Comparative study among three different methods of bone marrow mesenchymal stem cell transplantation following cerebral infarction in rats.

The objective of this study was to investigate the effects of transplanted bone marrow mesenchymal stem cells (BMSCs) administered via internal jugular vein injection, carotid artery injection, or intraventricular transplantation for the treatment of cerebral infarction, which was modeled in rats. The neurological scores of the treated rats and the distribution of the transplanted cells (GFP-labeled) in the infarction area were evaluated. The cerebral infarction model was produced by inserting a modified Zea-longa suture, which generated middle cerebral artery occlusion (MCAO).

[Evaluation of neurological function following establishment of spinal cord hemisection model in rhesus].

Objective: To establish spinal cord half-transection model in rhesus and investigate the Four neurological function and morphologic changes following spinal cord hemisection in rhesus.

Methods: Four cynomolgus monkeys were subjected to T-11 laminectomy and resection of a 1-mm length of hemispinal cord, while the controls underwent the identical laminectomy procedure but not the half-transection of the spinal cord. Neurological function of hindlimb was evaluated using modified Tarlov' grading, and cortical somatosensary evoked potentials (CSEP) were recorded in the 3rd postoperative month after spinal cord injury (SCI).