[Protective effect of early intervention with lipoxin A4 on septic mice].

Objective: To study the effect of early intervention with lipoxin A4 (LXA4) on septic mice.

Methods: Healthy male Balb/c mice aged 6-8 weeks were randomly divided into sham-operation group, sepsis group, 1-hour intervention group (intervention at 1 hour after sepsis), and 6-hour intervention group (intervention at 6 hours after sepsis) (n=8 each). A sepsis model was prepared by cecal ligation and puncture.