Angelicin: A leading culprit involved in fructus Psoraleae liver injury via inhibition of VKORC1.

Ethnopharmacological Relevance: The adverse effects of Fructus Psoraleae (FP), especially liver injury, have attracted wide attention in recent years.

Aim Of The Study: To establish a system to explore potential hepatotoxic targets and the chief culprit of liver injury based on clinical experience, network pharmacological method, molecular docking, and in vitro and in vivo experiments.

Materials And Methods: Clinical applications and adverse reactions to FP were obtained from public literatures.

[Comparative study of purgative pharmacological effects and mechanisms of Moringa oleifera leaves and Rhei Radix et Rhizoma].

Moringa oleifera leaves are known for their "Virechana"(purgative) effect in Ayurvedic medicine in India. This study compared the purgative effects and mechanisms of M. oleifera leaves with the reference Rhei Radix et Rhizoma to establish a foundation for the further application of M.