Publications by authors named "Xing-Ya Qin"
Article Synopsis
- Hesperetin (HES) shows potential protective effects against renal fibrosis, providing a new area for research as its effects had only been previously documented for cardiac and lung fibrosis.
- HES was tested in both a mouse model and kidney cell model, leading to significant reductions in kidney injury and extracellular matrix components linked to fibrosis.
- The treatment also suppressed epithelial-to-mesenchymal transition (EMT) and inhibited the hedgehog signaling pathway, suggesting these mechanisms are key to HES's anti-fibrotic action.
This study investigated whether oxymatrine (OMT) treatment can ameliorate renal interstitial fibrosis in unilateral ureteral obstruction (UUO) mice model. Moreover, the potential mechanisms of such treatment were analyzed. Twenty-four C57/BL6 mice were randomly divided into three groups, namely sham group, vehicle plus unilateral ureteral obstruction (UUO)-treated group, and 100 mg/kg/d OMT plus UUO-treated group.
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