Unraveling Key mA Modification Regulators Signatures in Postmenopausal Osteoporosis through Bioinformatics and Experimental Verification.

Objective: Bone marrow mesenchymal stem cells (BMSCs) show significant potential for osteogenic differentiation. However, the underlying mechanisms of osteogenic capability in osteoporosis-derived BMSCs (OP-BMSCs) remain unclear. This study aims to explore the impact of YTHDF3 (YTH N6-methyladenosine RNA binding protein 3) on the osteogenic traits of OP-BMSCs and identify potential therapeutic targets to boost their bone formation ability.

Three new tyrosol derivatives from Huangjing wine.

Phytochemical investigation on the concentrate of Huangjing wine, resulted in the isolation of three new tyrosol derivatives 4-hydroxyphenethyl 2-(R)-hydroxy-3-phenylpropionate (), 4-hydroxyphenethyl(4-hydroxy-3-methoxyphenyl)propionate () and 4-hydroxyphenethyl ethyl succinate (), together with 5 known compounds, ferulic acid (), L-phenyllactic acid (), hydroxytyrosol (), dihydroferulic acid (), cyclo(L-Pro-D-Tyr) (). Their structures were elucidated using spectroscopic analysis and by comparison with the literature data. All compounds displayed antioxidant effect in the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical.

Nitric Oxide-Driven Nanomotor for Deep Tissue Penetration and Multidrug Resistance Reversal in Cancer Therapy.

Poor permeation of therapeutic agents and multidrug resistance (MDR) in solid tumors are the two major challenges that lead to the failure of the current chemotherapy methods. Herein, a zero-waste doxorubicin-loaded heparin/folic acid/l-arginine (HFLA-DOX) nanomotor with motion ability and sustained release of nitric oxide (NO) to achieve deep drug penetration and effective reversal of MDR in cancer chemotherapy is designed. The targeted recognition, penetration of blood vessels, intercellular penetration, special intracellular distribution (escaping from lysosomes and accumulating in Golgi and nucleus), 3D multicellular tumor spheroids (3D MTSs) penetration, degradation of tumor extracellular matrix (ECM), and reversal of MDR based on the synergistic effects of the motion ability and sustained NO release performance of the NO-driven nanomotors are investigated in detail.

Combination of D-dimer and simplified pulmonary embolism severity index to improve prediction of hospital death in patients with acute pulmonary embolism.

Objective: To investigate whether the combination of D-dimer and simplified pulmonary embolism severity index (sPESI) could improve prediction of in-hospital death from pulmonary embolism (PE).

Methods: Patients with PE (n = 272) were divided into a surviving group (n = 249) and an in-hospital death group (n = 23).

Results: Compared with surviving patients, patients who died in hospital had significantly higher rates of hypotension and tachycardia, reduced SaO levels, elevated D-dimer and troponin T levels, higher sPESI scores, and were more likely to be classified as high risk.

A case of fourth atlanto-axial facet joint: anatomical description.

Purpose: To report a rare fourth atlanto-axial joint.

Methods: A cadaveric specimen of a young male adult from occiput to C4 was dissected for anatomical study of craniocervical region. A true fourth atlanto-axial joint was confirmed.

Distribution and conservation status of Rhinopithecus strykeri in China.

This paper summarizes the results of 358 interviews we conducted on Rhinopithecus strykeri in the Gaoligong Mountains, northwest Yunnan, China, between April 2011 and December 2012. Based on our interview records and selective field surveys (47 days of field survey for seven possible distribution areas), we suggest that there may be up to 10 groups of R. strykeri occurring in China between the Salween River and the border with Myanmar, and that the total population of R.

Expression of RRM1 and RRM2 as a novel prognostic marker in advanced non-small cell lung cancer receiving chemotherapy.

The aim of this study was to examine the prognostic value of BRCA1, RRM1, and RRM2 in patients with non-small cell lung cancer (NSCLC) who received adjuvant chemotherapy. A total of 418 patients who underwent curative pulmonary resection were obtained between January 2007 and November 2009. The relative cDNA quantification for BRCA1, RRM1, and RRM2 was conducted using a fluorescence-based, real-time detection method, and β-actin was used as a reference gene.

