Publications by authors named "Xing-Mei Long"
Liver fibrosis is the initial pathological process of many chronic liver diseases. Targeting hepatic stellate cell (HSC) activation is an available strategy for the therapy of liver fibrosis. We aimed to explore the anti-liver fibrosis activity and potential mechanism of phomopsterone B (PB) in human HSCs.
View Article and Find Full Text PDFThree new compounds including a meroterpenoid () and two isocoumarins ( and ), together with thirteen known compounds (, ) were isolated from the metabolites of MST1-15. Their structures were identified by a combination of spectroscopic analysis. The absolute configuration of compound was elucidated on the basis of experimental and electronic circular dichroism calculation, and compounds and were determined by Mo(OAc)-induced circular dichroism experiments.
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- - A new derivative of helvolic acid and nine known compounds were isolated from the MST1-10 metabolites using a method called bioassay-guided fractionation.
- - The structures of these compounds were identified through spectroscopic analysis, with the absolute configuration of the new compound determined using NOESY and ECD spectra.
- - The new compound demonstrated strong antibacterial activity with a minimum inhibitory concentration (MIC) of 2 μg/mL, significantly outperforming Trimethoprim (MIC = 64 μg/mL), and showed high biofilm inhibition rates at varying concentrations.
Two fusidane-type active compounds ( and ) and five new ones (), along with other nine known compounds () were isolated from the metabolites of MST7-3. Their structures were elucidated on the basis of spectroscopic analysis. The absolute configurations of compounds and were established by Mosher's method and optical rotation.
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