Multiple spinal gas in an 86-year-old diabetic man.

Although spinal gas is common and can be found in various sites and lesions, it should prompt a search for the underlying cause, given that the clinical significance of ectopic gas varies from benign to scary. Spinal gas can occur in the traumatic, iatrogenic, degenerative, osteoporotic, infectious, or neoplastic lesions. The imaging similarity may cause the misdiagnosis or delayed diagnosis which sometimes requires immediate attention.

Homozygous Mutation of Causes Infertility in Female Nile Tilapia ().

Gonadal somatic cell-derived factor (Gsdf) is a member of the TGF-β superfamily, which exists mainly in fishes. Homozygous mutations in Japanese medaka and zebrafish resulted in infertile females, and the reasons for their infertility remain unknown. This study presents functional studies of Gsdf in ovary development using CRISPR/Cas9 in Nile tilapia ().

Genome-wide identification, evolution of DNA methyltransferases and their expression during gonadal development in Nile tilapia.

DNA methyltransferases (dnmts) are responsible for DNA methylation and play important roles in organism development. In this study, seven dnmts genes (dnmt1, dnmt2, dnmt3aa, dnmt3ab, dnmt3ba, dnmt3bb.1, dnmt3bb.

Discovery of FIXa inhibitors by combination of pharmacophore modeling, molecular docking, and 3D-QSAR modeling.

Human Coagulation Factor IXa (FIXa), specifically inhibited at the initiation stage of the blood coagulation cascade, is an excellent target for developing selective and safe anticoagulants. To explore this inhibitory mechanism, 86 FIXa inhibitors were selected to generate pharmacophore models and subsequently SAR models. Both best pharmacophore model and ROC curve were built through the Receptor-Ligand Pharmacophore Generation module.