[An analysis of surgical outcome and influencing factors in patients of congenital basilar invagination with atlantal-axial dislocation: report of 120 cases].

Objective: To investigate the surgical outcome and its influencing factors in patients of congenital basilar invagination (BI) with atlanto-axial dislocation (AAD).

Methods: From May 2004 to August 2010, 120 patients who had BI with AAD were surgically treated with direct posterior intraoperative distraction-reduction and fixation technique, 93 patients were successfully followed up by means of questionnaire survey, telephone and clinical evaluation. Pre- and postoperative dynamic cervical X-rays, computed tomographic scans, 3-dimentional reconstruction views and magnetic resonance imaging were performed.

Feasibility and limitations of C1 lateral mass screw placement in patients of atlas assimilation.

Background: C1 lateral mass is a common place for screw fixation in normal anatomy; whereas there is no research about whether screw placement is suitable in patients of C1 assimilation (C1A).

Objective: To study the feasibility and limitations of C1 lateral mass screw placement in patients with C1A.

Patients And Methods: From April 2008 to March 2009, C1 lateral mass of 17 C1A patients with atlantoaxial instability (AAI) or dislocation (AAD) was observed and measured using CT reconstruction; and factors determining C1 lateral mass screw placement were studied before and during the operation.

[A coal mine and coal preparation plant coal dust workplace present situation investigation and analysis].

Objective: Through a detection of dust in the coal mines workplace, to understand the status of occupational hazards, and the evaluation of occupational hazards, provide subject to control occupational hazards.

Method: According to production process and "hazardous substances in workplace air monitoring, sampling norms" and other standards to determine the sampling points and sampling of coal dust.

Result: Underground mining operations in 21 subjects with time-weighted average concentration of dust types pass rate of 28.

2-[(2-Hy-droxy-4-meth-oxy-benzyl-idene)aza-nium-yl]benzoate monohydrate.

In the title compound, C(15)H(13)NO(4)·H(2)O, the Schiff base exists in a zwitterionic form and a bifurcated intra-molecular N-H⋯(O,O) hydrogen bond generates two S(6) rings. The dihedral angle between the two benzene rings is 25.8 (2)°.

[Effect of actovegin on intestinal mucosa and expression of bcl-2/bax genes in rats with acute radiation enteritis].

Objective: To evaluate the effect of actovegin (Nycomed, deproteinized hemoderivative of calf blood injection) on intestinal mucosa in rats with acute radiation enteritis, and observe the changes of expression of apoptosis-related bcl-2/bax genes.

Methods: An abdominal irradiation in a dose of 9.0 Gy X-ray of linear accelerator was performed once on a group of Wistar rats to establish a model of acute intestinal radiation enteritis.

[Prodrug structural modifications of cyclovirobuxine D and their biological activity].

Aim: To search for compounds for the treatment of cardiovascular diseases through prodrug structural modifications of cyclovirobuxine D, a single efficient composition distilled from Box plant in China, which was used to treat angina and myocardial infarction.

Methods: According to prodrug design principle, a series of cyclovirobuxine D analogues were prepared, suc as succinate, phosphate and amino acid ester, and their biological activities were tested.

Results: Seven new compounds were obtained and confirmed with 1H NMR, MS, and element analysis.

[Minimally invasive surgery of the spinal cord hemangioblastoma].

Objective: To clarify and discuss the diagnosis and minimally invasive surgery of spinal cord hemangioblastoma.

Methods: The clinical data of 16 patients with spinal cord hemangioblastoma who were operated on between 1992 and 2001 were analyzed retrospectively with a review of the literature.

Results: Twelve patients were subjected to MRI examination, nine to spinal cord angiography, and six to preoperative embolization.

[Structural modification and bioactivity of cyclovirobuxine D].

Aim: To search for new compounds for the treatment of cardiovascular diseases by structural modification of cyclovirobuxine D.

Methods: According to rational drug design principle, a series of cyclovirobuxine D analogues were prepared, and their bioactivities were tested.

Results: Ten new compounds were syntheized and confirmed by spectra.