The Spatiotemporal Pattern and Its Determinants of Hemorrhagic Fever With Renal Syndrome in Northeastern China: Spatiotemporal Analysis.

Background: Hemorrhagic fever with renal syndrome (HFRS) is a significant zoonotic disease mainly transmitted by rodents. However, the determinants of its spatiotemporal patterns in Northeast China remain unclear.

Objective: This study aimed to investigate the spatiotemporal dynamics and epidemiological characteristics of HFRS and detect the meteorological effect of the HFRS epidemic in Northeastern China.

Association between the NEP rs701109 polymorphism and the clinical efficacy and safety of sacubitril/valsartan in Chinese patients with heart failure.

Objective: Sacubitril/valsartan is a commonly used medicine for treating heart failure (HF) patients, but the treatment effects significantly vary. Neprilysin (NEP) and carboxylesterase 1 (CES1) play an important role in the efficacy of sacubitril/valsartan. The purpose of this study was to explore the relationship between NEP and CES1 gene polymorphisms and the efficacy and safety of sacubitril/valsartan treatment in HF patients.

[Expression of cancerous inhibitor of protein phosphatase 2A in tissue microarray of colorectal cancer and its clinical significance].

Objective: To investigate the expression of cancerous inhibitor of protein phosphatase 2A(CIP2A) in human colorectal cancer, and to examine the association of CIP2A expression with clinicopathology and prognosis.

Methods: CIP2A expression in colorectal cancer tissue microarray of 92 cases was detected by immunohistochemistry method.

Results: Up-regulated CIP2A expression was closely related with TNM staging, histological type, peritoneal seeding and liver metastasis (all P<0.

[Effect of the liposome albendazole and Huai-Er fungus extract on hepatic infection of Echinococcus granulosus in mice].

Objective: To explore the effect of Huai-Er fungus extract (HEF) and liposome albendazole (L-ABZ) on the hepatic infection of Echinococcus granulosus (Eg) in mice, and understand the influence of improved host immunity on postoperative recurrence.

Methods: Female Kunming mice were immune by intraperitoneal injection Eg cyst fluid from sheep, IgG positive mice were divided into drug treatment groups (A, B and C) and control group (D). Mice in group A were administered by gavage with single L-ABZ (75 mg/kg), group B with single HEF (15,000 mg/kg), and group C with combination therapy (L-ABZ 75 mg/kg plus HEF 15,000 mg/kg), once every two days for one week.