Complete mitochondrial genome of freshwater goby (Perciformes, Gobiidae): genome characterization and phylogenetic analysis.

In this study, we present the complete mitochondrial genome of , sequenced using the Illumina HiSeq platform. The result is a circular mitogenome of 16,500 base pairs (bp) with a pronounced A + T nucleotide bias. Phylogenetic analysis was conducted using both Bayesian inference (BI) and maximum-likelihood (ML) methods, utilizing the complete mitochondrial genomes of and 19 additional species.

Complete mitochondrial genome and phylogenetic analysis of (Teleostei, Cypriniformes, Danionidae).

, collected from Gadu River in Yingjiang area, Yunnan Province, China, had been sequenced on Illumina HiSeq platform with 16523 bp in length, which included 37 genes encoding 13 proteins-coding genes (PCGs), 22 tRNAs, 2 rRNAs and a displacement loop region. The proportion of nucleotides in mitochondrial genome was T (28.7%), C (23.

Profibrotic effect of miR-33a with Akt activation in hepatic stellate cells.

MicroRNAs (miRNAs) attract more attention in the pathophysiology of liver fibrosis and miR-33a has been previously demonstrated as involved in the regulation of cholesterol and lipid metabolism. Transforming growth factor-beta1 (TGF-β1) is generally accepted to be the main stimulating factor in the hepatic stellate cells (HSCs) activation, which plays an important role in hepatic fibrosis. However, the involvement and underlying mechanism of miR-33a and its role in TGF-β1-induced hepatic fibrogenesis remains unknown.

The bone morphogenetic protein antagonist Gremlin is overexpressed in human malignant mesothelioma.

Gremlin is a member of the bone morphogenetic protein (BMP) antagonist family and its antagonistic effect is likely through direct binding to BMP proteins. As an antagonist of BMP, Gremlin plays a role in regulating organogenesis, body patterning and tissue differentiation. Recent studies have shown a deregulation of Gremlin in several types of human cancers.

[Correlation between expression of excision repair cross-complementing 1 and cisplatin sensitivity in non-small cell lung cancer].

Objective: To investigate the correlation between excision repair cross-complementing 1 (ERCC1) expression and cisplatin sensitivity in non-small cell lung cancer (NSCLC).

Methods: A total of 168 NSCLC patients were selected from our hospital from January 2005 to December 2007. The expression of ERCC1 protein was analyzed by immunohistochemistry and ERCC1 mRNA tested by RT-PCR.

Outcome following surgery for squamous cell carcinoma of the oesophagus.

Introduction: This study was undertaken to determine the outcomes of patients treated for squamous cell carcinoma (SCC) of the oesophagus.

Methods: The study group consisted of 61 patients (median age: 64 years) with invasive SCC of the oesophagus who underwent resection between 1987 and 2007 in Adelaide, South Australia. Thirty-two (52%) were female.

[Preliminary investigation of the molecular mechanisms of imipenem-resistance in clinical isolates of Acinetobacter baumannii in Xi'an].

Objective: To investigate the molecular mechanism of carbapenem resistance in the clinical isolates of Acinetobacter baumannii from Xi'an and their profile of carbapenemase production.

Methods: A total of 146 Acinetobacter baumannii strains were isolated from 6 general hospitals in Xi'an. Antimicrobial susceptibility test was performed for all the strains, followed by detection of imipenem resistance using E-test for metallo-beta-lactamase (MBL) and NaCl inhibition test for OXA type carbapenemase.