IGF2BP1 promotes LPS-induced NFκB activation and pro-inflammatory cytokines production in human macrophages and monocytes.

Background: Lipopolysaccharide (LPS)-induced macrophage/monocyte activation and pro-inflammatory cytokines production are important mediators for periodontitis progression. The current study tested the potential role of insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in the process.

Methods: THP-1 human macrophages and primary human peripheral blood mononuclear cells (PBMCs) were treated with LPS.

Influence of Trabecular Bone on Peri-Implant Stress and Strain Based on Micro-CT Finite Element Modeling of Beagle Dog.

The objective of this investigation is to analyze the influence of trabecular microstructure modeling on the biomechanical distribution of the implant-bone interface. Two three-dimensional finite element mandible models, one with trabecular microstructure (a refined model) and one with macrostructure (a simplified model), were built. The values of equivalent stress at the implant-bone interface in the refined model increased compared with those of the simplified model and strain on the contrary.

Non-joint effusion is associated with osteoarthritis in temporomandibular joints with disk displacement.

Purpose: The aim of this study was to examine the possible association between different grades of joint effusion (JE) and osteoarthritis (OA) in temporomandibular joint (TMJ) anterior disk displacement without reduction (ADDwoR).

Material And Methods: A sample of 101 female patients 20-40 years of age with unilateral TMJ ADDwoR were retrospectively reviewed. JE and OA were diagnosed with magnetic resonance imaging (MRI).

Influence of orthotropy on biomechanics of peri-implant bone in complete mandible model with full dentition.

Objective: The study was to investigate the impact of orthotropic material on the biomechanics of dental implant, based on a detailed mandible with high geometric and mechanical similarity.

Materials And Methods: Multiple data sources were used to elaborate detailed biological structures and implant CAD models. In addition, an extended orthotropic material assignment methodology based on harmonic fields was used to handle the alveolar ridge region to generate compatible orthotropic fields.

Chronological changes in the microstructure of bone during peri-implant healing: a microcomputed tomographic evaluation.

Our objectives were to examine the titanium-bone interfaces chronologically and to clarify the process of osseointegration using microcomputed tomography (microCT). The mandibular premolars of 3 dogs were extracted and 12 weeks later 2 Straumann dental implants were installed in each quadrant. The microstructural changes at the bone-implant interface at the first, fourth, and eighth weeks after installation were evaluated by microCT and a 3-dimensional image was constructed.

Effect of sinus membrane perforation on the survival of implants placed in combination with osteotome sinus floor elevation.

This study was conducted to evaluate implant survival with regard to effects of sinus membrane perforation that occurred during osteotome sinus floor elevation (OSFE). The study group consisted of 42 patients with edentulous posterior maxilla. Implants placement combined with OSFE without a grafting material was performed.

Magnetic resonance imaging assessment of temporomandibular joint soft tissue injuries of intracapsular condylar fracture.

We evaluated the soft tissue of the temporomandibular joint (TMJ) with magnetic resonance imaging (MRI) after intracapsular condylar fracture. Eighteen consecutive patients (19 TMJ) were diagnosed between 1 January 2010 and 30 October 2011. They were examined using bilateral sagittal and coronal MRI, which were obtained immediately after injury to assess the displacement of the disc, whether there was a tear in capsule or the retrodiscal tissue, and whether there was an effusion in the joint.

[Clinical application of a self-developed bone collector in dental implantation].

Objective: To introduce a self-developed bone collector designed by the authors and evaluate its effect in clinical application.

Methods: A self-developed bone collector was used in 38 patients who underwent the dental implant operation from May 2008 to October 2009. During the operation the bone particles were harvested, which was used for the reconstruction of the bone defects around the implant simultaneously.

Real time 3D simulation for nose surgery and automatic individual prosthesis design.

This paper presents an intuitive nose surgery planning and simulation system, using 3D laser scan image and lateral X-ray image, to provide high quality prediction of the postoperative appearance, and design the patient specific prosthesis model automatically. After initial registration, the internal surface of soft tissue at the nose region was generated by the statistical data for soft tissue thickness adapted by the individual thickness information from the X-ray image. Then, the sketch contour of the 3D scan data on the lateral X-ray image was modified manually or adjusted automatically according to some aesthetic statistical data, to drive the simulation in real time by the state-of-the-art Laplacian surface deformation method.

[Infections of the head and neck leading to descending necrotizing mediastinitis: management of 9 cases].

Objective: To report nine cases of descending necrotizing mediastinitis (DNM) and to summarize the management experience.

Methods: Between December 2005 and December 2008, nine patients (mean age, 55.7 years; age range, 38 to 78 years) with DNM were treated.

[Three dimension finite element analysis of anisotropic mandible with dental implants effect on implant-bone interface].

Objective: To establish anisotropic mandible model with dental implants and to investigate the effect of anisotropy material on stress and strain distribution of implant-bone interface.

Methods: Three-dimensional finite element models of whole mandible with anisotropic and equivalent isotropic material were created by CT scanning and universal surgical integration system (USIS) software developed by the authors. Two ITI threaded implants were implanted in the posterior teeth area.

Implant-bone interface stress distribution in immediately loaded implants of different diameters: a three-dimensional finite element analysis.

Purpose: To establish a 3D finite element model of a mandible with dental implants for immediate loading and to analyze stress distribution in bone around implants of different diameters.

Materials And Methods: Three mandible models, embedded with thread implants (ITI, Straumann, Switzerland) with diameters of 3.3, 4.

Effect of diameter and length on stress distribution of the alveolar crest around immediate loading implants.

Background: Many clinical observations have shown that immediate loading is indicated when the stabilization of the bone/implant is optimal and when the estimated loads are not excessively high. Nonetheless, more experimental studies are needed to consider the immediate loading protocol as a safe procedure. Mechanical analysis using the finite element (FE) method analysis has been employed by many authors to understand the biomechanical behavior around dental implants.

[Experimental study on the reconstruction of mandibular symphyseal defects by internal tri-focal distractor].

Objective: To introduce the internal tri-focal distractor developed by the authors and evaluate its primary application and feasibility in animal experiment.

Methods: Four hybrid dogs were selected and segmental resection at the mandibular symphysis was performed. Two transfer disks, 10 mm in width, were respectively fixed at the two ends of bone defect and the internal tri-focal distractor was installed.

[Establishment of a three-dimensional finite element model of mandible with dental implants for immediate loading].

Purpose: To establish a three-dimensional finite element model of mandible with dental implants for immediate loading, which will provide a basis for study of the biomechanical characteristics of the immediate loading implant-bone interface.

Methods: A female edentulous mandible was adopted for CT scanning, the scanned data were saved with the form of DICOM, and then input into compute. Universal Surgical Integration System which was developed by ourselves and ANSYS 10.

[A finite element analysis system for two-demension morphological analysis of the soft tissue in orthognathic surgery].

Objective: To evaluate a finite element method (FEM) for analysis of the cranial-facial morphology.

Methods: The two-dimensional finite element analysis system was established and used to analysis the lateral side morphology of the soft tissue by the change of each finite unit of the soft tissue in a X-ray cranial-facial lateral cepholometrics film.

Results: The finite element analysis system was showing very well in the figures and data made by the system.