Publications by authors named "Xing-Wen Feng"
A two-step sequential biocatalytic process for the synthesis of chiral hydroxyesters that combines a lipase-catalyzed decarboxylative aldol reaction followed by kinetic resolution has been developed. The excellent combination of conventional and unconventional functions provides an attractive route for expanding the applications of biocatalysis.
View Article and Find Full Text PDFArticle Synopsis
- The report details the synthesis and testing of 11-aminoalkylamino-substituted 5H- and 6H-indolo[2,3-b]quinoline derivatives for their ability to inhibit cell growth.
- The 5-methyl derivatives were found to be more cytotoxic in vitro compared to the 6-methyl variants, with a specific compound showing a very low IC(50) value against human leukemia cells.
- Additionally, the binding affinity of these compounds to DNA was assessed, suggesting they intercalate into DNA with significant binding constants.
Article Synopsis
- Several proteases, particularly pepsin, have been found to effectively catalyze asymmetric aldol reactions, demonstrating their versatility beyond traditional roles.
- Pepsin showed good efficiency in a specific reaction involving acetone and 4-nitrobenzaldehyde, yielding high amounts of product with decent enantioselectivity while maintaining its structure under neutral pH conditions.
- The stability of pepsin over multiple reaction cycles suggests its potential in sustainable organic synthesis methods, broadening the scope of protease applications in chemistry.
Article Synopsis
- A new method for making sulfones has been developed, using sulfonyl hydrazones, which are derived from carbonyl compounds.
- The synthesis occurs through a process involving the loss of nitrogen, facilitated by a simple copper salt and a base.
- This technique successfully produces a range of aryl and alkyl sulfones with moderate to good yield results.
Ketoprofen-saccharide conjugates were synthesized by selectively enzymatic hydrolysis and acylation. Firstly, the (S)-ketoprofen vinyl ester was prepared by enzymatic hydrolysis of (R,S)-ketoprofen vinyl ester. Then enzymatic transesterification of (S)-ketoprofen vinyl ester with a series of saccharides were performed by the catalysis of a commercial protease from Bacillus licheniformis (BLP) in organic medium mixture of pyridine and tert-butanol.
View Article and Find Full Text PDF