires Boosts Oxygen Reduction Electrocatalysis.

Alloying 3d transition metals with Pt has been discovered as an effective strategy to boost the catalytic activity in oxygen reduction reaction (ORR), which, however, often raises the insufficient catalyst durability issue due to rapid leaching of the 3d metal elements. To overcome this issue and realize enhancements in both the activity and the durability properties, here we report a new catalytic structure based on PtGa ultrathin alloy nanowires (NWs), which feature an unconventional strong p-d hybridization interaction. Relative to commercial Pt catalyst, the optimum PtGa NWs catalyst exhibited 10.